- cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane
[作者:Consonni, SV; Gloerich, M; Spanjaard, E; Bos, JL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3814-3819 , 文章类型: Article,,卷期:2012年109-10]
- Epac1 is a cAMP-regulated guanine nucleotide exchange factor for the small G protein Rap. Upon cAMP binding, Epac1 undergoes a conformational change that results in its release from autoinhibition. In addition, cAMP indu...
- Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXX Phi motif with the clathrin adaptors AP-1A and AP-1B
[作者:Carvajal-Gonzalez, JM; Gravotta, D; Mattera, R; Diaz, F; Bay, AP; Roman, AC; Schreiner, RP; Thuenauer, R; Bonifacino, JS; Rodriguez-Boulan, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3820-3825 , 文章类型: Article,,卷期:2012年109-10]
- The coxsackie and adenovirus receptor (CAR) plays key roles in epithelial barrier function at the tight junction, a localization guided in part by a tyrosine-based basolateral sorting signal, (318)YNQV(321). Sorting moti...
- Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
[作者:Diril, MK; Ratnacaram, CK; Padmakumar, VC; Du, TH; Wasser, M; Coppola, V; Tessarollo, L; Kaldis, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3826-3831 , 文章类型: Article,,卷期:2012年109-10]
- Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo func...
- A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation
[作者:Wontakal, SN; Guo, XY; Smith, C; MacCarthy, T; Bresnick, EH; Bergman, A; Snyder, MP; Weissman, SM; Zheng, DY; Skoultchi, AI,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3832-3837 , 文章类型: Article,,卷期:2012年109-10]
- Two mechanisms that play important roles in cell fate decisions are control of a "core transcriptional network" and repression of alternative transcriptional programs by antagonizing transcription factors. Whether these ...
- Full regeneration of the tribasal Polypterus fin
[作者:Cuervo, R; Hernandez-Martinez, R; Chimal-Monroy, J; Merchant-Larios, H; Covarrubias, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3838-3843 , 文章类型: Article,,卷期:2012年109-10]
- Full limb regeneration is a property that seems to be restricted to urodele amphibians. Here we found that Polypterus, the most basal living ray-finned fish, regenerates its pectoral lobed fins with a remarkable accuracy...
- Wing stridulation in a Jurassic katydid (Insecta, Orthoptera) produced low-pitched musical calls to attract females
[作者:Gu, JJ; Montealegre-Z, F; Robert, D; Engel, MS; Qiao, GX; Ren, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3868-3873 , 文章类型: Article,,卷期:2012年109-10]
- Behaviors are challenging to reconstruct for extinct species, particularly the nature and origins of acoustic communication. Here we unravel the song of Archaboilus musicus Gu, Engel and Ren sp. nov., a 165 million year ...
- Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
[作者:Lohr, JG; Stojanov, P; Lawrence, MS; Auclair, D; Chapuy, B; Sougnez, C; Cruz-Gordillo, P; Knoechel, B; Asmann, YW; Slager, SL; Novak, AJ; Dogan, A; Ansell, SM; Link, BK; Zou, LH; Gould, J; Saksena, G; Stransky, N; Rangel-Escareno, C; Fernandez-Lopez, JC; Hidalgo-Miranda, A; Melendez-Zajgla, J; Hernandez-Lemus, E; Celis, ASCY; Imaz-Rosshandler, I; Ojesina, AI; Jung, J; Pedamallu, CS; Lander, ES; Habermann, TM; Cerhan, JR; Shipp, MA; Getz, G; Golub, TR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3879-3884 , 文章类型: Article,,卷期:2012年109-10]
- To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed massively parallel whole-exome sequencing of 55 primary tumor samples from patients with DLBCL and matched normal tissue. We i...
- Rapid, efficient functional characterization and recovery of HIV-specific human CD8(+) T cells using microengraving
[作者:Varadarajan, N; Kwon, DS; Law, KM; Ogunniyi, AO; Anahtar, MN; Richter, JM; Walker, BD; Love, JC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3885-3890 , 文章类型: Article,,卷期:2012年109-10]
- The nature of certain clinical samples (tissue biopsies, fluids) or the subjects themselves (pediatric subjects, neonates) often constrain the number of cells available to evaluate the breadth of functional T-cell respon...
- CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells
[作者:Poppensieker, K; Otte, DM; Schurmann, B; Limmer, A; Dresing, P; Drews, E; Schumak, B; Klotz, L; Raasch, J; Mildner, A; Waisman, A; Scheu, S; Knolle, P; Forster, I; Prinz, M; Maier, W; Zimmer, A; Alferink, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3897-3902 , 文章类型: Article,,卷期:2012年109-10]
- Dendritic cells (DCs) are pivotal for the development of experimental autoimmune encephalomyelitis (EAE). However, the mechanisms by which they control disease remain to be determined. This study demonstrates that expres...
- Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development
[作者:Liu, XY; Jiang, WX; Dubois, RL; Yamamoto, K; Wolner, Z; Zha, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3903-3908 , 文章类型: Article,,卷期:2012年109-10]
- Nonhomologous end joining (NHEJ), a major pathway of DNA double-strand break (DSB) repair, is required during lymphocyte development to resolve the programmed DSBs generated during Variable, Diverse, and Joining [V(D)J] ...
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