- Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives
[作者:De Vita, D; Scipione, L; Tortorella, S; Mellini, P; Di Rienzo, B; Simonetti, G; D'Auria, FD; Panella, S; Cirilli, R; Di Santo, R; Palamara, AT,期刊:European Journal of Medicinal Chemistry, 页码:334-342 , 文章类型: Article,,卷期:2012年49-1]
- A new series of aromatic ester and carbamate derivatives of 2-(1H-imidazol-1-yl)-1-phenylethanol were synthesized and evaluated for their antifungal activity towards Candida albicans and non-albicans Candida species stra...
- Exploration of alpha-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases
[作者:Wang, QM; Zhu, ML; Zhu, RT; Lu, LP; Yuan, CX; Xing, S; Fu, XQ; Mei, YH; Hang, QW,期刊:European Journal of Medicinal Chemistry, 页码:354-364 , 文章类型: Article,,卷期:2012年49-1]
- Seventeen alpha-aminophosphonates are synthesized. Their compositions and structures are established by EA, UV, FT-IR, (1)H NMR, (13)C NMR, (31)P NMR and ESI-MS. Compounds 1-4 are confirmed by X-ray crystallography. PIP ...
- Novel hybrid molecules based on 15-membered azalide as potential antimalarial agents
[作者:Starcevic, K; Pesic, D; Toplak, A; Landek, G; Alihodzic, S; Herreros, E; Ferrer, S; Spaventi, R; Peric, M,期刊:European Journal of Medicinal Chemistry, 页码:365-378 , 文章类型: Article,,卷期:2012年49-1]
- Malaria remains the most prevalent tropical disease, and due to the spread of resistant parasites novel therapeutics are urgently needed. Azithromycin has shown potential in malaria treatment so we designed hybrid azalid...
- Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues : A novel DYRK1A inhibitor class
[作者:Neagoie, C; Vedrenne, E; Buron, F; Merour, JY; Rosca, S; Bourg, S; Lozach, O; Meijer, L; Baldeyrou, B; Lansiaux, A; Routier, S,期刊:European Journal of Medicinal Chemistry, 页码:379-396 , 文章类型: Article,,卷期:2012年49-1]
- A library of substituted chromeno[3,4-b]indoles was developed as Lamellarin isosters. Synthesis was achieved from indoles after a four-step pathway sequence involving C-3 iodination, a Suzuki cross-coupling reaction, and...
- Antiproliferative activity against human non-small cell lung cancer of two O-alkyl-diglycosylglycerols from the marine sponges Myrmekioderrna dendyi and Trikentrion laeve
[作者:Farokhi, F; Wielgosz-Collin, G; Robic, A; Debitus, C; Malleter, M; Roussakis, C; Kornprobst, JM; Barnathan, G,期刊:European Journal of Medicinal Chemistry, 页码:406-410 , 文章类型: Article,,卷期:2012年49-1]
- Glycolipids of Myrmekioderma sponges contain Myrmekiosides, a new family of glycolipids with a unique structure of mono-O-alkyl-diglycosylglycerols. This report deals with the identification and biological activity of th...
- New heterocyclic compounds from 1,2,4-triazole and 1,3,4-thiadiazole class bearing diphenylsulfone moieties. Synthesis, characterization and antimicrobial activity evaluation
[作者:Barbuceanu, SF; Saramet, G; Almajan, GL; Draghici, C; Barbuceanu, F; Bancescu, G,期刊:European Journal of Medicinal Chemistry, 页码:417-423 , 文章类型: Article,,卷期:2012年49-1]
- Some new 5-(4-(4-X-phenylsulfonyl)phenyl)-4-(R)-2H-1,2,4-triazol-3(4H)-thiones 4a,b; 5a,b and 5-(4-(4-X-phenylsulfonyl)phenyl)-N-(R)-1,3,4-thiadiazol-2-amines 6a,b; 7a,b were obtained by cyclization of new N(1)-[4-(4-X-p...
- Recent advances in antitubercular natural products
[作者:Garcia, A; Bocanegra-Garcia, V; Palma-Nicolas, JP; Rivera, G,期刊:European Journal of Medicinal Chemistry, 页码:1-23 , 文章类型: Review,,卷期:2012年49-1]
- Currently, one third of the world's population is infected with Mycobacterium tuberculosis and 8.9-9.9 million new and relapse cases of tuberculosis are reported every year. The emergence of new cases, the increased inci...
- Antiproliferative effect of novel platinum(II) and palladium(II) complexes on hepatic tumor stem cells in vitro
[作者:Miklasova, N; Fischer-Fodor, E; Lonnecke, P; Tomuleasa, CI; Virag, P; Schrepler, MP; Miklas, R; Dumitrescu, LS; Hey-Hawkins, E,期刊:European Journal of Medicinal Chemistry, 页码:41-47 , 文章类型: Article,,卷期:2012年49-1]
- Novel platinum and palladium complexes with (2-isopropoxyphenyl)dicyclohexylarsine and (2-methoxyphenyl)dicyclohexylarsine ligands were synthesized and tested on different tumor cells. Adducts with general formula MX(2)L...
- Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and-7
[作者:Huang, WT; Liu, J; Liu, JF; Hui, L; Ding, YL; Chen, SW,期刊:European Journal of Medicinal Chemistry, 页码:48-54 , 文章类型: Article,,卷期:2012年49-1]
- In order to generate compounds with superior antitumor activity and reduced toxicity, a series of conjugates of deoxypodophyllotoxin and 5-FU were synthesized by coupling 4'-demethyl-4-dexoypodophyllotoxin with N-(5-fluo...
- Bakuchiol derivatives as novel and potent cytotoxic agents: A report
[作者:Majeed, R; Reddy, MV; Chinthakindi, PK; Sangwan, PL; Hamid, A; Chashoo, G; Saxena, AK; Koul, S,期刊:European Journal of Medicinal Chemistry, 页码:55-67 , 文章类型: Article,,卷期:2012年49-1]
- A library of 28 compounds comprising of acyl, amino, halo, nitro, styryl and cyclized derivatives of bakuchiol have been evaluated against a panel of eight human cancer cell lines. Bioevaluation studies have resulted in ...
- Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b] indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI
[作者:Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT,期刊:European Journal of Medicinal Chemistry, 页码:68-73 , 文章类型: Article,,卷期:2012年49-1]
- Several 5,10-dihydroindeno[1,2-b]indole derivatives incorporating methoxy, hydroxyl, and halogen (F, Cl, and Br) moieties on the indene fragment of the molecule were prepared and tested against five carbonic anhydrase (C...
- Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents
[作者:Chen, Y; Liu, HR; Liu, HS; Cheng, M; Xia, P; Qian, KD; Wu, PC; Lai, CY; Xia, Y; Yang, ZY; Morris-Natschke, SL; Lee, KH,期刊:European Journal of Medicinal Chemistry, 页码:74-85 , 文章类型: Article,,卷期:2012年49-1]
- Thirty-five S- and O-substituted 7-mercaptocoumarin (9-23) and 7-hydroxy- or 7-mercapto-chromone (24-43) analogs were designed, synthesized and evaluated in vitro against four human tumor cell lines [KB (nasopharyngeal),...
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