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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共56条记录   The cytoplasmic domain of the hyaluronan receptor for endocytosis (HARE) contains multiple endocytic motifs targeting coated pit-mediated internalization [作者：Pandey, MS; Harris, EN; Weigel, JA; Weigel, PH,期刊：Journal of Biological Chemistry, 页码：21453-21461 , 文章类型： Article，,卷期：2008年283-31] The hyaluronic acid (HA) receptor for endocytosis (HARE) is the primary scavenger receptor for HA and chondroitin sulfates in mammals. The two human isoforms of HARE (full-length 315-kDa and a 190-kDa proteolytic cleavag... The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells [作者：Gao, J; Zhao, N; Knutson, MD; Enns, CA,期刊：Journal of Biological Chemistry, 页码：21462-21468 , 文章类型： Article，,卷期：2008年283-31] Lack of functional hereditary hemochromatosis protein, HFE, causes iron overload predominantly in hepatocytes, the major site of HFE expression in the liver. In this study, we investigated the role of HFE in the regulati... The PHD domain of plant PIAS proteins mediates sumoylation of bromodomain GTE proteins [作者：Garcia-Dominguez, M; March-Diaz, R; Reyes, JC,期刊：Journal of Biological Chemistry, 页码：21469-21477 , 文章类型： Article，,卷期：2008年283-31] Covalent attachment of small ubiquitin-like modifier ( SUMO) to proteins regulates multiple processes in the eukaryotic cell. In numerous cases sumoylation is facilitated by protein inhibitor of activated STAT(PIAS) prot... Modulation of nicotinic acetylcholine receptor conformational state by free fatty acids and steroids [作者：Nievas, GAF; Barrantes, FJ; Antollini, SS,期刊：Journal of Biological Chemistry, 页码：21478-21486 , 文章类型： Article，,卷期：2008年283-31] Steroids and free fatty acids (FFA) are noncompetitive antagonists of the nicotinic acetylcholine receptor (AChR). Their site of action is purportedly located at the lipid-AChR interface, but their exact mechanism of act... The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways [作者：Dodeller, F; Gottar, M; Huesken, D; Iourgenko, V; Cenni, B,期刊：Journal of Biological Chemistry, 页码：21487-21494 , 文章类型： Article，,卷期：2008年283-31] The intracellular signaling pathway by which tumor necrosis factor (TNF) induces its pleiotropic actions is well characterized and includes unique components as well as modules shared with other signaling pathways. In ad... Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125 [作者：Chu, MLH; Chavas, LMG; Douglas, KT; Eyers, PA; Tabernero, L,期刊：Journal of Biological Chemistry, 页码：21495-21500 , 文章类型： Article，,卷期：2008年283-31] Chromosomal instability can result from defective control of checkpoints and is associated with malignant cell growth. Monopolar spindle 1 (Mps1) is a dual-specificity protein kinase that has important roles in the preve... The molecular cloning of artemisinic aldehyde Delta 11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua [作者：Zhang, Y; Teoh, KH; Reed, DW; Maes, L; Goossens, A; Olson, DJH; Ross, ARS; Covello, PS,期刊：Journal of Biological Chemistry, 页码：21501-21508 , 文章类型： Article，,卷期：2008年283-31] At some point during biosynthesis of the antimalarial artemisinin in glandular trichomes of Artemisia annua, the Delta 11(13) double bond originating in amorpha-4,11-diene is reduced. This is thought to occur in artemisi... The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability [作者：Rajabi, M; de Leeuw, E; Pazgier, M; Li, J; Lubkowski, J; Lu, W,期刊：Journal of Biological Chemistry, 页码：21509-21518 , 文章类型： Article，,卷期：2008年283-31] Mammalian alpha-defensins, expressed primarily in leukocytes and epithelia, play important roles in innate and adaptive immune responses to microbial infection. Six invariant cysteine residues forming three indispensable... Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds [作者：Blanke, ML; VanDongen, AMJ,期刊：Journal of Biological Chemistry, 页码：21519-21529 , 文章类型： Article，,卷期：2008年283-31] Although the N-methyl-D-aspartate (NMDA) receptor plays a critical role in the central nervous system, many questions remain regarding the relationship between its structure and functional properties. In particular, the ... The molecular basis of functional bacterial amyloid polymerization and nucleation [作者：Wang, X; Hammer, ND; Chapman, MR,期刊：Journal of Biological Chemistry, 页码：21530-21539 , 文章类型： Article，,卷期：2008年283-31] Amyloid fibers are filamentous proteinaceous structures commonly associated with mammalian neurodegenerative diseases. Nucleation is the rate-limiting step of amyloid propagation, and its nature remains poorly understood... Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death [作者：Wan, GH; Zhaorigetu, S; Liu, ZH; Kaini, R; Jiang, ZY; Hu, CAA,期刊：Journal of Biological Chemistry, 页码：21540-21549 , 文章类型： Article，,卷期：2008年283-31] The Bcl-2 family proteins are important regulators of type I programmed cell death apoptosis; however, their role in autophagic cell death (AuCD) or type II programmed cell death is still largely unknown. Here we report ... Structural determinants underlying the temperature-sensitive nature of a G alpha mutant in asymmetric cell division of Caenorhabditis elegans [作者：Johnston, CA; Afshar, K; Snyder, JT; Tall, GG; Gonczy, P; Siderovski, DP; Willard, FS,期刊：Journal of Biological Chemistry, 页码：21550-21558 , 文章类型： Article，,卷期：2008年283-31] Heterotrimeric G-proteins are integral to a conserved regulatory module that influences metazoan asymmetric cell division (ACD). In the Caenorhabditis elegans zygote, GOA-1 (G alpha(o)) and GPA-16 (G alpha(i)) are involv... Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA) [作者：Binz, SK; Wold, MS,期刊：Journal of Biological Chemistry, 页码：21559-21570 , 文章类型： Article，,卷期：2008年283-31] Replication protein A (RPA) is the major single-stranded DNA-binding protein in eukaryotes. RPA is composed of three subunits of 70, 32, and 14 kDa. The N-terminal domain of the 70-kDa subunit (RPA70) has weak DNA bindin... In vivo targets of S-thiolation in Chlamydomonas reinhardtii [作者：Michelet, L; Zaffagnini, M; Vanacker, H; Le Marechal, P; Marchand, C; Schroda, M; Lemaire, SD; Decottignies, P,期刊：Journal of Biological Chemistry, 页码：21571-21578 , 文章类型： Article，,卷期：2008年283-31] Glutathionylation is the major form of S-thiolation in cells. This reversible redox post-translational modification consists of the formation of a mixed disulfide between a free thiol on a protein and a molecule of gluta... ATP modulation of Ca2+ release by type-2 and type-3 inositol (1,4,5)-triphosphate receptors - Differing ATP sensitivities and molecular determinants of action [作者：Betzenhauser, MJ; Wagner, LE; Iwai, M; Michikawa, T; Mikoshiba, K; Yule, DI,期刊：Journal of Biological Chemistry, 页码：21579-21587 , 文章类型： Article，,卷期：2008年283-31] ATP enhances Ca2+ release from inositol (1,4,5)-trisphosphate receptors (InsP(3)R). However, the three isoforms of InsP(3)R are reported to respond to ATP with differing sensitivities. Ca2+ release through InsP(3)R(1) is... RhoA-GDP regulates RhoB protein stability - Potential involvement of RhoGDI alpha [作者：Ho, TTG; Merajver, SD; Lapiere, CM; Nusgens, BV; Deroanne, CF,期刊：Journal of Biological Chemistry, 页码：21588-21598 , 文章类型： Article，,卷期：2008年283-31] RhoA plays a significant role in actin stress fibers formation. However, silencing RhoA alone or RhoA and RhoC did not completely suppress the stress fibers suggesting a residual "Rho-like" activity. RhoB, the third memb...