- D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate
[作者:El Sayed, SM; Abou El-Magd, RM; Shishido, Y; Chung, SP; Sakai, T; Watanabe, H; Kagami, S; Fukui, K,期刊:Cancer gene therapy, 页码:1-18 , 文章类型: Article,,卷期:2012年19-1]
- Glioma tumors are refractory to conventional treatment. Glioblastoma multiforme is the most aggressive type of primary brain tumors in humans. In this study, we introduce oxidative stress-energy depletion (OSED) therapy ...
- Fibroblast growth factor and ornithine decarboxylase 5 ' UTRs enable preferential expression in human prostate cancer cells and in prostate tumors of PTEN(-/-) transgenic mice
[作者:Moussavi, M; Moshgabadi, N; Fazli, L; Leblanc, E; Zhang, K; Jia, W; Rennie, PS,期刊:Cancer gene therapy, 页码:19-29 , 文章类型: Article,,卷期:2012年19-1]
- In this study, we have taken advantage of over-expression of eukaryotic translation initiation factor 4E (eIF4E) in prostate cancer cells to design a viral-based targeting system of prostate cancer. Three different lengt...
- Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function
[作者:Morse, MA; Hobeika, A; Serra, D; Aird, K; McKinney, M; Aldrich, A; Clay, T; Mourich, D; Lyerly, HK; Iversen, PL; Devi, GR,期刊:Cancer gene therapy, 页码:30-37 , 文章类型: Article,,卷期:2012年19-1]
- CD4+CD25+regulatory T cells (T(reg)) impair anti-tumor and anti-viral immunity. As there are higher T(reg) levels in cancer patients compared with healthy individuals, there is considerable interest in eliminating them o...
- Molecular network pathways and functional analysis of tumor signatures associated with development of resistance to viral gene therapy
[作者:Song, TJ; Haddad, D; Adusumilli, P; Kim, T; Stiles, B; Hezel, M; Socci, ND; Gonen, M; Fong, Y,期刊:Cancer gene therapy, 页码:38-48 , 文章类型: Article,,卷期:2012年19-1]
- Replication-competent attenuated herpes simplex viruses have proven effective in killing many cancer cell lines. However, determinants of resistance to oncolytic therapy are mostly unknown. We developed viral therapy-res...
- Gene-viro-therapy targeting liver cancer by a dual-regulated oncolytic adenoviral vector harboring IL-24 and TRAIL
[作者:Liu, X; Cao, X; Wei, R; Cai, Y; Li, H; Gui, J; Zhong, D; Liu, XY; Huang, K,期刊:Cancer gene therapy, 页码:49-57 , 文章类型: Article,,卷期:2012年19-1]
- Cancer-targeting gene-viro-therapy is a promising cancer therapeutic strategy that strengthens the antitumor effect of oncolytic viruses by expressing an inserted foreign antitumor gene. To achieve liver cancer targeting...
- The chicken chorioallantoic membrane tumor assay as model for qualitative testing of oncolytic adenoviruses
[作者:Durupt, F; Koppers-Lalic, D; Balme, B; Budel, L; Terrier, O; Lina, B; Thomas, L; Hoeben, RC; Rosa-Calatrava, M,期刊:Cancer gene therapy, 页码:58-68 , 文章类型: Article,,卷期:2012年19-1]
- Oncolytic adenoviruses are promising anticancer agents. To study and optimize their tumor-killing potency, genuine tumor models are required. Here we describe the use of the chicken chorioallantoic membrane (CAM) tumor m...
- CCL21 (SLC) improves tumor protection by a DNA vaccine in a Her2/neu mouse tumor model
[作者:Nguyen-Hoai, T; Baldenhofer, G; Ahmed, MSS; Pham-Duc, M; Vu, MD; Lipp, M; Dorken, B; Pezzutto, A; Westermann, J,期刊:Cancer gene therapy, 页码:69-76 , 文章类型: Article,,卷期:2012年19-1]
- Secondary lymphoid-tissue chemokine (SLC/CCL21) is a CC chemokine that is constitutively expressed in various lymphoid tissues and binds to chemokine receptor CCR7 on mature dendritic cells (DCs) and distinct T-and B-cel...
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