- A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion
[作者:Guay, C; Madiraju, SRM; Aumais, A; Joly, E; Prentki, M,期刊:Journal of Biological Chemistry, 页码:35657-35665 , 文章类型: Article,,卷期:2007年282-49]
- In pancreatic beta-cells, metabolic coupling factors generated during glucose metabolism and pyruvate cycling through anaplerosis/cataplerosis processes contribute to the regulation of insulin secretion. Pyruvate/citrate...
- Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants
[作者:Cohen, O; Kronman, C; Lazar, A; Velan, B; Shafferman, A,期刊:Journal of Biological Chemistry, 页码:35491-35501 , 文章类型: Article,,卷期:2007年282-49]
- Cholinesterases are efficient scavengers of organophosphates and are currently being developed as drugs for treatment against poisoning by such compounds. Recombinant ChE bioscavengers have very short circular longevity,...
- Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of rac family small GTPases
[作者:Shutes, A; Onesto, C; Picard, V; Leblond, B; Schweighoffer, F; Der, CJ,期刊:Journal of Biological Chemistry, 页码:35666-35678 , 文章类型: Article,,卷期:2007年282-49]
- There is now considerable experimental evidence that aberrant activation of Rho family small GTPases promotes the uncontrolled proliferation, invasion, and metastatic properties of human cancer cells. Therefore, there is...
- Truncation of annexin A1 is a regulatory lever for linking epidermal growth factor signaling with cytosolic phospholipase A2 in normal and malignant squamous epithelial cells
[作者:Sakaguchi, M; Murata, H; Sonegawa, H; Sakaguchi, Y; Futami, J; Kitazoe, M; Yamada, H; Huh, N,期刊:Journal of Biological Chemistry, 页码:35679-35686 , 文章类型: Article,,卷期:2007年282-49]
- Regulation of cell growth and apoptosis is one of the pleiotropic functions of annexin A1 (ANXA1). Although previous reports on the overexpression of ANXA1 in many human cancers and on growth suppression and/or induction...
- Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1
[作者:Carlson, EC; Lin, M; Liu, CY; Kao, WWY; Perez, VL; Pearlman, E,期刊:Journal of Biological Chemistry, 页码:35502-35509 , 文章类型: Article,,卷期:2007年282-49]
- Keratocan and lumican are keratan-sulfate proteoglycans (KSPG), which have a critical role in maintaining corneal clarity. To determine whether these KSPGs have a role in corneal inflammation, we examined Kera(-/-) and L...
- Shear-induced disulfide bond formation regulates adhesion activity of von Willebrand factor
[作者:Choi, H; Aboulfatova, K; Pownall, HJ; Cook, R; Dong, JF,期刊:Journal of Biological Chemistry, 页码:35604-35611 , 文章类型: Article,,卷期:2007年282-49]
- von Willebrand factor (VWF) is the largest multimeric adhesion ligand circulating in blood. Its adhesion activity is related to multimer size, with the ultra-large forms freshly released from the activated endothelial ce...
- The ATPase cycle of the endoplasmic chaperone Grp94
[作者:Frey, S; Leskovar, A; Reinstein, J; Buchner, J,期刊:Journal of Biological Chemistry, 页码:35612-35620 , 文章类型: Article,,卷期:2007年282-49]
- Grp94, the Hsp90 paralog of the endoplasmic reticulum, plays a crucial role in protein secretion. Like cytoplasmic Hsp90, Grp94 is regulated by nucleotide binding to its N-terminal domain. However, the question of whethe...
- Critical and functional regulation of CHOP (c/EBP homologous protein) through the N-terminal portion
[作者:Ohoka, N; Hattori, T; Kitagawa, M; Onozaki, K; Hayashi, H,期刊:Journal of Biological Chemistry, 页码:35687-35694 , 文章类型: Article,,卷期:2007年282-49]
- C/EBP homologous protein (CHOP) is an endoplasmic reticulum stress-inducible protein that plays a critical role in the regulation of programmed cell death; however, the regulation of its function has not been well charac...
- Spectroscopic and kinetic studies of Y114F and W116F mutants of Me2SO reductase from Rhodobacter capsulatus
[作者:Cobb, N; Hemann, C; Polsinelli, GA; Ridge, JP; McEwan, AG; Hille, R,期刊:Journal of Biological Chemistry, 页码:35519-35529 , 文章类型: Article,,卷期:2007年282-49]
- Mutants of the active site residues Trp-116 and Tyr-114 of the molybdenum-containing Me2SO reductase from Rhodobacter capsulatus have been examined spectroscopically and kinetically. The Y114F mutant has an increased rat...
- Crystal structure of Cel44A, a glycoside hydrolase family 44 endoglucanase from Clostridium thermocellum
[作者:Kitago, Y; Karita, S; Watanabe, N; Kamiya, M; Aizawa, T; Sakka, K; Tanaka, I,期刊:Journal of Biological Chemistry, 页码:35703-35711 , 文章类型: Article,,卷期:2007年282-49]
- The crystal structure of Cel44A, which is one of the enzymatic components of the cellulosome of Clostridium thermocellum, was solved at a resolution of 0.96 angstrom. This enzyme belongs to glycoside hydrolase family (GH...
- The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events
[作者:Moss, ML; Bomar, M; Liu, Q; Sage, H; Dempsey, P; Lenhart, PM; Gillispie, PA; Stoeck, A; Wildeboer, D; Bartsch, JW; Palmisano, R; Zhou, P,期刊:Journal of Biological Chemistry, 页码:35712-35721 , 文章类型: Article,,卷期:2007年282-49]
- ADAM10 is a disintegrin metalloproteinase that processes amyloid precursor protein and ErbB ligands and is involved in the shedding of many type I and type II single membrane-spanning proteins. Like tumor necrosis factor...
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