- Cation-pi interaction regulates ligand-binding affinity and signaling of integrin alpha(4)beta(7)
[作者:Pan, YP; Zhang, K; Qi, JP; Yue, JA; Springer, TA; Chen, JF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21388-21393 , 文章类型: Article,,卷期:2010年107-50]
- Integrin alpha(4)beta(7) mediates rolling and firm adhesion of leucocytes, two of the critical steps in leukocyte migration and tissue specific homing. Affinity of alpha(4)beta(7) for ligand is dynamically regulated by t...
- Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis
[作者:Auclair, JR; Boggio, KJ; Petsko, GA; Ringe, D; Agar, JN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21394-21399 , 文章类型: Article,,卷期:2010年107-50]
- Amyotrophic lateral sclerosis (ALS) is a disorder characterized by the death of both upper and lower motor neurons and by 3- to 5-yr median survival postdiagnosis. The only US Food and Drug Administration-approved drug f...
- Structural identification of cation binding pockets in the plasma membrane proton pump
[作者:Ekberg, K; Pedersen, BP; Sorensen, DM; Nielsen, AK; Veierskov, B; Nissen, P; Palmgren, MG; Buch-Pedersen, MJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21400-21405 , 文章类型: Article,,卷期:2010年107-50]
- The activity of P-type plasma membrane H+-ATPases is modulated by H+ and cations, with K+ and Ca2+ being of physiological relevance. Using X-ray crystallography, we have located the binding site for Rb+ as a K+ congener,...
- Jumonji domain protein JMJD5 functions in both the plant and human circadian systems
[作者:Jones, MA; Covington, MF; DiTacchio, L; Vollmers, C; Panda, S; Harmer, SL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21623-21628 , 文章类型: Article,,卷期:2010年107-50]
- Circadian clocks are near-ubiquitous molecular oscillators that coordinate biochemical, physiological, and behavioral processes with environmental cues, such as dawn and dusk. Circadian timing mechanisms are thought to h...
- alpha-Dystrobrevin-1 recruits alpha-catulin to the alpha(1D)-adrenergic receptor/dystrophin-associated protein complex signalosome
[作者:Lyssand, JS; Whiting, JL; Lee, KS; Kastl, R; Wacker, JL; Bruchas, MR; Miyatake, M; Langeberg, LK; Chavkin, C; Scott, JD; Gardner, RG; Adams, ME; Hague, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21854-21859 , 文章类型: Article,,卷期:2010年107-50]
- alpha(1D)-Adrenergic receptors (ARs) are key regulators of cardiovascular system function that increase blood pressure and promote vascular remodeling. Unfortunately, little information exists about the signaling pathway...
- Crystal structure of a 117 kDa glucansucrase fragment provides insight into evolution and product specificity of GH70 enzymes
[作者:Vujicic-Zagar, A; Pijning, T; Kralj, S; Lopez, CA; Eeuwema, W; Dijkhuizen, L; Dijkstra, BW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21406-21411 , 文章类型: Article,,卷期:2010年107-50]
- Glucansucrases are large enzymes belonging to glycoside hydrolase family 70, which catalyze the cleavage of sucrose into fructose and glucose, with the concomitant transfer of the glucose residue to a growing alpha-gluca...
- Directed epitope delivery across the Escherichia coli outer membrane through the porin OmpF
[作者:Housden, NG; Wojdyla, JA; Korczynska, J; Grishkovskaya, I; Kirkpatrick, N; Brzozowski, AM; Kleanthous, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21412-21417 , 文章类型: Article,,卷期:2010年107-50]
- The porins OmpF and OmpC are trimeric beta-barrel proteins with narrow channels running through each monomer that exclude molecules > 600 Da while mediating the passive diffusion of small nutrients and metabolites across...
- Helicobacter pylori proinflammatory protein up-regulates NF-kappa B as a cell-translocating Ser/Thr kinase
[作者:Kim, DJ; Park, KS; Kim, JH; Yang, SH; Yoon, JY; Han, BG; Kim, HS; Lee, SJ; Jang, JY; Kim, KH; Kim, MJ; Song, JS; Kim, HJ; Park, CM; Lee, SK; Il Lee, B; Suh, SW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21418-21423 , 文章类型: Article,,卷期:2010年107-50]
- There has been considerable interest in virulence genes in the plasticity region of Helicobacter pylori, but little is known about many of these genes. JHP940, one of the virulence factors encoded by the plasticity regio...
- Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
[作者:Hu, B; Elinav, E; Huber, S; Booth, CJ; Strowig, T; Jin, CC; Eisenbarth, SC; Flavell, RA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21635-21640 , 文章类型: Article,,卷期:2010年107-50]
- Chronic inflammation is a known risk factor for tumorigenesis, yet the precise mechanism of this association is currently unknown. The inflammasome, a multiprotein complex formed by NOD-like receptor (NLR) family members...
- Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression
[作者:Bergthaler, A; Flatz, L; Hegazy, AN; Johnson, S; Horvath, E; Lohning, M; Pinschewer, DD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21641-21646 , 文章类型: Article,,卷期:2010年107-50]
- The Clone 13 (Cl13) strain of lymphocytic choriomeningitis virus is widely studied as a model of chronic systemic viral infection. Here, we used reverse genetic techniques to identify the molecular basis of Cl13 persiste...
- PGC-1 alpha regulates a HIF2 alpha-dependent switch in skeletal muscle fiber types
[作者:Rasbach, KA; Gupta, RK; Ruas, JL; Wu, J; Naseri, E; Estall, JL; Spiegelman, BM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21866-21871 , 文章类型: Article,,卷期:2010年107-50]
- The coactivator peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha) coordinates a broad set of transcriptional programs that regulate the response of skeletal muscle to exercise. However, t...
|