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  • Stereoselective synthesis of a novel chiral piperazine.
    [作者:Kojima, Satoshi;Chabayashi, Takashi;Umeda, Yasuhiro;Iwamoto, Akihisa;Tanabe, Kazuhisa;Ohkata, Katsuo;,期刊:Heterocycles, 页码:1493-1501 , 文章类型: 研究论文,,卷期:2008年75-6]
  • (2S,6S)-2,4,6-Tris(phenylmethyl)piperazine was prepd. in 11 steps and 53% overall yield from S-phenylalanine. Key steps in the synthesis involved reductive amination to introduce an ethoxycarbonylmethyl group on to the ...