- Mitofusin-2 is a novel direct target of p53
[作者:Wang, WL; Cheng, XF; Lu, JJ; Wei, JF; Fu, GH; Zhu, F; Jia, CK; Zhou, L; Xie, HY; Zheng, SS,期刊:Biochemical and Biophysical Research Communications, 页码:587-592 , 文章类型: Article,,卷期:2010年400-4]
- The tumor suppressor p53 modulates transcription of a number of target genes involved in cell cycle arrest, apoptosis, DNA repair, and other important cellular responses. Mitofusin-2 (Mfn2) is a novel suppressor of cell ...
- MRP4 knockdown enhances migration, suppresses apoptosis, and produces aggregated morphology in human retinal vascular endothelial cells
[作者:Tagami, M; Kusuhara, S; Imai, H; Uemura, A; Honda, S; Tsukahara, Y; Negi, A,期刊:Biochemical and Biophysical Research Communications, 页码:593-598 , 文章类型: Article,,卷期:2010年400-4]
- The multidrug resistance protein (MRP) MRP4/ABCC4 is an ATP-binding cassette transporter that actively effluxes endogenous and xenobiotic substrates out of cells. In the rodent retina, Mrp4 mRNA and protein are exclusive...
- Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats
[作者:Bargo, S; Raafat, A; McCurdy, D; Amirjazil, I; Shu, YM; Traicoff, J; Plant, J; Vonderhaar, BK; Callahan, R,期刊:Biochemical and Biophysical Research Communications, 页码:606-612 , 文章类型: Article,,卷期:2010年400-4]
- We have identified the transforming acidic coiled-coil protein-3 (Tacc3) as a binding partner for Notch4/Int3 and were able to show that it binds to the intracellular domain (ICD) of all members of the Notch receptor fam...
- Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16
[作者:Wang, XM; Wang, XY; Li, LD; Wang, DQ,期刊:Biochemical and Biophysical Research Communications, 页码:613-618 , 文章类型: Article,,卷期:2010年400-4]
- Dimethyl sulfoxide (DMSO) is an important solvent that is widely used in industry and medical studies, as well as in the study of aging, in which it is used as a negative control for lifespan assays; however, our data sh...
- Potent in vivo suppression of inflammation by selectively targeting the high affinity conformation of integrin alpha 4 beta 1
[作者:Vanderslice, P; Woodside, DG; Caivano, AR; Decker, ER; Munsch, CL; Sherwood, SJ; LeJeune, WS; Miyamoto, YJ; McIntyre, BW; Tilton, RG; Dixon, RAF,期刊:Biochemical and Biophysical Research Communications, 页码:619-624 , 文章类型: Article,,卷期:2010年400-4]
- The development of antagonists to the alpha 4 integrin family of cell adhesion molecules has been an active area of pharmaceutical research to treat inflammatory and autoimmune diseases. Presently being tested in human c...
- Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Sp1
[作者:Imanishi, M; Imamura, C; Higashi, C; Yan, W; Negi, S; Futaki, S; Sugiura, Y,期刊:Biochemical and Biophysical Research Communications, 页码:625-630 , 文章类型: Article,,卷期:2010年400-4]
- In contrast to the extensive understanding of the zinc finger-DNA interactions, less is known about zinc finger-zinc finger interactions. GATA-1 and Sp1 are transcription factors with zinc finger domains for DNA binding....
- Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi
[作者:Kubo, K; Tomita, K; Uto, A; Kuroda, K; Seshadri, S; Cohen, J; Kaibuchi, K; Kamiya, A; Nakajima, K,期刊:Biochemical and Biophysical Research Communications, 页码:631-637 , 文章类型: Article,,卷期:2010年400-4]
- Disrupted-in-Schizophrenia I (DISC1) is a promising genetic risk factor for major mental disorders. Many groups repeatedly reported a role for DISC1 in brain development in various strains of mice and rats by using RNA i...
- Modulation of the mechano-chemical properties of myosin V by drebrin-E
[作者:Kubota, H; Ishikawa, R; Ohki, T; Ishizuka, J; Mikhailenko, SV; Ishiwata, S,期刊:Biochemical and Biophysical Research Communications, 页码:643-648 , 文章类型: Article,,卷期:2010年400-4]
- The regulation of actin filament networks by various proteins has essential roles in the growth cone dynamics. In this study we focused on the actin-myosin interaction which has been suggested to be an important player i...
- Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53
[作者:Amaral, JD; Castro, RE; Sola, S; Steer, CJ; Rodrigues, CMP,期刊:Biochemical and Biophysical Research Communications, 页码:649-654 , 文章类型: Article,,卷期:2010年400-4]
- p53/Mdm-2 interaction is a prime target of ursodeoxycholic acid (UDCA) for regulating apoptosis in primary rat hepatocytes. Here, we further explored the role of UDCA in downregulating p53 by Mdm-2. UDCA reduced the stab...
- Production of human CD59-transgenic pigs by embryonic germ cell nuclear transfer
[作者:Ahn, KS; Won, JY; Park, JK; Sorrell, AM; Heo, SY; Kang, JH; Woo, JS; Choi, BH; Chang, WK; Shim, H,期刊:Biochemical and Biophysical Research Communications, 页码:667-672 , 文章类型: Article,,卷期:2010年400-4]
- This study was performed to produce transgenic pigs expressing the human complement regulatory protein CD59 (hCD59) using the nuclear transfer (NT) of embryonic germ (EG) cells, which are undifferentiated stem cells deri...
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