- Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells
[作者:Saretzki, G; Walter, T; Atkinson, S; Passos, JF; Bareth, B; Keith, WN; Stewart, R; Hoare, S; Stojkovic, M; Armstrong, L; von Zglinicki, T; Lako, M,期刊:Stem Cells, 页码:455-464 , 文章类型: Article,,卷期:2008年26-2]
- Evolutionary theory predicts that cellular maintenance, stress defense, and DNA repair mechanisms should be most active in germ line cells, including embryonic stem cells that can differentiate into germ line cells, wher...
- Derivation, characterization, and in vitro differentiation of canine embryonic stem cells
[作者:Hayes, B; Fagerlie, SR; Ramakrishnan, A; Baran, S; Harkey, M; Graf, L; Bar, M; Bendoraite, A; Tewari, M; Torok-Storb, B,期刊:Stem Cells, 页码:465-473 , 文章类型: Article,,卷期:2008年26-2]
- Canine embryonic stem (cES) cell lines were generated to establish a large-animal preclinical model for testing the safety and efficacy of embryonic stem (ES) cell-derived tissue replacement therapy. Putative cES cell li...
- Fluorophore-conjugated iron oxide nanoparticle labeling and analysis of engrafting human hematopoietic stein cells
[作者:Maxwell, DJ; Bonde, J; Hess, DA; Hohm, SA; Lahey, R; Zhou, P; Creer, MH; Piwnica-Worms, D; Nolta, JA,期刊:Stem Cells, 页码:517-524 , 文章类型: Article,,卷期:2008年26-2]
- The use of nanometer-sized iron oxide particles combined with molecular imaging techniques enables dynamic studies of homing and trafficking of human hematopoietic stem cells (HSC). Identifying clinically applicable stra...
- In vitro- and in vivo-induced transgene expression in human embryonic stem cells and derivatives
[作者:Xia, X; Ayala, M; Thiede, BR; Zhang, SC,期刊:Stem Cells, 页码:525-533 , 文章类型: Article,,卷期:2008年26-2]
- The use of human embryonic stem cells (hESCs) as a research and therapeutic tool will be facilitated by conditional gene expression. Here, we report drug-induced transgene expression, both in vitro and in vivo, from a te...
- Activin afters the kinetics of endoderm induction in embryonic stem cells cultured on collagen gels
[作者:Parashurama, N; Nahmias, Y; Cho, CH; van Poll, D; Tilles, AW; Berthiaume, F; Yarmush, ML,期刊:Stem Cells, 页码:474-484 , 文章类型: Article,,卷期:2008年26-2]
- Embryonic stem cell-derived endoderm is critical for the development of cellular therapies for the treatment of disease such as diabetes, liver cirrhosis, or pulmonary emphysema. Here, we describe a novel approach to ind...
- Adenoviral vector-mediated transfer of the Indian hedgehog gene modulates lymphomyelopoiesis in vivo
[作者:Kobune, M; Kato, J; Kawano, Y; Sasaki, K; Uchida, H; Takada, K; Takahashi, S; Takimoto, R; Niitsu, Y,期刊:Stem Cells, 页码:534-542 , 文章类型: Article,,卷期:2008年26-2]
- Indian hedgehog (Ihh) plays an essential role in angiogenesis, hematogenesis, and epiphysis formation during embryogenesis. In the present study, we injected an adenoviral vector (Adv) carrying the mock-control (Adv-cont...
- Ex vivo culture of human cord blood hematopoietic stem/progenitor cells adversely influences their distribution to other bone marrow compartments after intra-bone marrow transplantation
[作者:Yamamura, K; Ohishi, K; Masuya, M; Miyata, E; Sugimoto, Y; Nakamura, S; Fujieda, A; Araki, H; Katayama, N,期刊:Stem Cells, 页码:543-549 , 文章类型: Article,,卷期:2008年26-2]
- Intra-bone marrow injection is a novel strategy for hematopoietic stem cell transplantation. Here, we investigated whether ex vivo culture of cord blood hematopoietic stem/progenitor cells influences their reconstitution...
- Development of human cloned blastocysts following somatic cell nuclear transfer with adult fibroblasts
[作者:French, AJ; Adams, CA; Anderson, LS; Kitchen, JR; Hughes, MR; Wood, SH,期刊:Stem Cells, 页码:485-493 , 文章类型: Article,,卷期:2008年26-2]
- Nuclear transfer stem cells hold considerable promise in the field of regenerative medicine and cell-based drug discovery. In this study, a total of 29 oocytes were obtained from three young (20 - 24 years old) reproduct...
- Trafficking of multipotent mesenchymal stromal cells from maternal circulation through the placenta involves vascular endothelial growth factor receptor-1 and integrins
[作者:Chen, CP; Lee, MY; Huang, JP; Aplin, JD; Wu, YH; Hu, CS; Chen, PC; Li, H; Hwang, SM; Liu, SH; Yang, YC,期刊:Stem Cells, 页码:550-561 , 文章类型: Article,,卷期:2008年26-2]
- Maternal cells can become engrafted in various fetal organs during pregnancy. The nature of the cells and the mechanisms of maternofetal cell trafficking are not clear. We demonstrate that human lineage-negative, CD34-ne...
- Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus erythematosus patients
[作者:Traggiai, E; Volpi, S; Schena, F; Gattorno, M; Ferlito, F; Moretta, L; Martini, A,期刊:Stem Cells, 页码:562-569 , 文章类型: Article,,卷期:2008年26-2]
- Human bone marrow multipotent mesenchymal stromal cells are progenitor cells that can be expanded in vitro and differentiate into various cells of mesodermal origin. They contribute to the bone marrow reticular niche, wh...
- Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration
[作者:Smith, JR; Maguire, S; Davis, LA; Alexander, M; Yang, FT; Chandran, S; Ffrench-Constant, C; Pedersen, RA,期刊:Stem Cells, 页码:496-504 , 文章类型: Article,,卷期:2008年26-2]
- Silencing and variegated transgene expression are poorly understood problems that can interfere with gene function studies in human embryonic stem cells (hESCs). We show that transgene expression (enhanced green fluoresc...
- Adipose-derived stem cells are a source for cell therapy of the corneal stroma
[作者:Arnalich-Montiel, F; Pastor, S; Blazquez-Martinez, A; Fernandez-Delgado, J; Nistal, M; Alio, JL; De Miguel, MP,期刊:Stem Cells, 页码:570-579 , 文章类型: Article,,卷期:2008年26-2]
- Most corneal diseases affect corneal stroma and include immune or infectious diseases, ecstatic disorders, traumatic scars, and corneal dystrophies. Cell-based therapy is a promising therapeutic approach to overcome the ...
- Efficient in vitro labeling of human neural precursor cells with superparamagnetic iron oxide particles: Relevance for in vivo cell tracking
[作者:Neri, M; Maderna, C; Cavazzin, C; Deidda-Vigoriti, V; Politi, LS; Scotti, G; Marzola, P; Sbarbati, A; Vescovi, AL; Gritti, A,期刊:Stem Cells, 页码:505-516 , 文章类型: Article,,卷期:2008年26-2]
- Recent studies have raised appealing possibilities of replacing damaged or lost neural cells by transplanting in vitro-expanded neural precursor cells (NPCs) and/or their progeny. Magnetic resonance (MR) tracking of supe...
- Morphological and functional characterization of predifferentiation of myelinating glia-like cells from human bone marrow stromal cells through activation of F3/Notch signaling in mouse retina
[作者:Lu, L; Chen, X; Zhang, CW; Yang, WL; Wu, YJ; Sun, L; Bai, LM; Gu, XS; Ahmed, S; Dawe, GS; Xiao, ZC,期刊:Stem Cells, 页码:580-590 , 文章类型: Article,,卷期:2008年26-2]
- Recently, we have demonstrated that F3/contactin and NB-3 are trans-acting extracellular ligands of Notch that promote differentiation of neural stem cells and oligodendrocyte precursor cells into mature oligodendrocytes...
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