- Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis
[作者:Lee, JN; Kim, H; Yao, HB; Chen, Y; Weng, K; Ye, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21424-21429 , 文章类型: Article,,卷期:2010年107-50]
- Fatty acids (FAs) are essential for cell survival, yet their overaccumulation causes lipotoxicity. To prevent lipotoxicity, cells store excess FAs as triglycerides (TGs). In cultured cells TG synthesis is activated by ex...
- Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery
[作者:Xu, XM; Turanov, AA; Carlson, BA; Yoo, MH; Everley, RA; Nandakumar, R; Sorokina, I; Gygi, SP; Gladyshev, VN; Hatfield, DL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21430-21434 , 文章类型: Article,,卷期:2010年107-50]
- Cysteine (Cys) is inserted into proteins in response to UGC and UGU codons. Herein, we show that supplementation of mammalian cells with thiophosphate led to targeted insertion of Cys at the UGA codon of thioredoxin redu...
- Activation and intrinsic gamma-secretase activity of presenilin 1
[作者:Ahn, K; Shelton, CC; Tian, YA; Zhang, XL; Gilchrist, ML; Sisodia, SS; Li, YM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21435-21440 , 文章类型: Article,,卷期:2010年107-50]
- A complex composed of presenilin (PS), nicastrin, PEN-2, and APH-1 is absolutely required for gamma-secretase activity in vivo. Evidence has emerged to suggest a role for PS as the catalytic subunit of gamma-secretase, b...
- Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15R alpha complexes
[作者:Elpek, KG; Rubinstein, MP; Bellemare-Pelletier, A; Goldrath, AW; Turley, SJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21647-21652 , 文章类型: Article,,卷期:2010年107-50]
- Cytotoxic lymphocytes such as natural killer (NK) and CD8T cells play important roles in immunosurveillance by killing virally infected or malignant cells. The homeostatic cytokine, IL-15, promotes the development, funct...
- Deletion of hensin/DMBT1 blocks conversion of beta- to alpha-intercalated cells and induces distal renal tubular acidosis
[作者:Gao, XB; Eladari, D; Leviel, F; Tew, BY; Miro-Julia, C; Cheema, F; Miller, L; Nelson, R; Paunescu, TG; McKee, M; Brown, D; Al-Awqati, Q,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21872-21877 , 文章类型: Article,,卷期:2010年107-50]
- Acid-base transport in the renal collecting tubule is mediated by two canonical cell types: the beta-intercalated cell secretes HCO3 by an apical Cl:HCO3 named pendrin and a basolateral vacuolar (V)-ATPase. Acid secretio...
- Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood
[作者:Sanchez-Cardenas, C; Fontanaud, P; He, ZH; Lafont, C; Meunier, AC; Schaeffer, M; Carmignac, D; Molino, F; Coutry, N; Bonnefont, X; Gouty-Colomer, LA; Gavois, E; Hodson, DJ; Le Tissier, P; Robinson, ICAF; Mollard, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21878-21883 , 文章类型: Article,,卷期:2010年107-50]
- There are well-recognized sex differences in many pituitary endocrine axes, usually thought to be generated by gonadal steroid imprinting of the neuroendocrine hypothalamus. However, the recognition that growth hormone (...
- Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17
[作者:Pfefferkorn, CM; McGlinchey, RP; Lee, JC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21447-21452 , 文章类型: Article,,卷期:2010年107-50]
- Pmel17 is a functional amyloidogenic protein whose fibrils act as scaffolds for pigment deposition in human skin and eyes. We have used the repeat domain (RPT, residues 315-444), an essential luminal polypeptide region o...
- Relaxation mechanisms of UV-photoexcited DNA and RNA nucleobases
[作者:Barbatti, M; Aquino, AJA; Szymczak, JJ; Nachtigallova, D; Hobza, P; Lischka, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21453-21458 , 文章类型: Article,,卷期:2010年107-50]
- A comprehensive effort in photodynamical ab initio simulations of the ultrafast deactivation pathways for all five nucleobases adenine, guanine, cytosine, thymine, and uracil is reported. These simulations are based on a...
- Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells
[作者:Raghuvanshi, S; Sharma, P; Singh, S; Van Kaer, L; Das, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21653-21658 , 文章类型: Article,,卷期:2010年107-50]
- Tuberculosis (TB) is the cause of 2 million deaths each year, which is the second highest cause of mortality from a single infectious disease worldwide. Resistance of these organisms to drugs has emerged as an important ...
- The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes
[作者:Bellora, F; Castriconi, R; Dondero, A; Reggiardo, G; Moretta, L; Mantovani, A; Moretta, A; Bottino, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21659-21664 , 文章类型: Article,,卷期:2010年107-50]
- The cross-talk among cells of the innate immunity can greatly affect both innate and adaptive responses. Here we analyzed the molecular interactions between human natural killer (NK) cells and autologous macrophages. Act...
- Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl
[作者:Lu, J; Chiang, J; Iyer, RR; Thompson, E; Kaneski, CR; Xu, DS; Yang, CZ; Chen, M; Hodes, RJ; Lonser, RR; Brady, RO; Zhuang, ZP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21665-21670 , 文章类型: Article,,卷期:2010年107-50]
- Gaucher disease (GD), the most common lysosomal storage disorder of humans, is caused by mutations in the gene coding for the enzyme glucocerebrosidase (GCase). Clinical manifestations vary among patients with the three ...
- Identification of 9-cis-retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretion
[作者:Kane, MA; Folias, AE; Pingitore, A; Perri, M; Obrochta, KM; Krois, CR; Cione, E; Ryu, JY; Napoli, JL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21884-21889 , 文章类型: Article,,卷期:2010年107-50]
- The all-trans-retinoic acid (atRA) isomer, 9-cis-retinoic acid (9cRA), activates retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in vitro. RARs control multiple genes, whereas RXRs serve as partners for RA...
- ADP-ribosylation factor machinery mediates endocytosis in plant cells
[作者:Naramoto, S; Kleine-Vehn, J; Robert, S; Fujimoto, M; Dainobu, T; Paciorek, T; Ueda, T; Nakano, A; Van Montagu, MCE; Fukuda, H; Friml, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21890-21895 , 文章类型: Article,,卷期:2010年107-50]
- Endocytosis is crucial for various cellular functions and development of multicellular organisms. In mammals and yeast, ADP-ribosylation factor (ARF) GTPases, key components of vesicle formation, and their regulators ARF...
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