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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   NMD: RNA biology meets human genetic medicine [作者：Bhuvanagiri, M; Schlitter, AM; Hentze, MW; Kulozik, AE,期刊：Biochemical Journal, 页码：365-377 , 文章类型： Review，,卷期：2010年430-Part 3] NMD (nonsense-mediated mRNA decay) belongs to the best-studied mRNA surveillance systems of the cell, limiting the synthesis of truncated and potentially harmful proteins on the one hand and playing an initially unexpect... Functional diversity of the hnRNPs: past, present and perspectives [作者：Han, SP; Tang, YH; Smith, R,期刊：Biochemical Journal, 页码：379-392 , 文章类型： Review，,卷期：2010年430-Part 3] The hnRNPs (heterogeneous nuclear ribonucleoproteins) are RNA-binding proteins with important roles in multiple aspects of nucleic acid metabolism, including the packaging of nascent transcripts, alternative splicing and... 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization [作者：Nichols, RJ; Dzamko, N; Morrice, NA; Campbell, DG; Deak, M; Ordureau, A; Macartney, T; Tong, YR; Shen, J; Prescott, AR; Alessi, DR,期刊：Biochemical Journal, 页码：393-404 , 文章类型： Article，,卷期：2010年430-Part 3] LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of Parkinson's disease patients, but still little is understood about how it is regulated or functions. In the present study we have demonst... Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization [作者：Dzamko, N; Deak, M; Hentati, F; Reith, AD; Prescott, AR; Alessi, DR; Nichols, RJ,期刊：Biochemical Journal, 页码：405-413 , 文章类型： Article，,卷期：2010年430-Part 3] LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of Parkinson's disease patients. Since a common mutation that replaces Gly(2019) with a serine residue enhances kinase catalytic activity, s... Fluorescent probe partitioning in giant unilamellar vesicles of 'lipid raft' mixtures [作者：Juhasz, J; Davis, JH; Sharom, FJ,期刊：Biochemical Journal, 页码：415-423 , 文章类型： Article，,卷期：2010年430-Part 3] Direct visualization of raft-like l(o) (liquid-ordered) domains in model systems and cells using microscopic techniques requires fluorescence probes with known partitioning preference for one of the phases present. Howev... Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain [作者：Lee, CC; Jia, Y; Li, NX; Sun, XY; Ng, K; Ambing, E; Gao, MY; Hua, S; Chen, C; Kim, S; Michellys, PY; Lesley, SA; Harris, JL; Spraggon, G,期刊：Biochemical Journal, 页码：425-437 , 文章类型： Article，,卷期：2010年430-Part 3] ALK (anaplastic lymphoma kinase) is an RTK (receptor tyrosine kinase) of the IRK (insulin receptor kinase) superfamily, which share an YXXXYY autophosphorylation motif within their A-loops (activation loops). A common... p38(MAPK)/p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration [作者：Cardaci, S; Filomeni, G; Rotilio, G; Ciriolo, MR,期刊：Biochemical Journal, 页码：439-451 , 文章类型： Article，,卷期：2010年430-Part 3] BH4 (tetrahydrobiopterin) induces neuronal demise via production of ROS (reactive oxygen species). In the present study we investigated the mechanisms of its toxicity and the redox signalling events responsible for the a... Evidence for an interaction between Golli and STIM1 in store-operated calcium entry [作者：Walsh, CM; Doherty, MK; Tepikin, AV; Burgoyne, RD,期刊：Biochemical Journal, 页码：453-460 , 文章类型： Article，,卷期：2010年430-Part 3] SOCCs (store-operated Ca2+ channels) are highly selective ion channels that are activated upon release of Ca2+ from intracellular stores to regulate a multitude of diverse cellular functions. It was reported previously t... Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta 5-subunit [作者：Blackburn, C; Gigstad, KM; Hales, P; Garcia, K; Jones, M; Bruzzese, FJ; Barrett, C; Liu, JX; Soucy, TA; Sappal, DS; Bump, N; Olhava, EJ; Fleming, P; Dick, LR; Tsu, C; Sintchak, MD; Blank, JL,期刊：Biochemical Journal, 页码：461-476 , 文章类型： Article，,卷期：2010年430-Part 3] The mammalian 26S proteasome is a 2500 kDa multi-catalytic complex involved in intracellular protein degradation. We describe the synthesis and properties of a novel series of non-covalent di-peptide inhibitors of the pr... The hydrophobic core region governs mutant prion protein aggregation and intracellular retention [作者：Biasini, E; Tapella, L; Restelli, E; Pozzoli, M; Massignan, T; Chiesa, R,期刊：Biochemical Journal, 页码：477-486 , 文章类型： Article，,卷期：2010年430-Part 3] Approx. 15% of human prion diseases have a pattern of autosomal dominant inheritance, and are linked to mutations in the gene encoding PrP (prion protein), a GPI (glycosylphosphatidylinositol)-anchored protein whose func... Determinants of activity in glutaredoxins: an in vitro evolved Grx1-like variant of Escherichia coli Grx3 [作者：Elgan, TH; Planson, AG; Beckwith, J; Guntert, P; Berndt, KD,期刊：Biochemical Journal, 页码：487-495 , 文章类型： Article，,卷期：2010年430-Part 3] The Escherichia coil glutaredox ins 1 and 3 (Grx 1 and Grx3) are structurally similar (37 % sequence identity), yet have different activities in vivo. Unlike Grx3, Grx 1 efficiently reduces protein disulfides in proteins... Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane [作者：Zhang, YG; Hayes, JD,期刊：Biochemical Journal, 页码：497-510 , 文章类型： Article，,卷期：2010年430-Part 3] Nrf1 [NF-E2 (nuclear factor-erythroid 2)-related factor 1] is a CNC (cap'n'collar) bZIP (basic-region leucine zipper) transcription factor that is tethered to ER (endoplasmic reticulum) and nuclear envelope membranes thr... Zn(II) ions co-secreted with insulin suppress inherent amyloidogenic properties of monomeric insulin [作者：Noormagi, A; Gavrilova, J; Smirnova, J; Tougu, V; Palumaa, P,期刊：Biochemical Journal, 页码：511-518 , 文章类型： Article，,卷期：2010年430-Part 3] Insulin, a 51-residue peptide hormone, is an intrinsically amyloidogenic peptide, forming amyloid fibrils in vitro. In the secretory granules, insulin is densely packed together with Zn(II) into crystals of Zn(2)Insulin(... Extensive sphingolipid depletion does not affect lipid raft integrity or lipid raft localization and efflux function of the ABC transporter MRP1 [作者：Klappe, K; Dijkhuis, AJ; Hummel, I; van Dam, A; Ivanova, PT; Milne, SB; Myers, DS; Brown, HA; Permentier, H; Kok, JW,期刊：Biochemical Journal, 页码：519-529 , 文章类型： Article，,卷期：2010年430-Part 3] We show that highly efficient depletion of sphingolipids in two different cell lines does not abrogate the ability to isolate Lubrol-based DRMs (detergent-resistant membranes) or detergent-free lipid rafts from these cel... Calpain is involved in C-terminal truncation of human aggrecan [作者：Struglics, A; Hansson, M,期刊：Biochemical Journal, 页码：531-538 , 文章类型： Article，,卷期：2010年430-Part 3] Mature aggrecan is generally C-terminally truncated at several sites in the CS (chondroitin sulfate) region. Aggrecanases and MMPs (matrix metalloproteinases) have been suggested to be responsible for this digestion. To ... Intermolecular phosphotransfer is crucial for efficient catalytic activity of nucleoside diphosphate kinase [作者：Dar, HH; Chakraborti, PK,期刊：Biochemical Journal, 页码：539-549 , 文章类型： Article，,卷期：2010年430-Part 3] NDK (nucleoside diphosphate kinase) is primarily involved in maintaining cellular nucleotide pools in both prokaryotes and eukaryotes. We cloned ndk from Salmonella typhimurium and expressed it in Escherichia coli as a h...