- Characterization of Erg K+ Channels in alpha- and beta-Cells of Mouse and Human Islets
[作者:Hardy, AB; Fox, JEM; Giglou, PR; Wijesekara, N; Bhattacharjee, A; Sultan, S; Gyulkhandanyan, AV; Gaisano, HY; MacDonald, PE; Wheeler, MB,期刊:Journal of Biological Chemistry, 页码:30441-30452 , 文章类型: Article,,卷期:2009年284-44]
- Voltage-gated eag-related gene (Erg) K+ channels regulate the electrical activity of many cell types. Data regarding Erg channel expression and function in electrically excitable glucagon and insulin producing cells of t...
- Human BAMBI Cooperates with Smad7 to Inhibit Transforming Growth Factor-beta Signaling
[作者:Yan, XH; Lin, ZH; Chen, F; Zhao, XG; Chen, H; Ning, YH; Chen, YG,期刊:Journal of Biological Chemistry, 页码:30097-30104 , 文章类型: Article,,卷期:2009年284-44]
- Transforming growth factor beta (TGF-beta) and related growth factors are essential regulators of embryogenesis and tissue homeostasis. The signaling pathways mediated by their receptors and Smad proteins are precisely m...
- Activation of the Liver X Receptor Prevents Lipopolysaccharide-induced Lung Injury
[作者:Gong, HBA; He, JH; Lee, JH; Mallick, E; Gao, X; Li, S; Homanics, GE; Xie, W,期刊:Journal of Biological Chemistry, 页码:30113-30121 , 文章类型: Article,,卷期:2009年284-44]
- The liver X receptors (LXRs) have been known as sterol sensors that impact cholesterol and lipid homeostasis, as well as inflammation. Although the hepatic functions of LXRs are well documented, whether and how LXRs play...
- Diversity and Developmental Expression of L-type Calcium Channel beta 2 Proteins and Their Influence on Calcium Current in Murine Heart
[作者:Link, S; Meissner, M; Held, B; Beck, A; Weissgerber, P; Freichel, M; Flockerzi, V,期刊:Journal of Biological Chemistry, 页码:30129-30137 , 文章类型: Article,,卷期:2009年284-44]
- By now, little is known on L-type calcium channel (LTCC) subunits expressed in mouse heart. We show that CaV beta 2 proteins are the major CaV beta components of the LTCC in embryonic and adult mouse heart, but that in e...
- SIP30 Is Regulated by ERK in Peripheral Nerve Injury-induced Neuropathic Pain
[作者:Peng, GD; Han, M; Du, YM; Lin, AN; Yu, L; Zhang, YQ; Jing, NH,期刊:Journal of Biological Chemistry, 页码:30138-30147 , 文章类型: Article,,卷期:2009年284-44]
- ERK plays an important role in chronic neuropathic pain. However, the underlying mechanism is largely unknown. Here we show that in chronic constriction injury-treated rat spinal cords, up-regulation of SIP30 (SNAP25-int...
- Analysis of PTEN Complex Assembly and Identification of Heterogeneous Nuclear Ribonucleoprotein C as a Component of the PTEN-associated Complex
[作者:Mosessian, S; Avliyakulov, NK; Mulholland, DJ; Boontheung, P; Loo, JA; Wu, H,期刊:Journal of Biological Chemistry, 页码:30159-30166 , 文章类型: Article,,卷期:2009年284-44]
- PTEN (phosphatase and tensin homolog deleted on chromosome 10) is well characterized for its role in antagonizing the phosphoinositide 3-kinase pathway. Previous studies using size-exclusion chromatography demonstrated P...
- Insulin-stimulated Phosphorylation of the Rab GTPase-activating Protein TBC1D1 Regulates GLUT4 Translocation
[作者:Peck, GR; Chavez, JA; Roach, WG; Budnik, BA; Lane, WS; Karlsson, HKR; Zierath, JR; Lienhard, GE,期刊:Journal of Biological Chemistry, 页码:30016-30023 , 文章类型: Article,,卷期:2009年284-44]
- Insulin stimulates the translocation of the glucose transporter GLUT4 from intracellular locations to the plasma membrane in adipose and muscle cells. Prior studies have shown that Akt phosphorylation of the Rab GTPase-a...
- Characterization of a Disease-associated Mutation Affecting a Putative Splicing Regulatory Element in Intron 6b of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene
[作者:Faa, V; Incani, F; Meloni, A; Corda, D; Masala, M; Baffico, AM; Seia, M; Cao, A; Rosatelli, MC,期刊:Journal of Biological Chemistry, 页码:30024-30031 , 文章类型: Article,,卷期:2009年284-44]
- Cystic fibrosis (CF) is a common recessive disorder caused by > 1600 mutations in the CF transmembrane conductance regulator (CFTR) gene. About 13% of CFTR mutations are classified as "splicing mutations," but for almost...
- Mcl-1 Degradation during Hepatocyte Lipoapoptosis
[作者:Masuoka, HC; Mott, J; Bronk, SF; Werneburg, NW; Akazawa, Y; Kaufmann, SH; Gores, GJ,期刊:Journal of Biological Chemistry, 页码:30039-30048 , 文章类型: Article,,卷期:2009年284-44]
- The mechanisms of free fatty acid-induced lipoapoptosis are incompletely understood. Here we demonstrate that Mcl-1, an anti-apoptotic member of the Bcl-2 family, was rapidly degraded in hepatocytes in response to palmit...
- Interferons Direct an Effective Innate Response to Legionella pneumophila Infection
[作者:Plumlee, CR; Lee, C; Beg, AA; Decker, T; Shuman, HA; Schindler, C,期刊:Journal of Biological Chemistry, 页码:30058-30066 , 文章类型: Article,,卷期:2009年284-44]
- Legionella pneumophila remains an important opportunistic pathogen of human macrophages. Its more limited ability to replicate in murine macrophages has been attributed to redundant innate sensor systems that detect and ...
- Dual Role of DNA in Regulating ATP Hydrolysis by the SopA Partition Protein
[作者:Ah-Seng, Y; Lopez, F; Pasta, F; Lane, D; Bouet, JY,期刊:Journal of Biological Chemistry, 页码:30067-30075 , 文章类型: Article,,卷期:2009年284-44]
- In bacteria, mitotic stability of plasmids and many chromosomes depends on replicon-specific systems, which comprise a centromere, a centromere-binding protein and an ATPase. Dynamic self-assembly of the ATPase appears t...
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