- Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe
[作者:O'Boyle, NM; Carr, M; Greene, LM; Keely, NO; Knox, AJS; McCabe, T; Lloyd, DG; Zisterer, DM; Meegan, MJ,期刊:European Journal of Medicinal Chemistry, 页码:4595-4607 , 文章类型: Article,,卷期:2011年46-9]
- The structure-activity relationships of antiproliferative beta-lactams, focusing on modifications at the 4-position of the beta-lactam ring, is described. Synthesis of this series of compounds was achieved utilizing the ...
- Cyclolinopeptide derivatives modify methotrexate-induced suppression of the humoral immune response in mice
[作者:Katarzynska, J; Mazur, A; Rudzinska, E; Artym, J; Zimecki, M; Jankowski, S; Zabrocki, J,期刊:European Journal of Medicinal Chemistry, 页码:4608-4617 , 文章类型: Article,,卷期:2011年46-9]
- High doses of chemotherapeutics in clinical treatment, leading to cell toxicity, can be lowered by co-administration of other immunoregulatory drugs. The aim of this study was to evaluate effects of several derivatives o...
- Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives
[作者:Wu, XW; Wu, ZP; Wang, LX; Zhang, HB; Chen, JW; Zhang, W; Gu, LQ; Huang, ZS; An, LK,期刊:European Journal of Medicinal Chemistry, 页码:4625-4633 , 文章类型: Article,,卷期:2011年46-9]
- A series of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives was synthesized. Antimicrobial activity assessment indicates that compounds 1, 26, 27 and 28 exhibit strong activity against gram-positive bacter...
- Synthesis and anticonvulsant properties of new acetamide derivatives of phthalimide, and its saturated cyclohexane and norbornene analogs
[作者:Kaminski, K; Obniska, J; Wiklik, B; Atamanyuk, D,期刊:European Journal of Medicinal Chemistry, 页码:4634-4641 , 文章类型: Article,,卷期:2011年46-9]
- The synthesis and anticonvulsant properties of new piperazine or morpholine acetamides derived from 2-(1,3-dioxoisoindolin-2-yl)-, 2-(1,3-dioxo-3a,4,5,6,7,7a-hexahydroisoindol-2-yl-) and (3,5-dioxo-4-azatricyclo[5.2.1.0(...
- Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents
[作者:Al-Abdullah, ES; Al-Obaid, ARM; Al-Deeb, OA; Habib, EE; El-Emam, AA,期刊:European Journal of Medicinal Chemistry, 页码:4642-4647 , 文章类型: Article,,卷期:2011年46-9]
- New series of 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles namely, 2-substitued thio-6-phenyl-3,4-dihydro-4-oxopyrimidine-5-carbonitriles (5a-d, 6, 7a-d, 8), 2-(4-chlorobenzylthio)-4-chloro-6-phenylpyrimidine-5-...
- Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3, 5-triazin-2(1H)-ones as inhibitors of cathepsin B
[作者:Sosic, I; Mirkovic, B; Turk, S; Stefane, B; Kos, J; Gobec, S,期刊:European Journal of Medicinal Chemistry, 页码:4648-4656 , 文章类型: Article,,卷期:2011年46-9]
- Cathepsin B is a lysosomal cysteine protease that has various physiological and pathophysiological functions. We present here the discovery of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsi...
- Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease
[作者:Samadi, A; Chioua, M; Bolea, I; de los Rios, C; Iriepa, I; Moraleda, I; Bastida, A; Esteban, G; Unzeta, M; Galvez, E; Marco-Contelles, J,期刊:European Journal of Medicinal Chemistry, 页码:4665-4668 , 文章类型: Article,,卷期:2011年46-9]
- The synthesis, biological evaluation and molecular modeling of new multipotent inhibitors of type 1 and type II, able to simultaneously inhibit monoamine oxidases (MAO) as well as acetylcholinesterase (AChE) and butyrylc...
- Synthesis, characterization and biological evaluation of novel 2,4,6-trisubstituted bis-pyrimidine derivatives
[作者:Parveen, H; Hayat, F; Mukhtar, S; Salahuddin, A; Khan, A; Islam, F; Azam, A,期刊:European Journal of Medicinal Chemistry, 页码:4669-4675 , 文章类型: Article,,卷期:2011年46-9]
- A new series of 2,4,6-trisubstituted bis-pyrimidines were synthesized and evaluated for in vitro antiamoebic activity against HM1:IMSS strain of Entamoeba histolytica. Out of 16 compounds 8 compounds have shown IC(50) va...
- Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives
[作者:Silva, D; Chioua, M; Samadi, A; Carreiras, MC; Jimeno, ML; Mendes, E; de los Rios, C; Romero, A; Villarroya, M; Lopez, MG; Marco-Contelles, J,期刊:European Journal of Medicinal Chemistry, 页码:4676-4681 , 文章类型: Article,,卷期:2011年46-9]
- The synthesis and pharmacological analyses of a number of pyrazolo[3,4-b]quinoline and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives are reported. We have synthesized the diversely substituted tacrine analogues 1...
- Synthesis, pharmacological evaluation and docking studies of coumarin derivatives
[作者:Sandhya, B; Giles, D; Mathew, V; Basavarajaswamy, G; Abraham, R,期刊:European Journal of Medicinal Chemistry, 页码:4696-4701 , 文章类型: Article,,卷期:2011年46-9]
- We synthesized coumarin derivatives using various aromatic and heterocyclic amines, and tested the target compound for its analgesic, anti-inflammatory, antimicrobial activities. Compounds 31, 3m and 3n showed significan...
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