- Brain-penetrating 2-aminobenzimidazole H-1-antihistamines for the treatment of insomnia
[作者:Coon, T; Moree, WJ; Li, BF; Yu, JH; Zamani-Kord, S; Malany, S; Santos, MA; Hernandez, LM; Petroski, RE; Sun, AX; Wen, J; Sullivan, S; Haelewyn, J; Hedrick, M; Hoare, SJ; Bradbury, MJ; Crowe, PD; Beaton, G,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4380-4384 , 文章类型: Article,,卷期:2009年19-15]
- The benzimidazole core of the selective non-brain-penetrating H-1-antihistamine mizolastine was used to identify a series of brain-penetrating H-1-antihistamines for the potential treatment of insomnia. Using cassette PK...
- Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with greater cytotoxic effects in leukemia cells
[作者:Yang, XL; Wang, W; Tan, J; Song, DD; Li, M; Liu, D; Jing, YK; Zhao, LX,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4385-4388 , 文章类型: Article,,卷期:2009年19-15]
- Fifteen dihydroartemisinin derivatives containing a substituted chalcone linked by either ether or ester were synthesized and investigated for their cytotoxicity in human leukemia HL-60 and mouse lymphoma P388 cells. The...
- Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE(2), and TNF-alpha production
[作者:Hung, TM; Dang, NH; Kim, JC; Choi, JS; Lee, HK; Min, BS,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4389-4393 , 文章类型: Article,,卷期:2009年19-15]
- Three new phenolic glycosides, salviifosides A-C (1-3), and three known compounds salicin (4), kaempferol (5), and kaempferol 3-O-beta-D-glucopyranoside (6) were isolated from the leaves of Alangium salviifolium (L.f.) W...
- Structure-activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads
[作者:Shah, BA; Kaur, R; Gupta, P; Kumar, A; Sethi, VK; Andotra, SS; Singh, J; Saxena, AK; Taneja, SC,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4394-4398 , 文章类型: Article,,卷期:2009年19-15]
- Analogues of parthenin were synthesized by substitutions at different reaction centres to establish a structure-activity relationship (SAR). Some of the molecules have displayed significant cytotoxicity in human cervical...
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