- Structural insights into the dual substrate specificities of mammalian and Dictyostelium dihydropteridine reductases toward two stereoisomers of quinonoid dihydrobiopterin
[作者:Chen, C; Kim, HL; Zhuang, NN; Seo, KH; Park, KH; Han, CD; Park, YS; Lee, KH,期刊:FEBS Letters, 页码:2640-2646 , 文章类型: Article,,卷期:2011年585-17]
- Up to now, D-threo-tetrahydrobiopterin (DH4, dictyopterin) was detected only in Dictyostelium discoideum, while the isomer L-erythro-tetrahydrobioterin (BH4) is common in mammals. To elucidate the mechanism of DH4 regene...
- Phospholipid scramblase 1 mediates hepatitis C virus entry into host cells
[作者:Gong, QL; Cheng, M; Chen, H; Liu, XY; Si, YH; Yang, Y; Yuan, YZ; Jin, CZ; Yang, W; He, FC; Wang, J,期刊:FEBS Letters, 页码:2647-2652 , 文章类型: Article,,卷期:2011年585-17]
- Hepatitis C virus (HCV) infects human hepatocytes through several host factors. However, other prerequisite factors for viral entry remain to be identified. Using a yeast two-hybrid screen, we found that human phospholip...
- Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I-2(PP2A)/SET
[作者:Arnaud, L; Chen, S; Liu, F; Li, B; Khatoon, S; Grundke-Iqbal, I; Iqbal, K,期刊:FEBS Letters, 页码:2653-2659 , 文章类型: Article,,卷期:2011年585-17]
- Protein phosphatase-2A (PP2A) activity, which is compromised in Alzheimer disease brain, is regulated by two endogenous inhibitors, one of them being I-2(PP2A), a 277 amino acid long protein also known as SET. Here we re...
- Anti-HIV siamycin I directly inhibits autophosphorylation activity of the bacterial FsrC quorum sensor and other ATP-dependent enzyme activities
[作者:Ma, P; Nishiguchi, K; Yuille, HM; Davis, LM; Nakayama, J; Phillips-Jones, MK,期刊:FEBS Letters, 页码:2660-2664 , 文章类型: Article,,卷期:2011年585-17]
- Siamycin I disrupts growth and quorum sensing in Enterococcus faecalis. Using purified intact protein, we demonstrate here that quorum membrane sensor kinase FsrC is a direct target of siamycin I, reducing pheromone-stim...
- Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase
[作者:Kokkola, T; Kruse, C; Roy-Pogodzik, EM; Pekkinen, J; Bauch, C; Honck, HH; Hennemann, H; Kreienkamp, HJ,期刊:FEBS Letters, 页码:2665-2670 , 文章类型: Article,,卷期:2011年585-17]
- Many G-protein coupled receptors are palmitoylated in their C-terminal, intracellular regions. So far no enzymes responsible for this modification have been described. We identified an interaction of the membrane proxima...
- Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53
[作者:Hsueh, KW; Fu, SL; Huang, CYF; Lin, CH,期刊:FEBS Letters, 页码:2671-2675 , 文章类型: Article,,卷期:2011年585-17]
- Amplification of Aurora-A, encoding a cell cycle-regulating kinase, has been reported in human cancers. Although Aurora-A is known to directly phosphorylate and down-regulate p53, the detailed mechanism remains unclear. ...
- MEMO associated with an ErbB2 receptor phosphopeptide reveals a new phosphotyrosine motif
[作者:Feracci, M; Pimentel, C; Bornet, O; Roche, P; Salaun, D; Badache, A; Guerlesquin, F,期刊:FEBS Letters, 页码:2688-2692 , 文章类型: Article,,卷期:2011年585-17]
- Tyrosine phosphorylations are essential in signal transduction. Recently, a new type of phosphotyrosine binding protein, MEMO (Mediator of ErbB2-driven cell motility), has been reported to bind specifically to an ErbB2-d...
- Identification of a novel Arabidopsis thaliana nitric oxide-binding molecule with guanylate cyclase activity in vitro
[作者:Mulaudzi, T; Ludidi, N; Ruzvidzo, O; Morse, M; Hendricks, N; Iwuoha, E; Gehring, C,期刊:FEBS Letters, 页码:2693-2697 , 文章类型: Article,,卷期:2011年585-17]
- While there is evidence of nitric oxide (NO)-dependent signalling via the second messenger cyclic guanosine 3',5'-monophosphate (cGMP) in plants, guanylate cyclases (GCs), enzymes that catalyse the formation of cGMP from...
- Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line
[作者:Nevoux, J; Teixeira, M; Viengchareun, S; Cosson, C; Butlen, D; Lombes, M; Ferrary, E,期刊:FEBS Letters, 页码:2703-2708 , 文章类型: Article,,卷期:2011年585-17]
- A strict control of endolymph composition (high potassium, low sodium fluid) and volume is instrumental for a proper functioning of the inner ear. Alteration of endolymph homeostasis is proposed in the pathogenesis of Me...
- BH3-only protein Bim inhibits activity of antiapoptotic members of Bcl-2 family when expressed in yeast
[作者:Juhasova, B; Mentel, M; Bhatia-Kissova, I; Zeman, I; Kolarov, J; Forte, M; Polcic, P,期刊:FEBS Letters, 页码:2709-2713 , 文章类型: Article,,卷期:2011年585-17]
- Proteins of the Bcl-2 family regulate programmed cell death in mammals by promoting the release of cytochrome c from mitochondria in response to various proapoptotic stimuli. The mechanism by which BH3-only members of th...
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