- Intravascular drug release kinetics dictate arterial drug deposition, retention, and distribution
[作者:Balakrishnan, B; Dooley, JF; Kopia, G; Edelman, ER,期刊:Journal of controlled release, 页码:100-108 , 文章类型: Article,,卷期:2007年123-2]
- Millions of patients worldwide have received drug-eluting stents to reduce their risk for in-stent restenosis. The efficacy and toxicity of these local therapeutics depend upon arterial drug deposition, distribution, and...
- Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly (beta-amino ester) block copolymer micelles for cancer therapy
[作者:Ko, J; Park, K; Kim, YS; Kim, MS; Han, JK; Kim, K; Park, RW; Kim, IS; Song, HK; Lee, DS; Kwon, IC,期刊:Journal of controlled release, 页码:109-115 , 文章类型: Article,,卷期:2007年123-2]
- The main objective of this study was to develop and characterize a pH-responsive and biodegradable polymeric micelle as a tumor-targeting drug delivery system. The pH-responsive block copolymer was synthesized by a Micha...
- Prevention of tumor recurrence and distant metastasis formation in a breast cancer mouse model by biodegradable implant of I-131-norcholesterol
[作者:Azab, AK; Kleinstern, J; Doviner, V; Orkin, B; Srebnik, M; Nissan, A; Rubinstein, A,期刊:Journal of controlled release, 页码:116-122 , 文章类型: Article,,卷期:2007年123-2]
- Brachytherapy has many potential roles in cancer therapy. However, major constraints are associated with placement and removal procedures of the brachytherapy machinery. An attractive approach would be the use of a biode...
- Sustained delivery of IL-1Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases
[作者:Lavi, G; Voronov, E; Dinarello, CA; Apte, RN; Cohen, S,期刊:Journal of controlled release, 页码:123-130 , 文章类型: Article,,卷期:2007年123-2]
- The interleukin-I receptor antagonist (IL-1 Ra) is approved for treating rheumatoid arthritis and has the potential to treat metastatic cancers involving excess amounts of the pro-inflammatory cytokine, interleukin-1 bet...
- Dennal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes
[作者:Dubey, V; Mishra, D; Dutta, T; Nahar, M; Saraf, DK; Jain, NK,期刊:Journal of controlled release, 页码:148-154 , 文章类型: Article,,卷期:2007年123-2]
- The aim of the current investigation is to evaluate the transdermal potential of novel vesicular carrier, ethosomes, bearing methotrexate (MTX), an anti-psoriatic, anti-neoplastic, highly hydrosoluble agent having limite...
- A newly developed oral heparin derivative for deep vein thrombosis: Non-human primate study
[作者:Kim, SK; Lee, DY; Kim, CY; Nam, JH; Moon, HT; Byun, Y,期刊:Journal of controlled release, 页码:155-163 , 文章类型: Article,,卷期:2007年123-2]
- The development of orally active heparin will have tremendous clinical importance since it can be used to effectively prevent deep vein thrombosis (DVT) in a long-term chronic treatment. We developed in this study a new ...
- Retargeting of adenoviral gene delivery via Herceptin-PEG-adenovirus conjugates to breast cancer cells
[作者:Jung, Y; Park, HJ; Kim, PH; Lee, J; Hyung, W; Yang, J; Ko, H; Sohn, JH; Kim, JH; Huh, YM; Yun, CO; Haam, S,期刊:Journal of controlled release, 页码:164-171 , 文章类型: Article,,卷期:2007年123-2]
- Targeted adenoviral gene delivery using human epidermal growth factor receptor 2 (HER2/neu) is one of the promising strategies for enhancing the transduction efficacy of PEGylated adenovirus (PEG-ADV). The viral capsid o...
- Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model
[作者:Kim, GY; Tyler, BM; Tupper, MM; Karp, JM; Langer, RS; Brem, H; Cima, MJ,期刊:Journal of controlled release, 页码:172-178 , 文章类型: Article,,卷期:2007年123-2]
- Sustained local delivery of single agents and controlled delivery of multiple chemotherapeutic agents are sought for the treatment of brain cancer. A resorbable, multi-reservoir polymer microchip drug delivery system has...
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