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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共22条记录   The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals [作者：Thierbach, R; Drewes, G; Fusser, M; Voigt, A; Kuhlow, D; Blume, U; Schulz, TJ; Reiche, C; Glatt, H; Epe, B; Steinberg, P; Ristow, M,期刊：Biochemical Journal, 页码：165-172 , 文章类型： Article，,卷期：2010年432-Part 1] DNA-repair mechanisms enable cells to maintain their genetic information by protecting it from mutations that may cause malignant growth. Recent evidence suggests that specific DNA-repair enzymes contain ISCs (iron-sulfu... Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptor [作者：Arfilli, V; Carnicelli, D; Rocchi, L; Ricci, F; Pagliaro, P; Tazzari, PL; Brigotti, M,期刊：Biochemical Journal, 页码：173-180 , 文章类型： Article，,卷期：2010年432-Part 1] The main cause of acute renal failure in children is HUS (haemolytic uraemic syndrome), a consequence of intestinal infections with Escherichia coli strains producing Six (Shiga toxins). Stx released in the gut by the no... Functional domains of yeast hexokinase 2 [作者：Pelaez, R; Herrero, P; Moreno, F,期刊：Biochemical Journal, 页码：181-190 , 文章类型： Article，,卷期：2010年432-Part 1] Hkx2 (hexokinase 2) from Saccharomyces cerevisiae was one of the first metabolic enzymes described as a multifunctional protein. Hxk2 has a double subcellular localization: it functions as a glycolytic enzyme in the cyto... Akt inhibitors reduce glucose uptake independently of their effects on Akt [作者：Tan, SX; Ng, Y; James, DE,期刊：Biochemical Journal, 页码：191-197 , 文章类型： Article，,卷期：2010年432-Part 1] The protein kinase Akt is involved in various cellular processes, including cell proliferation, growth and metabolism. Hyperactivation of Akt is commonly observed in human tumours and so this pathway has been the focus o... MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells [作者：Jiang, L; Liu, XQ; Chen, ZJ; Jin, Y; Heidbreder, CE; Kolokythas, A; Wang, AX; Dai, Y; Zhou, XF,期刊：Biochemical Journal, 页码：199-205 , 文章类型： Article，,卷期：2010年432-Part 1] miR-7 (microRNA-7) has been characterized as a tumour suppressor in several human cancers. It targets a number of proto-oncogenes that contribute to cell proliferation and survival. However, the mechanism(s) by which miR... Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C [作者：Bird, RJ; Baillie, GS; Yarwood, SJ,期刊：Biochemical Journal, 页码：207-216 , 文章类型： Article，,卷期：2010年432-Part 1] We have previously identified the PKC (protein kinase C)anchoring protein RACK1 (receptor for activated C-kinase 1), as a specific binding partner for the cAMP-specific phosphodiesterase PDE4D5, suggesting a potential si... Functional dissection of the N-terminal degron of human thymidylate synthase [作者：Melo, SP; Yoshida, A; Berger, FG,期刊：Biochemical Journal, 页码：217-226 , 文章类型： Article，,卷期：2010年432-Part 1] Human thymidylate synthase (hTS; EC 2.1.1.45) is one of a small group of proteasomal substrates whose intracellular degradation occurs in a ubiquitin-independent manner. Previous studies have shown that proteolytic break... Human OGA binds substrates in a conserved peptide recognition groove [作者：Schimpl, M; Schuttelkopf, AW; Borodkin, VS; van Aalten, DMF,期刊：Biochemical Journal, 页码：1-7 , 文章类型： Article，,卷期：2010年432-Part 1] Modification of cellular proteins with O-GlcNAc (O-linked N-acetylglucosamine) competes with protein phosphorylation and regulates a plethora of cellular processes. O-GlcNAcylation is orchestrated by two opposing enzymes... Prevention of diabetic nephropathy in Ins2(+/-AkitaJ) mice by the mitochondria-targeted therapy MitoQ [作者：Chacko, BK; Reily, C; Srivastava, A; Johnson, MS; Ye, YZ; Ulasova, E; Agarwal, A; Zinn, KR; Murphy, MP; Kalyanaraman, B; Darley-Usmar, V,期刊：Biochemical Journal, 页码：9-19 , 文章类型： Article，,卷期：2010年432-Part 1] Mitochondrial production of ROS (reactive oxygen species) is thought to be associated with the cellular damage resulting from chronic exposure to high glucose in long-term diabetic patients. We hypothesized that a mitoch... High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules [作者：Andrews, PD; Becroft, M; Aspegren, A; Gilmour, J; James, MJ; Mcrae, S; Kime, R; Allcock, RW; Abraham, A; Jiang, Z; Strehl, R; Mountford, JC; Milligan, G; Houslay, MD; Adams, DR; Frearson, JA,期刊：Biochemical Journal, 页码：21-33 , 文章类型： Article，,卷期：2010年432-Part 1] The propensity of human embryonic stem cells to die upon enzymatic disaggregation or low-density plating is an obstacle to their isolation and routine use in drug discovery and basic research. Equally, the very low rate ... Lysophosphatidylcholines activate G2A inducing G(alpha i-1)-/G(alpha q/11)- Ca2+ flux, G(beta gamma)-Hck activation and clathrin/beta-arrestin-1/GRK6 recruitment in PMNs [作者：Khan, SY; McLaughlin, NJD; Kelher, MR; Eckels, P; Gamboni-Robertson, F; Banerjee, A; Silliman, CC,期刊：Biochemical Journal, 页码：35-45 , 文章类型： Article，,卷期：2010年432-Part 1] Lyso-PCs (lysophosphatidylcholines) are a mixture of lipids that accumulate during storage of cellular blood components, have been implicated in TRALI (transfusion-related acute lung injury) and directly affect the physi... Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development [作者：Watanabe, Y; Takeuchi, K; Onaga, SH; Sato, M; Tsujita, M; Abe, M; Natsume, R; Li, MQ; Furuichi, T; Saeki, M; Izumikawa, T; Hasegawa, A; Yokoyama, M; Ikegawa, S; Sakimura, K; Amizuka, N; Kitagawa, H; Igarashi, M,期刊：Biochemical Journal, 页码：47-55 , 文章类型： Article，,卷期：2010年432-Part 1] CS (chondroitin sulfate) is a glycosaminoglycan species that is widely distributed in the extracellular matrix. To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acet... The role of vicinal tyrosine residues in the function of Haemophilus influenzae ferric-binding protein A [作者：Khambati, HK; Moraes, TF; Singh, J; Shouldice, SR; Yu, RH; Schryvers, AB,期刊：Biochemical Journal, 页码：57-64 , 文章类型： Article，,卷期：2010年432-Part 1] The periplasmic FbpA (ferric-binding protein A) from Haemophilus influenzae plays a critical role in acquiring iron from host transferrin, shuttling iron from the outer-membrane receptor complex to the inner-membrane tra... Lipin proteins form homo- and hetero-oligomers [作者：Liu, GH; Qu, J; Carmack, AE; Kim, HB; Chen, C; Ren, HM; Morris, AJ; Finck, BN; Harris, TE,期刊：Biochemical Journal, 页码：65-76 , 文章类型： Article，,卷期：2010年432-Part 1] Lipin family members (lipin 1, 2 and 3) are bi-functional proteins that dephosphorylate PA (phosphatidic acid) to produce DAG (diacylglycerol) and act in the nucleus to regulate gene expression. Although other components... Regulation of the tumour suppressor Fbw7 alpha by PKC-dependent phosphorylation and cancer-associated mutations [作者：Durgan, J; Parker, PJ,期刊：Biochemical Journal, 页码：77-87 , 文章类型： Article，,卷期：2010年432-Part 1] Fbw7 (F-box WD40 protein 7) is a major tumour suppressor, which mediates the degradation of several potent oncogenes. PKC (protein kinase C) comprises a serine/threonine kinase family that can promote transformation when... Site-specific modification of calmodulin Ca2+ affinity tunes the skeletal muscle ryanodine receptor activation profile [作者：Jiang, J; Zhou, YB; Zou, J; Chen, YY; Patel, P; Yang, JJ; Balog, EM,期刊：Biochemical Journal, 页码：89-99 , 文章类型： Article，,卷期：2010年432-Part 1] The skeletal muscle isoform of the ryanodine receptor Ca2+-release channel (RyR1) is regulated by Ca2+ and CaM (calmodulin). CaM shifts the biphasic Ca2+-dependence of RyR1 activation leftward, effectively increasing cha...