- Structural Constraints for the Binding of Short Peptides to Claudin-4 Revealed by Surface Plasmon Resonance
[作者:Ling, J; Liao, HL; Clark, R; Wong, MSM; Lo, DD,期刊:Journal of Biological Chemistry, 页码:30585-30595 , 文章类型: Article,,卷期:2008年283-45]
- Claudin family transmembrane proteins play an important role in tight junction structure and function in epithelial cells. Among the 24 isoforms identified in mice and humans, claudin-4 and -3 serve as the receptor for C...
- Discovery of Mitocryptide-1, a Neutrophil-activating Cryptide from Healthy Porcine Heart
[作者:Mukai, H; Hokari, Y; Seki, T; Takao, T; Kubota, M; Matsuo, Y; Tsukagoshi, H; Kato, M; Kimura, H; Shimonishi, Y; Kiso, Y; Nishi, Y; Wakamatsu, K; Munekata, E,期刊:Journal of Biological Chemistry, 页码:30596-30605 , 文章类型: Article,,卷期:2008年283-45]
- Although neutrophils are known to migrate in response to various chemokines and complement factors, the substances involved in the early stages of their transmigration and activation have been poorly characterized to dat...
- MKP1 Regulates the Induction of MUC5AC Mucin by Streptococcus pneumoniae Pneumolysin by Inhibiting the PAK4-JNK Signaling Pathway
[作者:Ha, UH; Lim, JH; Kim, HJ; Wu, WH; Jin, SG; Xu, HD; Li, JD,期刊:Journal of Biological Chemistry, 页码:30624-30631 , 文章类型: Article,,卷期:2008年283-45]
- Mucosal epithelial cells in the respiratory tract act as the first line of host innate defense against inhaled microbes by producing a range of molecules for clearance. In particular, epithelial mucins facilitate the muc...
- Human Glyceraldehyde-3-phosphate Dehydrogenase Plays a Direct Role in Reactivating Oxidized Forms of the DNA Repair Enzyme APE1
[作者:Azam, S; Jouvet, N; Jilani, A; Vongsamphanh, R; Yang, XM; Yang, S; Ramotar, D,期刊:Journal of Biological Chemistry, 页码:30632-30641 , 文章类型: Article,,卷期:2008年283-45]
- Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has diverse biological functions including its nuclear translocation in response to oxidative stress. We show that GAPDH physically associates with APE1, an essential enzy...
- Inhibition of Gluconeogenesis in Primary Hepatocytes by Stromal Cell-derived Factor-1 (SDF-1) through a c-Src/Akt-dependent Signaling Pathway
[作者:Liu, HY; Wen, GB; Han, JM; Hong, T; Zhuo, DG; Liu, ZQ; Cao, WH,期刊:Journal of Biological Chemistry, 页码:30642-30649 , 文章类型: Article,,卷期:2008年283-45]
- Hepatic gluconeogenesis is elevated in diabetes and a major contributor to hyperglycemia. Stromal cell-derived factor-1 (SDF-1) is a chemokine and an activator of Akt. In this study, we tested the hypothesis that SDF-1 s...
- Cyclin-dependent Kinase 2 Negatively Regulates Human Pregnane X Receptor-mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells
[作者:Lin, WW; Wu, J; Dong, HQ; Bouck, D; Zeng, FY; Chen, TS,期刊:Journal of Biological Chemistry, 页码:30650-30657 , 文章类型: Article,,卷期:2008年283-45]
- The human pregnane X receptor (hPXR) regulates the expression of critical drug metabolism enzymes. One of such enzymes, cytochrome P450 3A4 (CYP3A4), plays critical roles in drug metabolism in hepatocytes that are either...
- Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling
[作者:Wang, XM; Fonseca, BD; Tang, H; Liu, R; Elia, A; Clemens, MJ; Bommer, UA; Proud, CG,期刊:Journal of Biological Chemistry, 页码:30482-30492 , 文章类型: Article,,卷期:2008年283-45]
- Signaling through mammalian target of rapamycin complex 1 (mTORC1) is stimulated by amino acids and insulin. Insulin inactivates TSC1/2, the GTPase-activator complex for Rheb, and Rheb.GTP activates mTORC1. It is not cle...
- Aspergillus fumigatus-induced Interleukin-8 Synthesis by Respiratory Epithelial Cells Is Controlled by the Phosphatidylinositol 3-Kinase, p38 MAPK, and ERK1/2 Pathways and Not by the Toll-like Receptor-MyD88 Pathway
[作者:Balloy, V; Sallenave, JM; Wu, YZ; Touqui, L; Latge, JP; Si-Tahar, M; Chignard, M,期刊:Journal of Biological Chemistry, 页码:30513-30521 , 文章类型: Article,,卷期:2008年283-45]
- Previous studies have established that phagocytes are key cells of the pulmonary innate immune defense against A. fumigatus, an opportunistic fungus responsible of invasive pulmonary aspergillosis. Macrophages detect A. ...
- Agonist-selective, Receptor-specific Interaction of Human P-2Y Receptors with beta-Arrestin-1 and-2
[作者:Hoffmann, C; Ziegler, N; Reiner, S; Krasel, C; Lohse, MJ,期刊:Journal of Biological Chemistry, 页码:30933-30941 , 文章类型: Article,,卷期:2008年283-45]
- Interaction of G-protein-coupled receptors with beta-arrestins is an important step in receptor desensitization and in triggering "alternative" signals. By means of confocal microscopy and fluorescence resonance energy t...
- Structural Insights into the Role of Mutations in Amyloidogenesis
[作者:Baden, EM; Randles, EG; Aboagye, AK; Thompson, JR; Ramirez-Alvarado, M,期刊:Journal of Biological Chemistry, 页码:30950-30956 , 文章类型: Article,,卷期:2008年283-45]
- Mechanisms of amyloidogenesis are not well understood, including potential structural contributions of mutations in the process. Our previous research indicated that the dimer interface of amyloidogenic immunoglobulin li...
- Molecular Cloning and Characterization of the Human PED/PEA-15 Gene Promoter Reveal Antagonistic Regulation by Hepatocyte Nuclear Factor 4 alpha and Chicken Ovalbumin Upstream Promoter Transcription Factor II
[作者:Ungaro, P; Teperino, R; Mirra, P; Cassese, A; Fiory, F; Perruolo, G; Miele, C; Laakso, M; Formisano, P; Beguinot, F,期刊:Journal of Biological Chemistry, 页码:30970-30979 , 文章类型: Article,,卷期:2008年283-45]
- Overexpression of the ped/pea-15 gene in mice impairs glucose tolerance and leads to diabetes in conjunction with high fat diet treatment. PED/PEA-15 is also overexpressed in type 2 diabetics as well as in euglycemic off...
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