- Keratin Variants Predispose to Acute Liver Failure and Adverse Outcome: Race and Ethnic Associations
[作者:Strnad, P; Zhou, Q; Hanada, S; Lazzeroni, LC; Zhong, BH; So, P; Davern, TJ; Lee, WM; Omary, MB,期刊:Gastroenterology, 页码:828-U175 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: Keratins 8 and 18 (K8/K18) provide anti-apoptotic functions upon liver injury. The cytoprotective function of keratins explains the overrepresentation of K8/K18 variants in patients with cirrhosis. How...
- Genetic Covariance Between gamma-Glutamyl Transpeptidase and Fatty Liver Risk Factors: Role of beta(2)-Adrenergic Receptor Genetic Variation in Twins
[作者:Loomba, R; Rao, FW; Zhang, LA; Khandrika, S; Ziegler, MG; Brenner, DA; O'Connor, DT,期刊:Gastroenterology, 页码:836-U186 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: Plasma levels of gamma-glutamyl transpeptidase (GGT) are associated with risk factors for nonalcoholic fatty liver disease (NAFLD), such as dyslipidemia, insulin resistance (IR), and hypertension. Limi...
- Fatty Acid Metabolism in the Liver, Measured by Positron Emission Tomography, Is Increased in Obese Individuals
[作者:Iozzo, P; Bucci, M; Roivainen, A; Nagren, K; Jarvisalo, MJ; Kiss, J; Guiducci, L; Fielding, B; Naum, AG; Borra, R; Virtanen, K; Savunen, T; Salvadori, PA; Ferrannini, E; Knuuti, J; Nuutila, P,期刊:Gastroenterology, 页码:846-U203 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: Hepatic lipotoxicity results from and contributes to obesity-related disorders. It is a challenge to study human metabolism of fatty acids (FAs) in the liver. We combined C-11-palmitate imaging by posi...
- Glucagon-Like Peptide-2 Receptor Modulates Islet Adaptation to Metabolic Stress in the ob/ob Mouse
[作者:Bahrami, J; Longuet, C; Baggio, LL; Li, K; Drucker, DJ,期刊:Gastroenterology, 页码:857-868 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: Glucagon-like peptide-2 (GLP-2) is a gut hormone that increases gut growth, reduces mucosal cell death, and augments mesenteric blood flow and nutrient absorption. Exogenous GLP-2(1-33) also stimulates...
- Phosphoinositide 3-Kinase Signaling Mediates beta-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis
[作者:Lee, G; Goretsky, T; Managlia, E; Dirisina, R; Singh, AP; Brown, JB; May, R; Yang, GY; Ragheb, JW; Evers, BM; Weber, CR; Turner, JR; He, XC; Katzman, RB; Li, LH; Barrett, TA,期刊:Gastroenterology, 页码:869-U237 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that serine/threonine protein kinase Akt (Akt) signaling cooperates ...
- Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease
[作者:Takayama, T; Kamada, N; Chinen, H; Okamoto, S; Kitazume, MT; Chang, J; Matuzaki, Y; Suzuki, S; Sugita, A; Koganei, K; Hisamatsu, T; Kanai, T; Hibi, T,期刊:Gastroenterology, 页码:882-U251 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: Mucosal natural killer (NK) cells that produce interleukin (IL)-22 mediate intestinal homeostasis and inflammation in mice. However, their role in the pathogenesis of human inflammatory bowel diseases ...
- Indian Hedgehog Regulates Intestinal Stem Cell Fate Through Epithelial-Mesenchymal Interactions During Development
[作者:Kosinski, C; Stange, DE; Xu, CR; Chan, AS; Ho, C; Yuen, ST; Mifflin, RC; Powell, DW; Clevers, H; Leung, SY; Chen, X,期刊:Gastroenterology, 页码:893-903 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: Intestinal stem cells (ISCs) are regulated by the mesenchymal environment via physical interaction and diffusible factors. We examined the role of Indian hedgehog (Ihh) in mesenchymal organization and ...
- Nucleotide-Binding Oligomerization Domain-2 Inhibits Toll-Like Receptor-4 Signaling in the Intestinal Epithelium
[作者:Richardson, WM; Sodhi, CP; Russo, A; Siggers, RH; Afrazi, A; Gribar, SC; Neal, MD; Dai, SP; Prindle, T; Branca, M; Ma, CR; Ozolek, J; Hackam, DJ,期刊:Gastroenterology, 页码:904-U282 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: Factors that regulate enterocyte apoptosis in necrotizing enterocolitis (NEC) remain incompletely understood, although Toll-like receptor-4 (TLR4) signaling in enterocytes plays a major role. Nucleotid...
- Atonal Homolog 1 Is Required for Growth and Differentiation Effects of Notch/gamma-Secretase Inhibitors on Normal and Cancerous Intestinal Epithelial Cells
[作者:Kazanjian, A; Noah, T; Brown, D; Burkart, J; Shroyer, NF,期刊:Gastroenterology, 页码:918-U299 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: The atonal homolog 1 (Atoh1) transcription factor is required for intestinal secretory (goblet, Paneth, enteroendocrine) cell differentiation. Notch/gamma-secretase inhibitors (GSIs) block proliferatio...
- F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor
[作者:Sancho, R; Jandke, A; Davis, H; Diefenbacher, ME; Tomlinson, I; Behrens, A,期刊:Gastroenterology, 页码:929-941 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: The E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (Fbw7) degrades several proto-oncogenes including c-Myc, cyclinE, Notch1, and c-Jun. Fbw7 is the fourth most frequently mutated gene in h...
- Kit(low) Stem Cells Cause Resistance to Kit/Platelet-Derived Growth Factor alpha Inhibitors in Murine Gastrointestinal Stromal Tumors
[作者:Bardsley, MR; Horvath, VJ; Asuzu, DT; Lorincz, A; Redelman, D; Hayashi, Y; Popko, LN; Young, DL; Lomberk, GA; Urrutia, RA; Farrugia, G; Rubin, BP; Ordog, T,期刊:Gastroenterology, 页码:942-952 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: Gastrointestinal stromal tumors (GIST) are related to interstitial cells of Cajal (ICC) and often contain activating stem cell factor receptor (Kit) or platelet-derived growth factor receptor alpha (Pd...
- Monoclonal Anti-Claudin 1 Antibodies Prevent Hepatitis C Virus Infection of Primary Human Hepatocytes
[作者:Fofana, I; Krieger, SE; Grunert, F; Glauben, S; Xiao, F; Fafi-Kremer, S; Soulier, E; Royer, C; Thumann, C; Mee, CJ; McKeating, JA; Dragic, T; Pessaux, P; Stoll-Keller, F; Schuster, C; Thompson, J; Baumert, TF,期刊:Gastroenterology, 页码:953-U339 , 文章类型: Article,,卷期:2010年139-3]
- BACKGROUND & AIMS: Hepatitis C virus (HCV) infection is a challenge to prevent and treat because of the rapid development of drug resistance and escape. Viral entry is required for initiation, spread, and maintenance of ...
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