- Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic degeneration
[作者：Venneti, S; Bonneh-Barkay, D; Lopresti, BJ; Bissel, SJ; Wang, G; Mathis, CA; Piatak, M; Lifson, JD; Nyaundi, JO; Murphey-Corb, M; Wiley, CA,期刊：American Journal of Pathology, 页码：1603-1616 , 文章类型： Article，,卷期：2008年172-6]
- Human immunodeficiency virus encephalitis is characterized by infiltration of the brain with infected and activated macrophages; however, it is not known why disease occurs after variable lengths of infection in 25% of i...
- Methamphetamine enhances HIV infection of macrophages
[作者：Liang, H; Wang, X; Chen, H; Song, L; Ye, L; Wang, SH; Wang, YJ; Zhou, L; Ho, WZ,期刊：American Journal of Pathology, 页码：1617-1624 , 文章类型： Article，,卷期：2008年172-6]
- Epidemiological studies have demonstrated that the use of methamphetamine (meth), a sympathomimetic stimulant, is particularly common among patients infected with HIV. However, there is a lack of direct evidence that met...
- Multiple pathogenic roles of microvasculature in inflammatory bowel disease: A jack of all trades
[作者：Deban, L; Correale, C; Vetrano, S; Malesci, A; Danese, S,期刊：American Journal of Pathology, 页码：1457-1466 , 文章类型： Review，,卷期：2008年172-6]
- The etiology of Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), is still largely unknown. However, it is now clear that the abnormalities underlying pathogenesis of intest...
- Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice
[作者：Nagata, N; Iwata, N; Hasegawa, H; Fukushi, S; Harashima, A; Sato, Y; Saijo, M; Taguchi, F; Morikawa, S; Sata, T,期刊：American Journal of Pathology, 页码：1625-1637 , 文章类型： Article，,卷期：2008年172-6]
- Advanced age is a risk factor of severe acute respiratory syndrome (SARS) in humans. To understand its pathogenesis, we developed an animal model using BALB/c mice and the mouse-passaged Frankfurt 1 isolate of SARS coron...
- Mast cells regulate the magnitude and the cytokine microenvironment of the contact hypersensitivity response
[作者：Norman, MU; Hwang, J; Hulliger, S; Bonder, CS; Yamanouchi, J; Santamaria, P; Kubes, P,期刊：American Journal of Pathology, 页码：1638-1649 , 文章类型： Article，,卷期：2008年172-6]
- The role that mast cells play during contact hypersensitivity (CS) response is unclear because some studies have shown that mast cell-deficient mice have relatively intact CS responses whereas others have shown opposing ...
- CD19 regulates skin and lung fibrosis via toll-like receptor signaling in a model of bleomycin-induced scleroderma
[作者：Yoshizaki, A; Iwata, Y; Komura, K; Ogawa, F; Hara, T; Muroi, E; Takenaka, M; Shimizu, K; Hasegawa, M; Fujimoto, M; Tedder, TF; Sato, S,期刊：American Journal of Pathology, 页码：1650-1663 , 文章类型： Article，,卷期：2008年172-6]
- Mice subcutaneously injected with bleomycin, in an experimental model of human systemic sclerosis, develop cutaneous and lung fibrosis with autoantibody production. CD19 is a general "rheostat" that defines signaling thr...
- Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen
[作者：Posey, KL; Hankenson, K; Veerisetty, AC; Bornstein, P; Lawler, J; Hecht, JT,期刊：American Journal of Pathology, 页码：1664-1674 , 文章类型： Article，,卷期：2008年172-6]
- Thrombospondin-5 (TSP5) is a large extracellular matrix glycoprotein found in musculoskeletal tissues. TSP5 mutations cause two skeletal dysplasias, pseudoa-chondroplasia and multiple epiphyseal dysplasia; both show a ch...
- Pharmacological blockade of A(2A) receptors prevents dermal fibrosis in a model of elevated tissue adenosine
[作者：Fernandez, P; Trzaska, S; Wilder, T; Chiriboga, L; Blackburn, MR; Cronstein, BN; Chan, ESL,期刊：American Journal of Pathology, 页码：1675-1682 , 文章类型： Article，,卷期：2008年172-6]
- Adenosine is a potent modulator of inflammation and tissue repair. We have recently reported that activation of adenosine A(2A) receptors promotes collagen synthesis by human dermal fibroblasts and that blockade or delet...
- Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes
[作者：Fein, JA; Sokolow, S; Miller, CA; Vinters, HV; Yang, FS; Cole, GM; Gylys, KH,期刊：American Journal of Pathology, 页码：1683-1692 , 文章类型： Article，,卷期：2008年172-6]
- The amyloid cascade hypothesis proposes that amyloid beta (A beta) pathology precedes and induces tau pathology, but the neuropathological connection between these two lesions has not been demonstrated. We examined the r...
- Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration
[作者：Sasahara, M; Otani, A; Oishi, A; Kojima, H; Yodoi, Y; Kameda, T; Nakamura, H; Yoshimura, N,期刊：American Journal of Pathology, 页码：1693-1703 , 文章类型： Article，,卷期：2008年172-6]
- The role of microglia in neurodegeneration is controversial, although microglial activation in the retina has been shown to provide an early response against infection, injury, ischemia, and degeneration. Here we show th...
- Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia
[作者：Adhami, F; Yu, D; Yin, W; Schloemer, A; Burns, KA; Liao, GH; Degen, JL; Chen, J; Kuan, CY,期刊：American Journal of Pathology, 页码：1704-1716 , 文章类型： Article，,卷期：2008年172-6]
- The immature brains of newborns often respond differ ently from the brains of adults when exposed to similar insults. Previous studies have indicated that although by poxia-ischemia (HI) induces persistent thrombosis in ...
- Stat3 promotes metastatic progression of prostate cancer
[作者：Abdulghani, J; Gu, L; Dagvadorj, A; Lutz, J; Leiby, B; Bonuccelli, G; Lisanti, MP; Zellweger, T; Alanen, K; Mirtti, T; Visakorpi, T; Bubendorf, L; Nevalainen, MT,期刊：American Journal of Pathology, 页码：1717-1728 , 文章类型： Article，,卷期：2008年172-6]
- There are currently no effective therapies for metastatic prostate cancer because the molecular mechanisms that underlie the metastatic spread of primary prostate cancer are unclear. Transcription factor Stat3 is constit...
- CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma
[作者：Uekita, T; Tanaka, M; Takigahira, M; Miyazawa, Y; Nakanishi, Y; Kanai, Y; Yanagihara, K; Sakai, R,期刊：American Journal of Pathology, 页码：1729-1739 , 文章类型： Article，,卷期：2008年172-6]
- CUB-domain-containing protein 1 (CDCP1) is a type-I transmembrane protein that is highly expressed in colon, breast, and lung cancers. We recently revealed that CDCP1 is associated with and phosphorylated by Src family k...
- Genetic ablation of alpha v integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma
[作者：McCarty, JH; Barry, M; Crowley, D; Bronson, RT; Lacy-Hulbert, A; Hynes, RO,期刊：American Journal of Pathology, 页码：1740-1747 , 文章类型： Article，,卷期：2008年172-6]
- Integrin-mediated cell adhesion and signaling events are essential for the proper development and homeostasis of most epithelial tissues. Drysregulation of integrin expression and function can cause abnormal epithelial c...
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