- Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization
[作者:Milan, DJ; Kim, AM; Winterfield, JR; Jones, IL; Pfeufer, A; Sanna, S; Arking, DE; Amsterdam, AH; Sabeh, KM; Mably, JD; Rosenbaum, DS; Peterson, RT; Chakravarti, A; Kaab, S; Roden, DM; MacRae, CA,期刊:Circulation, 页码:553-U33 , 文章类型: Article,,卷期:2009年120-7]
- Background-Cardiac repolarization, the process by which cardiomyocytes return to their resting potential after each beat, is a highly regulated process that is critical for heart rhythm stability. Perturbations of cardia...
- Quality of Care for Acute Coronary Syndrome Patients With Known Atherosclerotic Disease Results From the Get With the Guidelines Program
[作者:Brilakis, ES; Hernandez, AF; Dai, D; Peterson, ED; Banerjee, S; Fonarow, GC; Cannon, CP; Bhatt, DL,期刊:Circulation, 页码:560-567 , 文章类型: Article,,卷期:2009年120-7]
- Background-Patients with prior atherosclerosis in 1 or more vascular territories (coronary, cerebrovascular, or peripheral arterial) who present with acute coronary syndromes have high cardiovascular risk and may benefit...
- Targeted Ablation of PINCH1 and PINCH2 From Murine Myocardium Results in Dilated Cardiomyopathy and Early Postnatal Lethality
[作者:Liang, XQ; Sun, YF; Ye, MQ; Scimia, MC; Cheng, HQ; Martin, J; Wang, G; Rearden, A; Wu, CY; Peterson, KL; Powell, HC; Evans, SM; Chen, J,期刊:Circulation, 页码:568-576 , 文章类型: Article,,卷期:2009年120-7]
- Background-PINCH proteins are 5 LIM domain-only adaptor proteins that function as key components of the integrin signaling pathway and play crucial roles in multiple cellular processes. Two PINCH proteins, PINCH1 and PIN...
- Impact of Myocardial Fibrosis in Patients With Symptomatic Severe Aortic Stenosis
[作者:Weidemann, F; Herrmann, S; Stork, S; Niemann, M; Frantz, S; Lange, V; Beer, M; Gattenlohner, S; Voelker, W; Ertl, G; Strotmann, JM,期刊:Circulation, 页码:577-584 , 文章类型: Article,,卷期:2009年120-7]
- Background-In this prospective follow-up study, the effect of myocardial fibrosis on myocardial performance in symptomatic severe aortic stenosis was investigated, and the impact of fibrosis on clinical outcome after aor...
- Subclinical Brain Embolization in Left-Sided Infective Endocarditis Results From the Evaluation by MRI of the Brains of Patients With Left-Sided Intracardiac Solid Masses (EMBOLISM) Pilot Study
[作者:Cooper, HA; Thompson, EC; Laureno, R; Fuisz, A; Mark, AS; Lin, M; Goldstein, SA,期刊:Circulation, 页码:585-591 , 文章类型: Article,,卷期:2009年120-7]
- Background-Acute brain embolization (ABE) in left-sided infective endocarditis has significant implications for clinical decision making. The true incidence of ABE, including subclinical brain embolization, is unknown.Me...
- Enzyme-Sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques
[作者:Ronald, JA; Chen, JW; Chen, YX; Hamilton, AM; Rodriguez, E; Reynolds, F; Hegele, RA; Rogers, KA; Querol, M; Bogdanov, A; Weissleder, R; Rutt, BK,期刊:Circulation, 页码:592-U92 , 文章类型: Article,,卷期:2009年120-7]
- Background-Inflammation undermines the stability of atherosclerotic plaques, rendering them susceptible to acute rupture, the cataclysmic event that underlies clinical expression of this disease. Myeloperoxidase is a cen...
- Sirolimus-Eluting Stent Treatment at High-Volume Centers Confers Lower Mortality at 6-Month Follow-Up Results From the Prospective Multicenter German Cypher Registry
[作者:Khattab, AA; Hamm, CW; Senges, J; Toelg, R; Geist, V; Bonzel, T; Kelm, M; Levenson, B; Nienaber, CA; Pfannebecker, T; Sabin, G; Schneider, S; Tebbe, U; Neumann, FJ; Richardt, G,期刊:Circulation, 页码:600-606 , 文章类型: Article,,卷期:2009年120-7]
- Background-Studies continue to identify percutaneous coronary intervention procedural volume both at the institutional level and at the operator level as being strongly correlated with outcome. High-volume centers have b...
- Tumor Suppressor Ras-Association Domain Family 1 Isoform A Is a Novel Regulator of Cardiac Hypertrophy
[作者:Oceandy, D; Pickard, A; Prehar, S; Zi, M; Mohamed, TMA; Stanley, PJ; Baudoin-Stanley, F; Nadif, R; Tommasi, S; Pfeifer, GP; Armesilla, AL; Cartwright, EJ; Neyses, L,期刊:Circulation, 页码:607-U125 , 文章类型: Article,,卷期:2009年120-7]
- Background-Ras signaling regulates a number of important processes in the heart, including cell growth and hypertrophy. Although it is known that defective Ras signaling is associated with Noonan, Costello, and other syn...
- Response Gene to Complement 32, a Novel Hypoxia-Regulated Angiogenic Inhibitor
[作者:An, XJ; Jin, Y; Guo, HN; Foo, SY; Cully, BL; Wu, JP; Zeng, HY; Rosenzweig, A; Li, J,期刊:Circulation, 页码:617-U141 , 文章类型: Article,,卷期:2009年120-7]
- Background-Response gene to complement 32 (RGC-32) is induced by activation of complement and regulates cell proliferation. To determine the mechanism of RGC-32 in angiogenesis, we examined the role of RGC-32 in hypoxia-...
- Functional Lecithin: Cholesterol Acyltransferase Is Not Required for Efficient Atheroprotection in Humans
[作者:Calabresi, L; Baldassarre, D; Castelnuovo, S; Conca, P; Bocchi, L; Candini, C; Frigerio, B; Amato, M; Sirtori, CR; Alessandrini, P; Arca, M; Boscutti, G; Cattin, L; Gesualdo, L; Sampietro, T; Vaudo, G; Veglia, F; Calandra, S; Franceschini, G,期刊:Circulation, 页码:628-635 , 文章类型: Article,,卷期:2009年120-7]
- Background-Mutations in the LCAT gene cause lecithin: cholesterol acyltransferase (LCAT) deficiency, a very rare metabolic disorder with 2 hypoalphalipoproteinemia syndromes: classic familial LCAT deficiency (Online Mend...
- Dronedarone
[作者:Patel, C; Yan, GX; Kowey, PR,期刊:Circulation, 页码:636-644 , 文章类型: Article,,卷期:2009年120-7]
- Amiodarone is the most effective antiarrhythmic drug for maintaining sinus rhythm for patients with atrial fibrillation. Extra-cardiac side effects have been a limiting factor, especially during chronic use, and may offs...
- Transesophageal Echocardiography During Ventricular Fibrillation
[作者:Cianciulli, TF; Ferreiro, DE; Davolos, DG; Saccheri, MC; Lax, JA; Prezioso, HA; Vidal, LA,期刊:Circulation, 页码:E43-E43 , 文章类型: Editorial Material,,卷期:2009年120-7]
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