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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共35条记录   Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice [作者：Tobin, V; Le Gall, M; Fioramonti, X; Stolarczyk, E; Blazquez, AG; Klein, C; Prigent, M; Serradas, P; Cuif, MH; Magnan, C; Leturque, A; Brot-Laroche, E,期刊：Diabetes, 页码：555-562 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVES-A physiological adaptation to a sugar-rich meal is achieved by increased sugar uptake to match dietary load, resulting from a rapid transient translocation of the fructose/glucose GLUT2 transporter to the brus... Retinal arteriolar narrowing predicts incidence of diabetes - The Australian diabetes, obesity and lifestyle (AusDiab) study [作者：Nguyen, TT; Wang, JJ; Islam, FMA; Mitchen, P; Tapp, RJ; Zimmet, PZ; Simpson, R; Shaw, J; Wong, TY,期刊：Diabetes, 页码：536-539 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-To examine the relationship of retinal vascular caliber to incident diabetes in a population-based cohort.RESEARCH DESIGN AND METHODS-The Australian Dia;betes, Obesity and Lifestyle (AusDiab) Study recruited ad... Insulin signaling stimulates insulin transport by bovine aortic endothelial cells [作者：Wang, H; Wang, AX; Liu, ZQ; Barrett, EJ,期刊：Diabetes, 页码：540-547 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-In vivo evidence suggests that insulin entry into skeletal muscle is rate limiting for its overall metabolic action. Although there has been controversy regarding whether insulin crosses the endothelium by a pa... The role of free-living daily walking in human weight gain and obesity [作者：Levine, JA; McCrady, SK; Lanningham-Foster, LM; Kane, PH; Foster, RC; Manohar, CU,期刊：Diabetes, 页码：548-554 , 文章类型： Article，,卷期：2008年57-3] OBJECTI'VE-Diminished daily physical activity explains, in part, why obesity and diabetes have become worldwide epidemics. In particular, chair use has replaced ambulation, so that obese individuals tend to sit for simil... Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets [作者：Shu, L; Sauter, NS; Schulthess, FT; Matveyenko, AV; Oberholzer, J; Maedler, K,期刊：Diabetes, 页码：645-653 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-Type 2 diabetes is characterized by impaired insulin secretion in response to increased metabolic demand. This defect in beta-cell compensation seems to result from the interplay between environmental factors a... Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling [作者：Calvert, JW; Gundewar, S; Jha, S; Greer, JJM; Bestermann, WH; Tian, R; Lefer, DJ,期刊：Diabetes, 页码：696-705 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-Clinical studies have reported that metformin reduces cardiovascular end points of type 2 diabetic subjects by actions that cannot solely be attributed to glucose-lowering effects. The therapeutic effects of me... Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries [作者：Bakker, W; Sipkema, P; Stehouwer, CDA; Serne, EH; Smulders, YM; van Hinsbergh, VWM; Eringa, EC,期刊：Diabetes, 页码：706-713 , 文章类型： Article，,卷期：2008年57-3] OBJECTIEVE-Protein kinase C (PKC) theta activation is associated with insulin resistance and obesity, but the underlying mechanisms have not been fully elucidated. Impairment of insulin-mediated vasoreactivity in muscle ... A central role for neuronal AMP-Activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss [作者：Ropelle, ER; Pauli, JR; Fernandes, MFA; Rocco, SA; Marin, RM; Morari, J; Souza, KK; Dais, MM; Gomes-Marcondes, MC; Gontijo, JAR; Franchini, KG; Velloso, LA; Saad, MJA; Carvalheira, JBC,期刊：Diabetes, 页码：594-605 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-A high-protein diet (HPD) is known to promote the reduction of body fat, but the mechanisms underlying this change are unclear. AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) funct... Defining pancreatic endocrine precursors and their descendants [作者：White, P; May, CL; Lamounier, RN; Brestelli, JE; Kaestner, KH,期刊：Diabetes, 页码：654-668 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-The global incidence of diabetes continues to increase. Cell replacement therapy and islet transplantation offer hope, especially for severely affected patients. Efforts to differentiate insulin-producing P-cel... Postnatal programming of glucocorticoid metabolism in rats modulates high-fat diet-induced regulation of visceral adipose tissue glucocorticoid exposure and sensitivity and adiponectin and proinflammatory adipokines gene expression in adulthood [作者：Boullu-Ciocca, S; Achard, V; Tassistro, V; Dutour, A; Grino, M,期刊：Diabetes, 页码：669-677 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-Alterations of the perinatal environment, which lead to increased prevalence of the metabolic syndrome in adulthood, program an upregulation of systemic and/or adipose tissue glucocorticoid metabolism (11 beta-... Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control [作者：Kolavennu, V; Zeng, L; Peng, H; Wang, Y; Danesh, FR,期刊：Diabetes, 页码：714-723 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-RhoA, a small GTPase protein, and its immediate downstream target, Rho kinase (ROCK), control a wide variety of signal transduction pathways. Recent studies have shown that fasudil, a selective ROCK inhibitor, ... Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes Mellitus 1 year postpartum [作者：Friedman, JE; Kirwan, JP; Jing, M; Presley, L; Catalano, PM,期刊：Diabetes, 页码：606-613 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-Women with gestational diabetes mellitus (GDM) demonstrate chronic and progressive insulin resistance and a markedly increased risk of converting to type 2 diabetes after pregnancy. However, the cellular mechan... In vitro hyperglycemia or a diabetic intrauterine environment reduces neonatal endothelial colony-forming cell numbers and function [作者：Ingram, DA; Lien, IZ; Mead, LE; Estes, M; Prater, DN; Derr-Yellin, E; DiMeglio, LA; Haneline, LS,期刊：Diabetes, 页码：724-731 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-Emerging data demonstrate that maternal diabetes has long-term health consequences for offspring, including the development of hypertension. In adults, circulating endothelial progenitor cells (EPCs) participat... Delayed recovery of cognitive function following hypoglycemia in adults with type 1 diabetes - Effect of impaired awareness of hypoglycemia [作者：Zammitt, NN; Warren, RE; Deary, IJ; Frier, BM,期刊：Diabetes, 页码：732-736 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-Recovery times of cognitive functions were examined after exposure to hypoglycemia in people with diabetes with and without impaired hypoglycemia awareness.RESEARCH DESIGN AND METHODS-A total of 36 subjects wit... Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure [作者：Nakae, J; Cao, Y; Oki, M; Orba, Y; Sawa, H; Kiyonari, H; Iskandar, K; Suga, K; Lombes, M; Hayashi, Y,期刊：Diabetes, 页码：563-576 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-Adipose tissue serves as an integrator of various physiological pathways, energy balance, and glucose homeostasis. Forkhead box-containing protein O subfamily (FoxO) 1 mediates insulin action at the transcripti... Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats [作者：Shapiro, A; Matheny, M; Zhang, Y; Tumer, N; Cheng, KY; Rogrigues, E; Zolotukhin, S; Scarpace, PJ,期刊：Diabetes, 页码：614-622 , 文章类型： Article，,卷期：2008年57-3] OBJECTIVE-We examined whether chronic leptin treatment of diet-induced obese rats promotes or alleviates the susceptibility to continued high-fat feeding. Second, we examined if voluntary wheel running is beneficial in r...