- Adiponectin-Mediated Heme Oxygenase-1 Induction Protects Against Iron-Induced Liver Injury via a PPAR alpha-Dependent Mechanism
[作者:Lin, H; Yu, CH; Jen, CY; Cheng, CF; Chou, Y; Chang, CC; Juan, SH,期刊:American Journal of Pathology, 页码:1697-1709 , 文章类型: Article,,卷期:2010年177-4]
- Protective effects of adiponectin (APN; an adipocytokine) were shown against various oxidative challenges; however, its therapeutic implications and the mechanisms underlying hepatic iron overload remain unclear. Herein,...
- The Calreticulin-Binding Sequence of Thrombospondin 1 Regulates Collagen Expression and Organization During Tissue Remodeling
[作者:Sweetwyne, MT; Pallero, MA; Lu, AL; Graharn, LVD; Murphy-Ullrich, JE,期刊:American Journal of Pathology, 页码:1710-1724 , 文章类型: Article,,卷期:2010年177-4]
- Amino acids 17-35 of the thrombospondin1 (TSP1) N-terminal domain (NTD) bind cell surface calreticulin to signal focal adhesion disassembly, cell migration, and anoikis resistance in vitro. However, the in vivo relevance...
- A beta Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model
[作者:Hurtado, DE; Molina-Porcel, L; Iba, M; Aboagye, AK; Paul, SM; Trojanowski, JQ; Lee, VMY,期刊:American Journal of Pathology, 页码:1977-1988 , 文章类型: Article,,卷期:2010年177-4]
- Senile plaques formed by beta-amyloid peptides (A beta) and neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau, a microtubule-associated protein, are the hallmark lesions of Alzheimer's disease (AD) in addi...
- Evaluation of Bone Marrow- and Brain-Derived Neural Stem Cells in Therapy of Central Nervous System Autoimmunity
[作者:Yang, JX; Yan, YP; Ciric, B; Yu, S; Guan, YT; Xu, H; Rostami, A; Zhang, GX,期刊:American Journal of Pathology, 页码:1989-2001 , 文章类型: Article,,卷期:2010年177-4]
- Adult subventricular zone (SVZ)-derived neural stem cells (NSCs) have therapeutic effects in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. However, SVZ precursor cells as a source of N...
- Lin(-) Cells Mediate Tissue Repair by Regulating MCP-1/CCL-2
[作者:Schatteman, GC; Awad, O; Nau, E; Wang, CL; Jiao, CH; Tomanek, RJ; Dunnwald, M,期刊:American Journal of Pathology, 页码:2002-2010 , 文章类型: Article,,卷期:2010年177-4]
- Exogenous bone marrow-derived cells (BMDCs) are promising therapeutic agents for the treatment of tissue ischemia and traumatic injury. However, until we identify the molecular mechanisms that underlie their actions, the...
- Stem Cells Derived from Human Amniotic Fluid Contribute to Acute Kidney Injury Recovery
[作者:Hauser, PV; De Fazio, R; Bruno, S; Sdei, S; Grange, C; Bussolati, B; Benedetto, C; Camussi, G,期刊:American Journal of Pathology, 页码:2011-2021 , 文章类型: Article,,卷期:2010年177-4]
- Stem cells isolated from human amniotic fluid are gaining attention with regard to their therapeutic potential. In this work, we investigated whether these cells contribute to tubular regeneration after experimental acut...
- Increase in Viral Load, Viral Integration, and Gain of Telomerase Genes during Uterine Cervical Carcinogenesis can be Simultaneously Assessed by the HPV 16/18 MLPA-Assay
[作者:Theelen, W; Speel, EJM; Herfs, M; Reijans, M; Simons, G; Meulemans, EV; Baldewijns, MM; Ramaekers, FCS; Somja, J; Delvenne, P; Hopman, AHN,期刊:American Journal of Pathology, 页码:2022-2033 , 文章类型: Article,,卷期:2010年177-4]
- Oncogenic human papillomavirus (HPV) infection is the most important risk factor in cervical carcinogenesis cases; high viral loads, viral integration into the host genome, and gain of the telomerase-related genes, TERT ...
- Targeting DNA Replication before it Starts Cdc7 as a Therapeutic Target in p53-Mutant Breast Cancers
[作者:Rodriguez-Acebes, S; Proctor, I; Loddo, M; Wollenschlaeger, A; Rashid, M; Falzon, M; Prevost, AT; Sainsbury, R; Stoeber, K; Williams, GH,期刊:American Journal of Pathology, 页码:2034-2045 , 文章类型: Article,,卷期:2010年177-4]
- Treatment options for triple-receptor negative (ER-/-PR/Her2-) and Her2-overexpressing (ER-/PR-/Her2+) breast cancers with acquired or de novo resistance are limited, and metastatic disease remains incurable. Targeting o...
- Loss of Inducible Nitric Oxide Synthase Expression in the Mouse Renal Cell Carcinoma Cell Line RENCA Is Mediated by MicroRNA miR-146a
[作者:Perske, C; Lahatt, N; Levin, SS; Bitterman, H; Hemmerlein, B; Rahat, MA,期刊:American Journal of Pathology, 页码:2046-2054 , 文章类型: Article,,卷期:2010年177-4]
- Tumor-associated macrophages can potentially kill tumor cells via the high concentrations of nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS); however, tumor-associated macrophages actually support tu...
- Impaired Wnt Signaling in Embryonal Rhabdomyosarcoma Cells from p53/c-fos Double Mutant Mice
[作者:Singh, S; Vinson, C; Gurley, CM; Nolen, GT; Beggs, ML; Nagarajan, R; Wagner, EF; Parham, DM; Peterson, CA,期刊:American Journal of Pathology, 页码:2055-2066 , 文章类型: Article,,卷期:2010年177-4]
- Rhabdomyosarcoma is a primitive neoplasm with a poorly understood etiology that exhibits features of fetal skeletal muscle. It represents the most frequent malignant soft tissue sarcoma affecting the pediatric population...
- Site-Dependent E-Cadherin Cleavage and Nuclear Translocation in a Metastatic Colorectal Cancer Model
[作者:Cespedes, MV; Larriba, MJ; Pavon, MA; Alamo, P; Casanova, I; Parreno, M; Feliu, A; Sancho, FJ; Munoz, A; Mangues, R,期刊:American Journal of Pathology, 页码:2067-2079 , 文章类型: Article,,卷期:2010年177-4]
- Metastases are frequently found during colorectal cancer diagnoses and are the main determinants of clinical outcome. The lack of reliable models of metastases has precluded their mechanistic understanding and our capaci...
- Constant p53 Pathway Inactivation in a Large Series of Soft Tissue Sarcomas with Complex Genetics
[作者:Perot, G; Chibon, F; Montero, A; Lagarde, P; de The, H; Terrier, P; Guillou, L; Ranchere, D; Coindre, JM; Aurias, A,期刊:American Journal of Pathology, 页码:2080-2090 , 文章类型: Article,,卷期:2010年177-4]
- Alterations of the p53 pathway are among the most frequent aberrations observed in human cancers. We have performed an exhaustive analysis of TP53,p14, p15, and p16 status in a large series of 143 soft tissue sarcomas, r...
- Resveratrol Prevents Light-Induced Retinal Degeneration via Suppressing Activator Protein-1 Activation
[作者:Kubota, S; Kurihara, T; Ebinuma, M; Kubota, M; Yuki, K; Sasaki, M; Noda, K; Ozawa, Y; Oike, Y; Ishida, S; Tsubota, K,期刊:American Journal of Pathology, 页码:1725-1731 , 文章类型: Article,,卷期:2010年177-4]
- Light damage to the retina accelerates retinal degeneration in human diseases and rodent models. Recently, the polyphenolic phytoalexin resveratrol has been shown to exert various bioactivities in addition to its classic...
- The Role of Vascular Endothelial Growth Factor-Induced Activation of NADPH Oxidase in Choroidal Endothelial Cells and Choroidal Neovascularization
[作者:Monaghan-Benson, E; Hartmann, J; Vendrov, AE; Budd, S; Byfield, G; Parker, A; Ahmad, F; Huang, W; Runge, M; Burridge, K; Madamanchi, N; Hartnett, ME,期刊:American Journal of Pathology, 页码:2091-2102 , 文章类型: Article,,卷期:2010年177-4]
- Rac1, a subunit of NADPH oxidase, plays an important role in directed endothelial cell motility. We reported previously that Rac1 activation was necessary for choroidal endothelial cell migration across the retinal pigme...
- Genetic Ablation of TWEAK Augments Regeneration and Post-Injury Growth of Skeletal Muscle in Mice
[作者:Mittel, A; Bhatnagar, S; Kumar, A; Paul, PK; Kuang, S; Kumar, A,期刊:American Journal of Pathology, 页码:1732-1742 , 文章类型: Article,,卷期:2010年177-4]
- Impairment in the regeneration process is a critical determinant for skeletal muscle wasting in chronic diseases and degenerative muscle disorders. Inflammatory cytokines are known to cause significant muscle wasting, ho...
- Transforming Growth Factor-beta 1 Induces Smad3-Dependent beta(1) Integrin Gene Expression in Epithelial-to-Mesenchymal Transition during Chronic Tubulointerstitial Fibrosis
[作者:Yeh, YC; Wei, WC; Wang, YK; Lin, SC; Sung, JM; Tang, MJ,期刊:American Journal of Pathology, 页码:1743-1754 , 文章类型: Article,,卷期:2010年177-4]
- Transforming growth factor-beta 1 (TGF-beta 1)-induced epithelial-to-mesenchymal transition (EMT) contributes to the pathophysiological development of kidney fibrosis. Although it was reported that TGF-beta 1 enhances be...
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