个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共89条记录   A New Family of Cyanobacterial Penicillin-binding Proteins A MISSING LINK IN THE EVOLUTION OF CLASS A beta-LACTAMASES [作者：Urbach, C; Fastrez, J; Soumillion, P,期刊：Journal of Biological Chemistry, 页码：32516-32526 , 文章类型： Article，,卷期：2008年283-47] It is largely accepted that serine beta-lactamases evolved from some ancestral DD-peptidases involved in the biosynthesis and maintenance of the bacterial peptidoglycan. DD-peptidases are also called penicillin-binding p... Endoglin Promotes Transforming Growth Factor beta-mediated Smad 1/5/8 Signaling and Inhibits Endothelial Cell Migration through Its Association with GIPC [作者：Lee, NY; Ray, B; How, T; Blobe, GC,期刊：Journal of Biological Chemistry, 页码：32527-32533 , 文章类型： Article，,卷期：2008年283-47] Transforming growth factor beta (TGF-beta) signals through two distinct pathways to regulate endothelial cell proliferation, migration, and angiogenesis, the ALK-1/Smad 1/5/8 and ALK-5/Smad2/3 pathways. Endoglin is a co-... Interaction between the C Termini of Alg13 and Alg14 Mediates Formation of the Active UDP-N-acetylglucosamine Transferase Complex [作者：Gao, XD; Moriyama, S; Miura, N; Dean, N; Nishimura, SI,期刊：Journal of Biological Chemistry, 页码：32534-32541 , 文章类型： Article，,卷期：2008年283-47] The second step of eukaryotic N-linked glycosylation in endoplasmic reticulum is catalyzed by an UDP-N-acetylglucosamine transferase that is comprised of two subunits, Alg13 and Alg14. The interaction between Alg13 and 1... Molecular Dissection of the Mechanisms of Substrate Recognition and F-actin-mediated Activation of Cofilin-phosphatase Slingshot-1 [作者：Kurita, S; Watanabe, Y; Gunji, E; Ohashi, K; Mizuno, K,期刊：Journal of Biological Chemistry, 页码：32542-32552 , 文章类型： Article，,卷期：2008年283-47] Slingshot-1 (SSH1), a member of a dual-specificity protein phosphatase family, regulates actin dynamics by dephosphorylating and reactivating cofilin, an actin-depolymerizing factor. SSH1 has the SSH family-specific, N-t... The p38 Mitogen-activated Protein Kinase Augments Nucleotide Excision Repair by Mediating DDB2 Degradation and Chromatin Relaxation [作者：Zhao, Q; Barakat, BM; Qin, S; Ray, A; El-Mahdy, MA; Wani, G; Arafa, ES; Mir, SN; Wang, QE; Wani, AA,期刊：Journal of Biological Chemistry, 页码：32553-32561 , 文章类型： Article，,卷期：2008年283-47] The p38 MAPK is a family of serine/threonine protein kinases that play important roles in cellular responses to external stress signals, e. g. UV irradiation. To assess the role of p38 MAPK pathway in nucleotide excision... Metabolic Switch and Hypertrophy of Cardiomyocytes following Treatment with Angiotensin II Are Prevented by AMP-activated Protein Kinase [作者：Stuck, BJ; Lenski, M; Bohm, M; Laufs, U,期刊：Journal of Biological Chemistry, 页码：32562-32569 , 文章类型： Article，,卷期：2008年283-47] Angiotensin II induces cardiomyocyte hypertrophy, but its consequences on cardiomyocyte metabolism and energy supply are not completely understood. Here we investigate the effect of angiotensin II on glucose and fatty ac... Organic Anion Transporter OAT1 Undergoes Constitutive and Protein Kinase C-regulated Trafficking through a Dynamin- and Clathrin-dependent Pathway [作者：Zhang, Q; Hong, M; Duan, P; Pan, Z; Ma, JJ; You, GF,期刊：Journal of Biological Chemistry, 页码：32570-32579 , 文章类型： Article，,卷期：2008年283-47] Organic anion transporter 1 (OAT1) mediates the body disposition of a diverse array of environmental toxins and clinically important drugs. Therefore, understanding the regulation of this transporter has profound clinica... Crystal Structure of Human Type III Collagen Gly(991)-Gly(1032) Cystine Knot-containing Peptide Shows Both 7/2 and 10/3 Triple Helical Symmetries [作者：Boudko, SP; Engel, J; Okuyama, K; Mizuno, K; Bachinger, HP; Schumacher, MA,期刊：Journal of Biological Chemistry, 页码：32580-32589 , 文章类型： Article，,卷期：2008年283-47] Type III collagen is a critical collagen that comprises extensible connective tissue such as skin, lung, and the vascular system. Mutations in the type III collagen gene, COL3A1, are associated with the most severe forms... Nitrite Reductase Activity of Cytochrome c [作者：Basu, S; Azarova, NA; Font, MD; King, SB; Hogg, N; Gladwin, MT; Shiva, S; Kim-Shapiro, DB,期刊：Journal of Biological Chemistry, 页码：32590-32597 , 文章类型： Article，,卷期：2008年283-47] Small increases in physiological nitrite concentrations have now been shown to mediate a number of biological responses, including hypoxic vasodilation, cytoprotection after ischemia/reperfusion, and regulation of gene a... Biophysical Characterization of Refolded Drosophila Spatzle, a Cystine Knot Protein, Reveals Distinct Properties of Three Isoforms [作者：Hoffmann, A; Funkner, A; Neumann, P; Juhnke, S; Walther, M; Schierhorn, A; Weininger, U; Balbach, J; Reuter, G; Stubbs, MT,期刊：Journal of Biological Chemistry, 页码：32598-32609 , 文章类型： Article，,卷期：2008年283-47] The Drosophila Spatzle protein, involved in the embryonic development of the dorsal-ventral axis and in the adult immune response, is expressed as a proprotein and is activated by the serine proteinases Easter or Spatzle... Oversulfated Chondroitin Sulfate Plays Critical Roles in the Neuronal Migration in the Cerebral Cortex [作者：Ishii, M; Maeda, N,期刊：Journal of Biological Chemistry, 页码：32610-32620 , 文章类型： Article，,卷期：2008年283-47] Chondroitin sulfate (CS) proteoglycans bind with various proteins through CS chains in a CS structure-dependent manner, in which oversulfated structures, such as iB (IdoA(2-O-sulfate) alpha 1-3GalNAc(4-O-sulfate)), D (Gl... Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins [作者：Putz, U; Howitt, J; Lackovic, J; Foot, N; Kumar, S; Silke, J; Tan, SS,期刊：Journal of Biological Chemistry, 页码：32621-32627 , 文章类型： Article，,卷期：2008年283-47] The ability to remove unwanted proteins is an important cellular feature. Classically, this involves the enzymatic addition of ubiquitin moieties followed by degradation in the proteasome. Nedd4 proteins are ubiquitin li... Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma [作者：Purushothaman, A; Chen, LG; Yang, Y; Sanderson, RD,期刊：Journal of Biological Chemistry, 页码：32628-32636 , 文章类型： Article，,卷期：2008年283-47] High levels of heparanase are an indicator of poor prognosis in myeloma patients, and up-regulation of the enzyme enhances tumor growth, angiogenesis, and metastasis in animal models. At least part of the impact of hepar... Structures of Human Host Defense Cathelicidin LL-37 and Its Smallest Antimicrobial Peptide KR-12 in Lipid Micelles [作者：Wang, GS,期刊：Journal of Biological Chemistry, 页码：32637-32643 , 文章类型： Article，,卷期：2008年283-47] As a key component of the innate immunity system, human cathelicidin LL-37 plays an essential role in protecting humans against infectious diseases. To elucidate the structural basis for its targeting bacterial membrane,... Role of the HIV gp120 Conserved Domain 1 in Processing and Viral Entry [作者：Wang, JZ; Sen, J; Rong, LJ; Caffrey, M,期刊：Journal of Biological Chemistry, 页码：32644-32649 , 文章类型： Article，,卷期：2008年283-47] The importance of the N-terminal region of HIV gp120 conserved domain 1 (gp120-C1) to envelope function has been examined by alanine-scanning mutagenesis and subsequent characterization of the mutagenic effects on viral ... Molecular Mechanism of the Syk Activation Switch [作者：Tsang, E; Giannetti, AM; Shaw, D; Dinh, M; Tse, JKY; Gandhi, S; Ho, HD; Wang, S; Papp, E; Bradshaw, JM,期刊：Journal of Biological Chemistry, 页码：32650-32659 , 文章类型： Article，,卷期：2008年283-47] Many immune signaling pathways require activation of the Syk tyrosine kinase to link ligation of surface receptors to changes in gene expression. Despite the central role of Syk in these pathways, the Syk activation proc...