- The Antithrombotic Activity of EP224283, a Neutralizable Dual Factor Xa Inhibitor/Glycoprotein IIbIIIa Antagonist, Exceeds That of the Coadministered Parent Compounds
[作者:Hechler, B; Freund, M; Alame, G; Leguay, C; Gaertner, S; Cazenave, JP; Petitou, M; Gachet, C,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:412-420 , 文章类型: Article,,卷期:2011年338-2]
- EP224283 combines in a single molecule idraparinux and tirofiban, which allows obtaining a predictable and sustained antiplatelet effect through the transfer of the pharmacokinetics properties of idraparinux to the anti-...
- The Cytochrome P450 4A/F-20-Hydroxyeicosatetraenoic Acid System: A Regulator of Endothelial Precursor Cells Derived from Human Umbilical Cord Blood
[作者:Guo, AM; Janic, B; Sheng, J; Falck, JR; Roman, RJ; Edwards, PA; Arbab, AS; Scicli, AG,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:421-429 , 文章类型: Article,,卷期:2011年338-2]
- Endothelial progenitor cells (EPCs) contribute to physiological and pathological neovascularization. Previous data have suggested that the cytochrome P450 4A/F (CYP4A/F)-20-hydroxyeicosatetraenoic acid (20-HETE) system r...
- Salt Bridges Overlapping the Gonadotropin-Releasing Hormone Receptor Agonist Binding Site Reveal a Coincidence Detector for G Protein-Coupled Receptor Activation
[作者:Janovick, JA; Pogozheva, ID; Mosberg, HI; Conn, PM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:430-442 , 文章类型: Article,,卷期:2011年338-2]
- G protein-coupled receptors (GPCRs) play central roles in most physiological functions, and mutations in them cause heritable diseases. Whereas crystal structures provide details about the structure of GPCRs, there is li...
- Therapeutic Effects on Atopic Dermatitis by Anti-RelA Short Interfering RNA Combined with Functional Peptides Tat and AT1002
[作者:Uchida, T; Kanazawa, T; Kawai, M; Takashima, Y; Okada, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:443-450 , 文章类型: Article,,卷期:2011年338-2]
- Atopic dermatitis (AD) has high morbidity and poor prognosis because safe and effective treatments are scarce. Recently, short interfering RNA (siRNA) has shown promise as an effective treatment for targeting specific ab...
- Combinatorial Effect of Probucol and Cilostazol in Focal Ischemic Mice with Hypercholesterolemia
[作者:Kim, JH; Park, SH; Bae, SS; Hong, KW; Kim, YD; Park, KP; Choi, BT; Shin, HK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:451-457 , 文章类型: Article,,卷期:2011年338-2]
- Hypercholesterolemia may increase stroke risk by accelerating atherosclerosis, narrowing the luminal diameter in cerebral vessels, and disrupting both vascular endothelial and smooth muscle function. In the present study...
- Hydrogen Sulfide in the Rostral Ventrolateral Medulla Inhibits Sympathetic Vasomotor Tone through ATP-Sensitive K(+) Channels
[作者:Guo, Q; Jin, S; Wang, XL; Wang, R; Xiao, L; He, RR; Wu, YM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:458-465 , 文章类型: Article,,卷期:2011年338-2]
- Hydrogen sulfide (H(2)S) acts as an endogenous gaseous transmitter in the central nervous system and plays important roles in regulating cardiovascular function. The rostral ventrolateral medulla (RVLM) is a putative cri...
- A Calcineurin-Independent Mechanism of Angiogenesis Inhibition by a Nonimmunosuppressive Cyclosporin A Analog
[作者:Nacev, BA; Low, WK; Huang, ZN; Su, TT; Su, Z; Alkuraya, H; Kasuga, D; Sun, W; Trager, M; Braun, M; Fischer, G; Zhang, K; Liu, JO,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:466-475 , 文章类型: Article,,卷期:2011年338-2]
- Cyclosporin A (CsA) is a widely used immunosuppressant drug. Its immunosuppressive activity occurs through the inhibition of the protein phosphatase calcineurin via formation of a ternary complex with cyclophilin A (CypA...
- Compound C Inhibits Vascular Smooth Muscle Cell Proliferation and Migration in an AMP-Activated Protein Kinase-Independent Fashion
[作者:Peyton, KJ; Yu, YJ; Yates, B; Shebib, AR; Liu, XM; Wang, H; Durante, W,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:476-484 , 文章类型: Article,,卷期:2011年338-2]
- 6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrazolo[ 1,5-a] pyrimidine (compound C) is a cell-permeable pyrrazolopyrimidine derivative that acts as a potent inhibitor of AMP-activated protein kinase (AMPK). Al...
- Astragaloside IV Stimulates Angiogenesis and Increases Hypoxia-Inducible Factor-1 alpha Accumulation via Phosphatidylinositol 3-Kinase/Akt Pathway
[作者:Zhang, L; Liu, Q; Lu, L; Zhao, XP; Gao, XM; Wang, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:485-491 , 文章类型: Article,,卷期:2011年338-2]
- Astragaloside IV is the major active constituent of Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases in China. The aim of this study was to determine the angiogenic effect ...
- The Role of Hypoxia-Inducible Factor-1 alpha in Acetaminophen Hepatotoxicity
[作者:Sparkenbaugh, EM; Saini, Y; Greenwood, KK; LaPres, JJ; Luyendyk, JP; Copple, BL; Maddox, JF; Ganey, PE; Roth, RA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:492-502 , 文章类型: Article,,卷期:2011年338-2]
- Hypoxia-inducible factor-1 alpha 9HIF-1 alpha) is a critical transcription factor that controls oxygen homeostasis in response to hypoxia, inflammation, and oxidative stress. HIF has been implicated in the pathogenesis o...
- NADPH Oxidase Pathway Is Involved in Aortic Contraction Induced by A(3) Adenosine Receptor in Mice
[作者:El-Awady, MS; Ansari, HR; Fil, D; Tilley, SL; Mustafa, SJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:711-717 , 文章类型: Article,,卷期:2011年338-2]
- The NADPH oxidase (Nox) subunits 1, 2 (gp91 phox), and 4 are the major sources for reactive oxygen species (ROS) in vascular tissues. In conditions such as ischemia-reperfusion and hypoxia, both ROS and adenosine are rel...
- Influence of Dosing Time on the Efficacy and Safety of Finasteride in Rats
[作者:Kumazaki, M; Ando, H; Ushijima, K; Maekawa, T; Motosugi, Y; Takada, M; Tateishi, M; Fujimura, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:718-723 , 文章类型: Article,,卷期:2011年338-2]
- Finasteride (FIN), a widely used medication for the treatment of androgen-dependent diseases, blocks the conversion of testosterone to a more potent androgen, dihydrotestosterone (DHT). In this study, we investigated a d...
- Exposure to an Environmental Neurotoxicant Hastens the Onset of Amyotrophic Lateral Sclerosis-Like Phenotype in Human Cu(2+)/Zn(2+) Superoxide Dismutase 1 G93A Mice: Glutamate-Mediated Excitotoxicity
[作者:Johnson, FO; Yuan, YK; Hajela, RK; Chitrakar, A; Parsell, DM; Atchison, WD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:518-527 , 文章类型: Article,,卷期:2011年338-2]
- Mice expressing the human Cu(2+)/Zn(2+) superoxide dismutase 1 (hSOD1) gene mutation (hSOD1(G93A); G93A) were exposed to methylmercury (MeHg) at concentrations that did not cause overt motor dysfunction. We hypothesized ...
- Intermediate-Conductance Ca(2+)-Activated K(+) Channel, K(Ca)3.1, as a Novel Therapeutic Target for Benign Prostatic Hyperplasia
[作者:Ohya, S; Niwa, S; Kojima, Y; Sasaki, S; Sakuragi, M; Kohri, K; Imaizumi, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:528-536 , 文章类型: Article,,卷期:2011年338-2]
- Recently, a new experimental stromal hyperplasia animal model corresponding to clinical benign prostatic hyperplasia (BPH) was established. The main objective of this study was to elucidate the roles of the intermediate-...
- Oxaliplatin Transport Mediated by Organic Cation/Carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons
[作者:Jong, NN; Nakanishi, T; Liu, JJ; Tamai, I; McKeage, MJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:537-547 , 文章类型: Article,,卷期:2011年338-2]
- The organic cation/carnitine transporters OCTN1 and OCTN2 are related to other organic cation transporters (OCT1, OCT2, and OCT3) known for transporting oxaliplatin, an anticancer drug with dose-limiting neurotoxicity. I...
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