- SPANosomes as Delivery Vehicles for Small Interfering RNA (siRNA)
[作者:Zhou, CG; Mao, YC; Sugimoto, Y; Zhang, Y; Kanthamneni, N; Yu, B; Brueggemeier, RW; Lee, LJ; Lee, RJ,期刊:Molecular Pharmaceutics, 页码:201-210 , 文章类型: Article,,卷期:2012年9-2]
- Nonionic surfactant vesicles, or SPANosomes (SPs), comprised of cationic lipid and sorbitan monooleate (Span 80) were synthesized and evaluated as small interfering RNA (siRNA) vectors. The SPs had a mean diameter of les...
- The Natural Cell-Penetrating Peptide Crotamine Targets Tumor Tissue in Vivo and Triggers a Lethal Calcium-Dependent Pathway in Cultured Cells
[作者:Nascimento, FD; Sancey, L; Pereira, A; Rome, C; Oliveira, V; Oliveira, EB; Nader, HB; Yamane, T; Kerkis, I; Tersariol, ILS; Coll, JL; Hayashi, MAF,期刊:Molecular Pharmaceutics, 页码:211-221 , 文章类型: Article,,卷期:2012年9-2]
- Our goal was to demonstrate the in vivo tumor specific accumulation of crotamine, a natural peptide from the venom of the South American rattlesnake Crotalus durissus terrificus, which has been characterized by our group...
- Paclitaxel/Tetrandrine Coloaded Nanoparticles Effectively Promote the Apoptosis of Gastric Cancer Cells Based on "Oxidation Therapy"
[作者:Li, XL; Lu, XW; Xu, HE; Zhu, ZS; Yin, HT; Qian, XP; Li, RT; Jiang, XQ; Liu, BR,期刊:Molecular Pharmaceutics, 页码:222-229 , 文章类型: Article,,卷期:2012年9-2]
- Paclitaxel (Ptx) has demonstrated encouraging activity in the treatment of gastric cancer. Development of drug-containing biodegradable polymeric nanoparticles (np) becomes one of the solutions to relieve side effects of...
- Enhancement of the Targeting Capabilities of the Paclitaxel-Loaded Pluronic Nanoparticles with a Glycol Chitosan/Heparin Composite
[作者:Yuk, SH; Oh, KS; Cho, SH; Kim, SY; Oh, S; Lee, JH; Kim, K; Kwon, IC,期刊:Molecular Pharmaceutics, 页码:230-236 , 文章类型: Article,,卷期:2012年9-2]
- An enhancement of tumor-targeting capability was demonstrated with paclitaxel (PTX)-loaded Pluronic nanoparticles (NPs) with immobilized glycol chitosan and heparin. The PTX-loaded Pluronic NPs were prepared as described...
- Oligoclonal Antibody Targeting Ghrelin Increases Energy Expenditure and Reduces Food Intake in Fasted Mice
[作者:Zakhari, JS; Zorrilla, EP; Zhou, B; Mayorov, AV; Janda, KD,期刊:Molecular Pharmaceutics, 页码:281-289 , 文章类型: Article,,卷期:2012年9-2]
- Ghrelin, an enteric peptide hormone linked to the pathophysiology of obesity has been a therapeutic target of great interest over the past decade. Many research efforts have focused on the antagonism of ghrelin's endogen...
- Synthesis, Optimization, and Characterization of Camptothecin-Loaded Acetalated Dextran Porous Microparticles for Pulmonary Delivery
[作者:Meenach, SA; Kim, YJ; Kauffman, KJ; Kanthamneni, N; Bachelder, EM; Ainslie, KM,期刊:Molecular Pharmaceutics, 页码:290-298 , 文章类型: Article,,卷期:2012年9-2]
- We propose the use of a new biopolymer, acetalated dextran (Ac-DEX), to synthesize porous microparticles for pulmonary drug delivery. Ac-DEX is derived from the polysaccharide dextran and, unlike polyesters, has tunable ...
- Characterization of in Vivo Disulfide-Reduction Mediated Drug Release in Mouse Kidneys
[作者:Yang, JJ; Kularatne, SA; Chen, XM; Low, PS; Wang, E,期刊:Molecular Pharmaceutics, 页码:310-317 , 文章类型: Article,,卷期:2012年9-2]
- Due to the overexpression of a folate receptor (FR) on many malignant cells, folate-targeted drugs have been developed to improve the cancer specificity of chemotherapeutic agents. Therapeutic index is further enhanced w...
- Probing Influence of Mesophasic Transformation on Performance of Self-Emulsifying System: Effect of Ion
[作者:Patil, SS; Venugopal, E; Bhat, S; Mahadik, KR; Paradkar, AR,期刊:Molecular Pharmaceutics, 页码:318-324 , 文章类型: Article,,卷期:2012年9-2]
- Self-emulsifying systems are mixtures of oils and surfactants, ideally isotropic, sometimes including cosolvents, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the ga...
- Specific Inhibition of the Transcription Factor Ci by a Cobalt(III) Schiff Base-DNA Conjugate
[作者:Hurtado, RR; Harney, AS; Heffern, MC; Holbrook, RJ; Holmgren, RA; Meade, TJ,期刊:Molecular Pharmaceutics, 页码:325-333 , 文章类型: Article,,卷期:2012年9-2]
- We describe the use of Co(III) Schiff base-DNA conjugates, a versatile class of research tools that target C2H2 transcription factors, to inhibit the Hedgehog (Hh) pathway. In developing mammalian embryos, Hh signaling i...
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