- Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations
[作者:Malik, I; Turk, J; Mancuso, DJ; Montier, L; Wohltmann, M; Wozniak, DF; Schmidt, RE; Gross, RW; Kotzbauerg, PT,期刊:American Journal of Pathology, 页码:406-416 , 文章类型: Article,,卷期:2008年172-2]
- Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain ...
- Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1
[作者:Gallagher, AR; Esquivel, EL; Briere, TS; Tian, X; Mitobe, M; Menezes, LF; Markowitz, GS; Jain, D; Onuchic, LF; Somlo, S,期刊:American Journal of Pathology, 页码:417-429 , 文章类型: Article,,卷期:2008年172-2]
- Autosomal recessive polycystic kidney disease is a hereditary fibrocystic disease that involves the kidneys and the biliary tract. Mutations in the PKHD1 gene are responsible for typical forms of autosomal recessive poly...
- Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease
[作者:Suva, LJ; Hartman, E; Dilley, JD; Russell, S; Akel, NS; Skinner, RA; Hogue, WR; Budde, U; Varughese, KI; Kanaji, T; Ware, J,期刊:American Journal of Pathology, 页码:430-439 , 文章类型: Article,,卷期:2008年172-2]
- The platelet glycoprotein Ib-IX receptor binds surface-bound von Willebrand factor and supports platelet adhesion to damaged vascular surfaces. A limited number of mutations within the glycoprotein Ib-IX complex have bee...
- Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis
[作者:Henderson, NC; Mackinnon, AC; Farnworth, SL; Kipari, T; Haslett, C; Iredale, JP; Liu, FT; Hughes, J; Sethi, T,期刊:American Journal of Pathology, 页码:288-298 , 文章类型: Article,,卷期:2008年172-2]
- Macrophages have been proposed as a key cell type in the pathogenesis of renal fibrosis; however, the mechanism by which macrophages drive fibrosis is still unclear. We show that expression of galectin-3, a beta-galactos...
- Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria
[作者:Li, YJ; Kang, YS; Dai, CS; Kiss, LP; Wen, XY; Liu, YH,期刊:American Journal of Pathology, 页码:299-308 , 文章类型: Article,,卷期:2008年172-2]
- Podocyte dysfunction plays an essential role in the pathogenesis of proteinuria and glomerulosclerosis. However, the mechanism underlying podocyte dysfunction in many common forms of chronic kidney diseases remains poorl...
- Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation
[作者:Borensztajn, K; Stiekema, J; Nijmeijer, S; Reitsmalf, PH; Peppelenbosch, MP; Spek, CA,期刊:American Journal of Pathology, 页码:309-320 , 文章类型: Article,,卷期:2008年172-2]
- Coagulation proteases have been suggested to play a role in the pathogenesis of tissue remodeling and fibrosis. We therefore assessed the proinflammatory and fibroproliferative effects of coagulation protease factor (F)X...
- Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney disease
[作者:Alvaro, D; Onori, P; Alpini, G; Franchitto, A; Jefferson, DM; Torrice, A; Cardinale, V; Stefanelli, F; Mancino, MG; Strazzabosco, M; Angelico, M; Attili, A; Gaudiot, E,期刊:American Journal of Pathology, 页码:321-332 , 文章类型: Article,,卷期:2008年172-2]
- We evaluated the morphological and functional features of hepatic cyst epithelium in adult autosomal dominant polycystic kidney disease (ADPKD). in six ADPKD patients, we investigated the morphology of cyst epithelium ap...
- Role of a serotonin precursor in development of gut microvilli
[作者:Nakamura, K; Sato, T; Ohashi, A; Tsurui, H; Hasegawa, H,期刊:American Journal of Pathology, 页码:333-344 , 文章类型: Article,,卷期:2008年172-2]
- Monoamines exert diverse functions in various cells in peripheral organs as well as in the central nervous system. 5-Hydroxy-L-tryptophan (5-HTP) has been simply regarded as a precursor of serotonin, and it is believed t...
- Regulation of cripto-1 signaling and biological activity by caveolin-1 in mammary epithelial cells
[作者:Bianco, C; Strizzi, L; Mancino, M; Watanabe, K; Gonzales, M; Hamada, S; Raafat, A; Sahlah, L; Chang, C; Sotgia, F; Normanno, N; Lisanti, M; Salomon, DS,期刊:American Journal of Pathology, 页码:345-357 , 文章类型: Article,,卷期:2008年172-2]
- Human and mouse Cripto-1 (CR-1/Cr-1) proteins play an important role in mammary gland development and tumorigenesis. in this study, we examined the relationship between Cripto-1 and caveolin-1 (Cav-1), a membrane protein...
- Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors
[作者:Kuwai, T; Nakamura, T; Kim, SJ; Sasaki, T; Kitadai, Y; Langley, RR; Fan, D; Hamilton, SR; Fidler, IJ,期刊:American Journal of Pathology, 页码:358-366 , 文章类型: Article,,卷期:2008年172-2]
- The design of targeted therapy, particularly patient-specific targeted therapy, requires knowledge of the presence and intratumoral distribution of tyrosine kinase receptors. To determine whether the expression of such r...
- Short-term heat exposure inhibits inflammation by abrogating recruitment of and nuclear factor-kappa B activation in neutrophils exposed to chemotactic cytokines
[作者:Choi, M; Salanova, B; Rolle, S; Wellner, M; Schneider, W; Luft, FC; Kettritz, R,期刊:American Journal of Pathology, 页码:367-377 , 文章类型: Article,,卷期:2008年172-2]
- Cytokines, such as granulocyte macrophage-colony stimulating factor (GM-CSF) and interleukin (IL)-8 attract neutrophils into inflammatory sites. During emigration from the blood neutrophils interact with extracellular ma...
- Adoptively transferred dendritic cells restore primary cell-mediated inflammatory competence to acutely malnourished weanling mice
[作者:Hillyer, L; Whitley, C; Olver, A; Webster, M; Steevels, T; Woodward, B,期刊:American Journal of Pathology, 页码:378-385 , 文章类型: Article,,卷期:2008年172-2]
- Immune depression associated with prepubescent malnutrition underlies a staggering burden of infection-related morbidity. This investigation centered on dendritic cells as potentially decisive in this phenomenon. C57BL/6...
- Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function
[作者:Farnworth, SL; Henderson, NC; MacKinnon, AC; Atkinson, KM; Wilkinson, T; Dhaliwal, K; Hayashi, K; Simpson, AJ; Rossi, AG; Haslett, C; Sethi, T,期刊:American Journal of Pathology, 页码:395-405 , 文章类型: Article,,卷期:2008年172-2]
- The Gram-positive Streptococcus pneumoniae is the leading cause of community-acquired pneumonia worldwide, resulting in high mortality. Our in vivo studies show that galectin-3(-/-) mice develop more severe pneumonia aft...
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