- Structural Delineation of MDC1-FHA Domain Binding with CHK2-pThr68
[作者:Wu, HH; Wu, PY; Huang, KF; Kao, YY; Tsai, MD,期刊:Biochemistry, 页码:575-577 , 文章类型: Article,,卷期:2012年51-2]
- Mammalian MDC1 interacts with CHK2 in the regulation of DNA damage-induced S-phase checkpoint and apoptosis, which is directed by the association of MDC1-FHA and CHK2-pThr68. However, different ligand specificities of MD...
- Demonstration of Ligand Decoration, and Ligand-Induced Perturbation, of G-Quadruplexes in a Plasmid Using Atomic Force Microscopy
[作者:Mela, I; Kranaster, R; Henderson, RM; Balasubramanian, S; Edwardson, JM,期刊:Biochemistry, 页码:578-585 , 文章类型: Article,,卷期:2012年51-2]
- G-Quadruplexes are nucleic acid secondary structures consisting of a planar arrangement of four guanine residues. Potential G-quadruplex-forming sequences are widely distributed throughout the genome. Significantly, they...
- Second-Contact Shell Mutation Diminishes Streptavidin-Biotin Binding Affinity through Transmitted Effects on Equilibrium Dynamics
[作者:Baugh, L; Trong, IL; Cerutti, DS; Mehta, N; Gulich, S; Stayton, PS; Stenkamp, RE; Lybrand, TP,期刊:Biochemistry, 页码:597-607 , 文章类型: Article,,卷期:2012年51-2]
- We report a point mutation in the second contact shell of the high-affinity streptavidin-biotin complex that appears to reduce binding affinity through transmitted effects on equilibrium dynamics. The Y54F streptavidin m...
- Femtosecond Photodynamics of the Red/Green Cyanobacteriochrome NpR6012g4 from Nostoc punctiforme. 1. Forward Dynamics
[作者:Kim, PW; Freer, LH; Rockwell, NC; Martin, SS; Lagarias, JC; Larsen, DS,期刊:Biochemistry, 页码:608-618 , 文章类型: Article,,卷期:2012年51-2]
- Phytochromes are well-known red/far-red photosensory proteins that utilize the photoisomerization of a linear tetrapyrrole (bilin) chromophore to detect the ratio of red to far-red light. Cyanobacteriochromes (CBCRs) are...
- Femtosecond Photodynamics of the Red/Green Cyanobacteriochrome NpR6012g4 from Nostoc punctiforme. 2. Reverse Dynamics
[作者:Kim, PW; Freer, LH; Rockwell, NC; Martin, SS; Lagarias, JC; Larsen, DS,期刊:Biochemistry, 页码:619-630 , 文章类型: Article,,卷期:2012年51-2]
- Phytochromes are red/far-red photosensory proteins that utilize photoisomerization of a linear tetrapyrrole (bun) chromophore to photoconvert reversibly between red- and far-red-absorbing forms (P-r and P-fr, respectivel...
- Structure, Dynamics, and Antimicrobial and Immune Modulatory Activities of Human LL-23 and Its Single-Residue Variants Mutated on the Basis of Homologous Primate Cathelicidins
[作者:Wang, GS; Elliott, M; Cogen, AL; Ezell, EL; Gallo, RL; Hancock, REW,期刊:Biochemistry, 页码:653-664 , 文章类型: Article,,卷期:2012年51-2]
- LL-23 is a natural peptide corresponding to the 23 N-terminal amino acid residues of human host defense cathelicidin LL-37. LL-23 demonstrated, compared to LL-37, a conserved ability to induce the chemokine MCP-1 in huma...
- Structural and Biophysical Insights into the Ligand-Free Pitx2 Homeodomain and a Ring Dermoid of the Cornea Inducing Homeodomain Mutant
[作者:Doerdelmann, T; Kojetin, DJ; Baird-Titus, JM; Solt, LA; Burris, TP; Rance, M,期刊:Biochemistry, 页码:665-676 , 文章类型: Article,,卷期:2012年51-2]
- The homeodomain-containing transcription factor Pitx2 (pituitary homeobox protein 2) is present in many developing embryonic tissues, including the heart. Its homeodomain is responsible for the recognition and binding to...
- Post-Translational Modification of Cu/Zn Superoxide Dismutase under Anaerobic Conditions
[作者:Leitch, JM; Li, CX; Baron, JA; Matthews, LM; Cao, XH; Hart, PJ; Culotta, VC,期刊:Biochemistry, 页码:677-685 , 文章类型: Article,,卷期:2012年51-2]
- In eukaryotic organisms, the largely cytosolic copper- and zinc-containing superoxide dismutase (Cu/Zn SOD) enzyme represents a key defense against reactive oxygen toxicity. Although much is known about the biology of th...
- Ionic Residues of Human Serum Transferrin Affect Binding to the Transferrin Receptor and Iron Release
[作者:Steere, AN; Miller, BF; Roberts, SE; Byrne, SL; Chasteen, ND; Smith, VC; MacGillivray, RTA; Mason, AB,期刊:Biochemistry, 页码:686-694 , 文章类型: Article,,卷期:2012年51-2]
- Efficient delivery of iron is critically dependent on the binding of diferric human serum transferrin (hTF) to its specific receptor (TFR) on the surface of actively dividing cells. Internalization of the complex into an...
- Characterization of the Redox Activity and Disulfide Bond Formation in Apurinic/Apyrimidinic Endonuclease
[作者:Luo, MH; Zhang, J; He, HZ; Su, DA; Chen, QJ; Gross, ML; Kelley, MR; Georgiadis, MM,期刊:Biochemistry, 页码:695-705 , 文章类型: Article,,卷期:2012年51-2]
- Apurinic/apyrimidinic endonuclease (APE!) is an unusual nuclear redox factor in which the redox-active cysteines identified to date, C65 and C93, are surface inaccessible residues whose activities may be influenced by pa...
- Sgf29p Facilitates the Recruitment of TATA Box Binding Protein but Does Not Alter SAGA's Global Structural Integrity in Vivo
[作者:Shukla, A; Lahudkar, S; Durairaj, G; Bhaumik, SR,期刊:Biochemistry, 页码:706-714 , 文章类型: Article,,卷期:2012年51-2]
- Although Sgf29p has been biochemically implicated as a component of SAGA (Spt-Ada-Gcn5 acetyltransferase), its precise mechanism of action in transcription is not clearly understood in vivo. Here, using a formaldehyde-ba...
- Structure-Based Discovery of a Novel Inhibitor Targeting the beta-Catenin/Tcf4 Interaction
[作者:Tian, W; Han, XF; Yan, MC; Xu, Y; Duggineni, S; Lin, N; Luo, GF; Li, YM; Han, XB; Huang, ZW; An, J,期刊:Biochemistry, 页码:724-731 , 文章类型: Article,,卷期:2012年51-2]
- Overactivation or overexpression of beta-catenin in the Wnt (wingless) signaling pathway plays an important role in tumorigenesis. Interaction of beta-catenin with T-cell factor (Tcf) DNA binding proteins is a key step i...
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