- Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate
[作者:HALL MARY P; UNCH JAMES; BINKOWSKI BROCK F; VALLEY MICHAEL P; BUTLER BRAEDEN L; WOOD MONIKA G; OTTO PAUL; ZIMMERMAN KRISTOPHER; VIDUGIRIS GEDIMINAS; MACHLEIDT THOMAS; ROBERS MATTHEW B; BENINK HELENE A; EGGERS CHRISTOPHER T; SLATER MICHAEL R; MEISENHEIMER PONCHO L; KLAUBERT DIETER H; FAN FRANK; ENCELL LANCE P; WOOD KEITH V,期刊:ACS CHEMICAL BIOLOGY, 页码:1848-1857 , 文章类型: Article,,卷期:2012年7-11]
- Bioluminescence methodologies have been extraordinarily useful :due to their high sensitivity, broad: dynamic range, and operational simplicity. These capabilities have been realized largely through incremental adaptatio...
- In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound
[作者:KEATING THOMAS A; NEWMAN JOSEPH V; OLIVIER NELSON B; OTTERSON LINDA G; ANDREWS BETH; BORIACKSJODIN P ANN; BREEN JOHN N; DOIG PETER; DUMAS JACQUES; GANGL ERIC; GREEN OLUYINKA M; GULER SATENIG Y; HENTEMANN MARTIN F; JOSEPHMCCARTHY DIANE; KAWATKAR SAMEER; KUTSCHKE AMY; LOCH JAMES T; MCKENZIE ANDREW R; PRADEEPAN SELVI; PRASAD SWATI; MARTINEZBOTELLA GABRIEL,期刊:ACS CHEMICAL BIOLOGY, 页码:1866-1872 , 文章类型: Article,,卷期:2012年7-11]
- There is an urgent need for new antibacterials that pinpoint novel targets and thereby avoid existing resistance mechanisms. We have created novel synthetic antibacterials through structure-based drug design that specifi...
- Manipulating JNK Signaling with (-)-Zuonin A
[作者:KAOUD TAMER S; PARK HEEKWANG; MITRA SHREYA; YAN CHUNLI; TSENG CHUNCHIA; SHI YUE; JOSE JINEY; TALIAFERRO JULIANA M; LEE KIYOUN; REN PENGYU; HONG JIYONG; DALBY KEVIN N,期刊:ACS CHEMICAL BIOLOGY, 页码:1873-1883 , 文章类型: Article,,卷期:2012年7-11]
- Recently, in a virtual screening strategy to identify new compounds targeting the D-recruitment site (DRS) of the c-Jun N-terminal kinases (JNKs), we identified the natural product (-)-zuonin A. Here we report the asymme...
- Real-Time Noninvasive Imaging of Fatty Acid Uptake in Vivo
[作者:HENKIN AMY H; COHEN ALLISON S; DUBIKOVSKAYA ELENA A; PARK HYO MIN; NIKITIN GENNADY F; AUZIAS MATHIEU G; KAZANTZIS MELISSA; BERTOZZI CAROLYN R; STAHL ANDREAS,期刊:ACS CHEMICAL BIOLOGY, 页码:1884-1891 , 文章类型: Article,,卷期:2012年7-11]
- Detection and quantification of fatty acid fluxes in animal model systems following physiological, pathological, or pharmacological challenges is key to our understanding of complex metabolic networks as these macronutri...
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