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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   India's growing participation in global clinical trials [作者：Gupta, YK; Padhy, BM,期刊：Trends in Pharmacological Sciences, 页码：327-329 , 文章类型： Editorial Material，,卷期：2011年32-6] Lower operational costs, recent regulatory reforms and several logistic advantages make India an attractive destination for conducting clinical trials. Efforts for maintaining stringent ethical standards and the launch o... Biosensor diagnosis of urinary tract infections: a path to better treatment? [作者：Mach, KE; Wong, PK; Liao, JC,期刊：Trends in Pharmacological Sciences, 页码：330-336 , 文章类型： Article，,卷期：2011年32-6] Urinary tract infection (UTI) is among the most common bacterial infections and poses a significant healthcare burden. The standard culture-based diagnosis of UTI has a typical delay of two to three days. In the absence ... Treating brain tumors with PDE4 inhibitors [作者：Sengupta, R; Sun, T; Warrington, NM; Rubin, JB,期刊：Trends in Pharmacological Sciences, 页码：337-344 , 文章类型： Article，,卷期：2011年32-6] Speculation regarding dysregulation of cAMP metabolism in oncogenesis has existed since the discovery of cAMP more than 50 years ago. Recent data confirm the relevance of disordered cAMP metabolism to the genesis of mult... ET(A)-receptor antagonists or allosteric modulators? [作者：De Mey, JGR; Compeer, MG; Lemkens, P; Meens, MJPMT,期刊：Trends in Pharmacological Sciences, 页码：345-351 , 文章类型： Article，,卷期：2011年32-6] The paracrine signaling peptide endothelin-1 (ET1) is involved in cardiovascular diseases, cancer and chronic pain. It acts on class A G-protein-coupled receptors (GPCRs) but displays atypical pharmacology. It binds tigh... Emerging migraine treatments and drug targets [作者：Olesen, J; Ashina, M,期刊：Trends in Pharmacological Sciences, 页码：352-359 , 文章类型： Review，,卷期：2011年32-6] Migraine has a 1-year prevalence of 10% and high socioeconomic costs. Despite recent drug developments, there is a huge unmet need for better pharmacotherapy. In this review we discuss promising anti-migraine strategies ... Phosphodiesterases and cardiac cGMP: evolving roles and controversies [作者：Zhang, ML; Kass, DA,期刊：Trends in Pharmacological Sciences, 页码：360-365 , 文章类型： Review，,卷期：2011年32-6] cGMP and its primary target kinase, protein kinase G (PKG), are well recognized modulators of cardiac function and the chronic stress response. Their enhancement appears to serve as a myocardial brake, reducing maladapti... Structural and functional differences between L-type calcium channels: crucial issues for future selective targeting [作者：Zuccotti, A; Clementi, S; Reinbothe, T; Torrente, A; Vandael, DH; Pirone, A,期刊：Trends in Pharmacological Sciences, 页码：366-375 , 文章类型： Review，,卷期：2011年32-6] Within the family of voltage-gated calcium channels (VGCCs), L-type channels (L-VGCCs) represent a well-established therapeutic target for calcium channel blockers, which are widely used to treat hypertension and myocard...