- Alteration in the Gene Encoding Protein Tyrosine Phosphatase Nonreceptor Type 6 (PTPN6/SHP1) May Contribute to Neutrophilic Dermatoses
[作者:Nesterovitch, AB; Gyorfy, Z; Hoffman, MD; Moore, EC; Elbuluk, N; Tryniszewska, B; Rauch, TA; Simon, M; Kang, S; Fisher, GJ; Mikecz, K; Tharp, MD; Glant, TT,期刊:American Journal of Pathology, 页码:1434-1441 , 文章类型: Article,,卷期:2011年178-4]
- We have found a B2 repeat insertion in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6) in a mouse that developed a skin disorder with clinical and histopathological features resembling those see...
- Somatic Mutations of PPP2R1A in Ovarian and Uterine Carcinomas
[作者:Shih, IM; Panuganti, PK; Kuo, KT; Mao, TL; Kuhn, E; Jones, S; Velculescu, VE; Kurman, RJ; Wang, TL,期刊:American Journal of Pathology, 页码:1442-1447 , 文章类型: Article,,卷期:2011年178-4]
- Exome sequencing of ovarian clear-cell carcinoma has identified somatic mutations in PPP2R1A, a subunit of protein phosphatase 2A. The present study was performed to determine the frequency of PPP2R1A mutations in exon 5...
- Helicobacter pylori Induction of Eosinophil Migration Is Mediated by the cag Pathogenicity Island via Microbial-Epithelial Interactions
[作者:Nagy, TA; Allen, SS; Wroblewski, LE; Flaherty, DK; Slaughter, JC; Perez-Perez, G; Israel, DA; Peek, RM,期刊:American Journal of Pathology, 页码:1448-1452 , 文章类型: Article,,卷期:2011年178-4]
- The host immune response directed against Helicobacter pylori is ineffective in eliminating the organism and strains harboring the cag pathogenicity island augment disease risk. Because eosinophils are a prominent compon...
- Pulmonary Mycobacterial Granuloma Increased IL-10 Production Contributes to Establishing a Symbiotic Host-Microbe Microenvironment
[作者:Shaler, CR; Kugathasan, K; McCormick, S; Damjanovic, D; Horvath, C; Small, CL; Jeyanathan, M; Chen, X; Yang, PC; Xing, Z,期刊:American Journal of Pathology, 页码:1622-1634 , 文章类型: Article,,卷期:2011年178-4]
- The granuloma, a hallmark of host defense against pulmonary mycobacterial infection, has long been believed to be an active type 1 immune environment. However, the mechanisms regarding why granuloma fails to eliminate my...
- Early Acceptance of Renal Allografts in Mice Is Dependent on Foxp3(+) Cells
[作者:Miyajima, M; Chase, CM; Alessandrini, A; Farkash, EA; Della Pelle, P; Benichou, G; Graham, JA; Madsen, JC; Russell, PS; Colvin, RB,期刊:American Journal of Pathology, 页码:1635-1645 , 文章类型: Article,,卷期:2011年178-4]
- Mouse renal allografts have a remarkable ability to promote acceptance across full major histocompatibility complex incompatibilities in certain strain combinations without immunosuppression. The mechanism is unknown but...
- Increased CDK5 Expression in HIV Encephalitis Contributes to Neurodegeneration via Tau Phosphorylation and Is Reversed with Roscovitine
[作者:Patrick, C; Crews, L; Desplats, P; Dumaop, W; Rockenstein, E; Achim, CL; Everall, IP; Masliah, E,期刊:American Journal of Pathology, 页码:1646-1661 , 文章类型: Article,,卷期:2011年178-4]
- Recent treatments with highly active antiretroviral therapy (HAART) regimens have been shown to improve general clinical status in patients with human immunodeficiency virus (HIV) infection; however, the prevalence of co...
- Association of T-Zone Reticular Networks and Conduits with Ectopic Lymphoid Tissues in Mice and Humans
[作者:Link, A; Hardie, DL; Favre, S; Britschgi, MR; Adams, DH; Sixt, M; Cyster, JG; Buckley, CD; Luther, SA,期刊:American Journal of Pathology, 页码:1662-1675 , 文章类型: Article,,卷期:2011年178-4]
- Ectopic or tertiary lymphoid tissues (TLTs) are often induced at sites of chronic inflammation. They typically contain various hematopoietic cell types, high endothelial venules, and follicular dendritic cells; and are o...
- Expression of Prostaglandin E Synthases in Periodontitis Immunolocalization and Cellular Regulation
[作者:Bage, T; Kats, A; Lopez, BS; Morgan, G; Nilsson, G; Burt, I; Korotkova, M; Corbett, L; Knox, AJ; Pino, L; Jakobsson, PJ; Modeer, T; Yucel-Lindberg, T,期刊:American Journal of Pathology, 页码:1676-1688 , 文章类型: Article,,卷期:2011年178-4]
- The inflammatory mediator prostaglandin E(2) (PGE(2)) is implicated in the pathogenesis of chronic inflammatory diseases including periodontitis; it is synthesized by cyclooxygenases (COX) and the prostaglandin E synthas...
- Plague in Guinea Pigs and Its Prevention by Subunit Vaccines
[作者:Quenee, LE; Ciletti, N; Berube, B; Krausz, T; Elli, D; Hermanas, T; Schneewind, O,期刊:American Journal of Pathology, 页码:1689-1700 , 文章类型: Article,,卷期:2011年178-4]
- Human pneumonic plague is a devastating and transmissible disease for which a Food and Drug Administration approved vaccine is not available. Suitable animal models may be adopted as a surrogate for human plague to fulfi...
- Spontaneous Insertion of a B2 Element in the Ptpn6 Gene Drives a Systemic Autoinflammatory Disease in Mice Resembling Neutrophilic Dermatosis in Humans
[作者:Nesterovitch, AB; Szanto, S; Gonda, A; Bardos, T; Kis-Toth, K; Adarichev, VA; Olasz, K; Ghassemi-Najad, S; Hoffman, MD; Tharp, MD; Mikecz, K; Glant, TT,期刊:American Journal of Pathology, 页码:1701-1714 , 文章类型: Article,,卷期:2011年178-4]
- We found a spontaneous autosomal mutation in a mouse leading to neutrophil infiltration with ulceration in the upper dermis of homozygous offspring. These animals had increased neutrophil numbers, associated with normal ...
- Obesity and Hepatosteatosis in Mice with Enhanced Oxidative DNA Damage Processing in Mitochondria
[作者:Zhang, HH; Xie, CH; Spencer, HJ; Zuo, CL; Higuchi, M; Ranganathan, G; Kern, PA; Chou, MW; Huang, Q; Szczesny, B; Mitra, S; Watson, AJ; Margison, GP; Fan, CY,期刊:American Journal of Pathology, 页码:1715-1727 , 文章类型: Article,,卷期:2011年178-4]
- Mitochondria play critical roles in oxidative phosphorylation and energy metabolism. Increasing evidence supports that mitochondrial DNA (mtDNA) damage and dysfunction play vital roles in the development of many mitochon...
- PGC-1 alpha Promotes Nitric Oxide Antioxidant Defenses and Inhibits FOXO Signaling Against Cardiac Cachexia in Mice
[作者:Geng, TY; Li, P; Yin, XH; Yan, Z,期刊:American Journal of Pathology, 页码:1738-1748 , 文章类型: Article,,卷期:2011年178-4]
- Chronic heart failure often results in catabolic muscle wasting, exercise intolerance, and death. Oxidative muscles, which have greater expression of the metabolic master gene peroxisome proliferator activated receptor-g...
- Caveolin-1 Deletion Reduces Early Brain Injury after Experimental Intracerebral Hemorrhage
[作者:Chang, CF; Chen, SF; Lee, TS; Lee, HF; Chen, SF; Shyue, SK,期刊:American Journal of Pathology, 页码:1749-1761 , 文章类型: Article,,卷期:2011年178-4]
- Intracerebral hemorrhage (ICH) is a subtype of stroke with high rates of morbidity and mortality. Caveolin-1 (Cav-1) is the main structural protein of caveolae and is involved in regulating signal transduction and choles...
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