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  • Tadalafil Therapy for Pulmonary Arterial Hypertension
    [作者:Galie, N; Brundage, BH; Ghofrani, HA; Oudiz, RJ; Simonneau, G; Safdar, Z; Shapiro, S; White, RJ; Chan, M; Beardsworth, A; Frumkin, L; Barst, RJ,期刊:Circulation, 页码:2894-U65 , 文章类型: Article,,卷期:2009年119-22]
  • Background-Treatment options for pulmonary arterial hypertension target the prostacyclin, endothelin, or nitric oxide pathways. Tadalafil, a phosphodiesterase type-5 inhibitor, increases cGMP, the final mediator in the n...
  • Regulatory T Cells Ameliorate Angiotensin II-Induced Cardiac Damage
    [作者:Kvakan, H; Kleinewietfeld, M; Qadri, F; Park, JK; Fischer, R; Schwarz, I; Rahn, HP; Plehm, R; Wellner, M; Elitok, S; Gratze, P; Dechend, R; Luft, FC; Muller, DN,期刊:Circulation, 页码:2904-U83 , 文章类型: Article,,卷期:2009年119-22]
  • Background-Hypertensive target organ damage, especially cardiac hypertrophy with heart failure and arrhythmia, is a major source of morbidity and mortality. Angiotensin II, a major mediator of hypertension and cardiac da...