- Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide
[作者:Hatakeyama, S; Sugihara, K; Shibata, TK; Nakayama, J; Akama, TO; Tamura, N; Wong, SM; Bobkov, AA; Takano, Y; Ohyama, C; Fukuda, M; Fukuda, MN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19587-19592 , 文章类型: Article,,卷期:2011年108-49]
- Although numerous carbohydrates play significant roles in mammalian cells, carbohydrate-based drug discovery has not been explored due to the technical difficulty of chemically synthesizing complex carbohydrate structure...
- Molecular basis of dihydrouridine formation on tRNA
[作者:Yu, FT; Tanaka, Y; Yamashita, K; Suzuki, T; Nakamura, A; Hirano, N; Suzuki, T; Yao, M; Tanaka, I,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19593-19598 , 文章类型: Article,,卷期:2011年108-49]
- Dihydrouridine (D) is a highly conserved modified base found in tRNAs from all domains of life. Dihydrouridine synthase (Dus) catalyzes the D formation of tRNA through reduction of uracil base with flavin mononucleotide ...
- Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies
[作者:Mao, XB; Wang, CX; Wu, XK; Ma, XJ; Liu, L; Zhang, L; Niu, L; Guo, YY; Li, DH; Yang, YL; Wang, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19605-19610 , 文章类型: Article,,卷期:2011年108-49]
- We report here the identification of the key sites for the beta structure motifs of the islet amyloid polypeptide (IAPP) analogs by using scanning tunneling microscopy (STM). Duplex folding structures in human IAPP(8-37)...
- Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability
[作者:Wise, DR; Ward, PS; Shay, JES; Cross, JR; Gruber, JJ; Sachdeva, UM; Platt, JM; DeMatteo, RG; Simon, MC; Thompson, CB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19611-19616 , 文章类型: Article,,卷期:2011年108-49]
- Citrate is a critical metabolite required to support both mitochondrial bioenergetics and cytosolic macromolecular synthesis. When cells proliferate under normoxic conditions, glucose provides the acetyl-CoA that condens...
- Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2
[作者:Mahankali, M; Peng, HJ; Henkels, KM; Dinauer, MC; Gomez-Cambronero, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19617-19622 , 文章类型: Article,,卷期:2011年108-49]
- Wehave discovered that the enzymephospholipase D2 (PLD2) binds directly to the small GTPase Rac2, resulting in PLD2 functioning as a guanine nucleotide exchange factor (GEF), because it switches Rac2 from the GDP-bound t...
- P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK)
[作者:Su, LL; Mruk, DD; Lui, WY; Lee, WM; Cheng, CY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19623-19628 , 文章类型: Article,,卷期:2011年108-49]
- The blood-testis barrier (BTB), one of the tightest blood-tissue barriers in the mammalian body, creates an immune-privileged site for postmeiotic spermatid development to avoid the production of antibodies against sperm...
- Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors
[作者:Lee, JH; Choy, ML; Ngo, L; Venta-Perez, G; Marks, PA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19629-19634 , 文章类型: Article,,卷期:2011年108-49]
- Histone deacetylase inhibitors (HDACi) are a new group of anticancer drugs with tumor selective toxicity. Normal cells are relatively resistant to HDACi-induced cell death compared with cancer cells. Previously, we found...
- Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3
[作者:Kwon, NH; Kang, T; Lee, JY; Kim, HH; Kim, HR; Hong, J; Oh, YS; Han, JM; Ku, MJ; Lee, SY; Kim, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19635-19640 , 文章类型: Article,,卷期:2011年108-49]
- Mammalian methionyl-tRNA synthetase (MRS) plays an essential role in initiating translation by transferring Met to initiator tRNA (tRNA(i)(Met)). MRS also provides a cytosolic anchoring site for aminoacyl-tRNA synthetase...
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