- Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake
[作者：Sandoval, DA; Bagnol, D; Woods, SC; D'Alessio, DA; Seeley, RJ,期刊：Diabetes, 页码：2046-2054 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-Glucagon-like peptide-1 (GLP-1) promotes glucose homeostasis through regulation of islet hormone secretion, as well as hepatic and gastric function. Because GLP-1 is also synthesized in the brain, where it regu...
- The human lipodystrophy gene BSCL2/Seipin may be essential for normal adipocyte differentiation
[作者：Payne, VA; Grimsey, N; Tuthill, A; Virtue, S; Gray, SL; Nora, ED; Semple, RK; O'Rahilly, S; Rochford, JJ,期刊：Diabetes, 页码：2055-2060 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is a recessive disorder featuring near complete absence of adipose tissue. Remarkably, although the causative gene, BSCL2, has been known for several ye...
- Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism
[作者：Dallaire, P; Bellmann, K; Laplante, M; Gelinas, S; Centeno-Baez, C; Penfornis, P; Peyot, ML; Latour, MG; Lamontagne, J; Trujillo, ME; Scherer, PE; Prentki, M; Deshaies, Y; Marette, A,期刊：Diabetes, 页码：1999-2011 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-Synthetic ligands for peroxisome proliferatoractivated receptor-gamma (PPAR-gamma) improve insulin sensitivity in obesity, but it is still unclear whether inflammatory signals modulate their metabolic actions. ...
- Hypothalamic protein kinase C regulates glucose production
[作者：Ross, R; Wang, PYT; Chari, M; Lam, CKL; Caspi, L; Ono, H; Muse, ED; Li, XS; Gutierrez-Juarez, R; Light, PE; Schwartz, GJ; Rossetti, L; Lam, TKT,期刊：Diabetes, 页码：2061-2065 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-A selective rise in hypothalamic lipid metabolism and the subsequent activation of SUR1/Kir6.2 ATP-sensitive K+ (K-ATP) channels inhibit hepatic glucose production. The mechanisms that link the ability of hypot...
- Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth
[作者：Kloting, N; Koch, L; Wunderlich, T; Kern, M; Ruschke, K; Krone, W; Bruning, JC; Bluher, M,期刊：Diabetes, 页码：2074-2082 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-IGF-1 and the IGF-1 receptor (IGF-1R) have been implicated in the regulation of adipocyte differentiation and lipid accumulation in vitro.RESEARCH DESIGN AND METHODS-To investigate the role of IGF-1 receptor in...
- Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic rnitochondrial metabolism
[作者：Satapati, S; He, T; Inagaki, T; Potthoff, M; Merritt, ME; Esser, V; Mangelsdorf, DJ; Kliewer, SA; Browning, JD; Burgess, SC,期刊：Diabetes, 页码：2012-2021 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-Fluxes through mitochondrial pathways are defective in insulin-resistant skeletal muscle, but it is unclear whether similar mitochondrial defects play a role in the liver during insulin resistance and/or diabet...
- Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1 alpha in hepatic insulin resistance
[作者：Kumashiro, N; Tamura, Y; Uchida, T; Ogihara, T; Fujitani, Y; Hirose, T; Mochizuki, H; Kawamori, R; Watada, H,期刊：Diabetes, 页码：2083-2091 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-Recent studies identified accumulation of reactive oxygen species (ROS) as a common pathway causing insulin resistance. However, whether and how the reduction of ROS levels improves insulin resistance remains t...
- Relationship of abdominal visceral and subcutaneous adipose tissue with lipoprotein particle number and size in type 2 diabetes
[作者：Sam, S; Haffner, S; Davidson, MH; D'Agostino, RB; Feinstein, S; Kondos, G; Perez, A; Mazzone, T,期刊：Diabetes, 页码：2022-2027 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-Insulin resistance and type 2 diabetes are associated with an atherogenic lipoprotein profile. We examined the role of visceral and subcutaneous fat depots, independent of BMI, on the dyslipidemia associated wi...
- Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance
[作者：Bell, M; Wang, H; Chen, H; McLenithan, JC; Gong, DW; Yang, RZ; Yu, DZ; Fried, SK; Quon, MJ; Londos, C; Sztalryd, C,期刊：Diabetes, 页码：2037-2045 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-Accumulation of intracellular lipid droplets (LDs) in non-adipose tissues is recognized as a strong prognostic factor for the development of insulin resistance in obesity. LDs are coated with perilipin, adipose...
- Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes
[作者：Tedesco, L; Valerio, A; Cervino, C; Cardile, A; Pagano, C; Vettor, R; Pasquali, R; Carruba, MO; Marsicano, G; Lutz, B; Pagotto, U; Nisoli, E,期刊：Diabetes, 页码：2028-2036 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-Cannabinoid type 1 (CB1) receptor blockade decreases body weight and adiposity in obese subjects; however, the underlying mechanism is not yet fully understood. Nitric oxide (NO) produced by endothelial NO synt...
- T-cell promiscuity in autoimmune diabetes
[作者：Li, L; Wang, B; Frelinger, JA; Tisch, R,期刊：Diabetes, 页码：2099-2106 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-It is well established that the primary mediators of beta-cell destruction in type 1 diabetes are T-cells. Nevertheless, the molecular basis for recognition of beta-cell-specific epitopes by pathogenic T-cells ...
- Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
[作者：Ng, MCY; Park, KS; Oh, B; Tam, CHT; Cho, YM; Shin, HD; Lam, VKL; Ma, RCW; So, WY; Cho, YS; Kim, HL; Lee, HK; Chan, JCN; Cho, NH,期刊：Diabetes, 页码：2226-2233 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-Recent genome-wide association studies have identified six novel genes for type 2 diabetes and obesity and confirmed TCF7L2 as the major type 2 diabetes gene to date in Europeans. However, the implications of t...
- Role of the transcription factor Sox4 in insulin secretion and impaired glucose tolerance
[作者：Goldsworthy, M; Hugill, A; Freeman, H; Horner, E; Shimomura, K; Bogani, D; Pieles, G; Mijat, V; Arkell, R; Bhattacharya, S; Ashcroft, FM; Cox, RD,期刊：Diabetes, 页码：2234-2244 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVES-To identify, map, clone, and functionally validate a novel mouse model for impaired glucose tolerance and insulin secretion.RESEARCH DESIGN AND METHODS-Haploinsufficiency of the insulin receptor and associated...
- Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population
[作者：Chang, YC; Liu, PH; Lee, WJ; Chang, TJ; Jiang, YD; Li, HY; Kuo, SS; Lee, KC; Chuang, LM,期刊：Diabetes, 页码：2245-2252 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and typ...
- Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes
[作者：Besin, G; Gaudreau, S; Menard, M; Guindi, C; Dupuis, G; Amrani, A,期刊：Diabetes, 页码：2107-2117 , 文章类型： Article，,卷期：2008年57-8]
- OBJECTIVE-Autoimmune diabetes in the nonobese diabetic (NOD) mouse model results from a breakdown of T-cell tolerance caused by impaired tolerogenic dendritic cell development and regulatory T-cell (Treg) differentiation...
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