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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   PDZ domains: the building blocks regulating tumorigenesis [作者：Subbaiah, VK; Kranjec, C; Thomas, M; Banks, L,期刊：Biochemical Journal, 页码：195-205 , 文章类型： Review，,卷期：2011年439-2] Over 250 PDZ (PSD95/Dlg/ZO-1) domain-containing proteins have been described in the human proteome. As many of these possess multiple PDZ domains, the potential combinations of associations with proteins that possess PBM... Optimized native gel systems for separation of thylakoid protein complexes: novel super- and mega-complexes [作者：Jarvi, S; Suorsa, M; Paakkarinen, V; Aro, EM,期刊：Biochemical Journal, 页码：207-214 , 文章类型： Article，,卷期：2011年439-2] Gel-based analysis of thylakoid membrane protein complexes represents a valuable tool to monitor the dynamics of the photosynthetic machinery. Native-PAGE preserves the components and often also the conformation of the p... Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism [作者：Wang, B; Peng, YJ; Zhang, TL; Ding, JP,期刊：Biochemical Journal, 页码：215-225 , 文章类型： Article，,卷期：2011年439-2] GSTs (glutathione transferases) are a family of enzymes that primarily catalyse nucleophilic addition of the thiol of GSH (reduced glutathione) to a variety of hydrophobic electrophiles in the cellular detoxification of ... Reconstitution in liposomes of the functionally active human OCTN1 (SLC22A4) transporter overexpressed in Escherichia coli [作者：Pochini, L; Scalise, M; Galluccio, M; Amelio, L; Indiveri, C,期刊：Biochemical Journal, 页码：227-233 , 文章类型： Article，,卷期：2011年439-2] The hOCTN1 (human organic cation transporter 1) overexpressed in Escherichia coil and purified by Ni-chelating chromatography has been reconstituted in liposomes by detergent removal with a batch-wise procedure. The reco... Characterization of the dehydratase WcbK and the reductase WcaG involved in GDP-6-deoxy-manno-heptose biosynthesis in Campylobacter jejuni [作者：McCallum, M; Shaw, GS; Creuzenet, C,期刊：Biochemical Journal, 页码：235-248 , 文章类型： Article，,卷期：2011年439-2] The capsule of Campylobacter jejuni strain 81-176 comprises the unusual 6-deoxy-alpha-D-altro-heptose, whose biosynthesis and function are not known. In the present study, we characterized enzymes of the capsular cluster... Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8 [作者：Braun, D; Wirth, EK; Wohlgemuth, F; Reix, N; Klein, MO; Gruters, A; Kohrle, J; Schweizer, U,期刊：Biochemical Journal, 页码：249-255 , 文章类型： Article，,卷期：2011年439-2] LAT2 (system L amino acid transporter 2) is composed of the subunits Slc7a8/Lat2 and Slc3a2/4F2hc. This transporter is highly expressed along the basolateral membranes of absorptive epithelia in kidney and small intestin... Structural and mechanistic insight into the ferredoxin-mediated two-electron reduction of bilins [作者：Busch, AWU; Reijerse, EJ; Lubitz, W; Frankenberg-Dinkel, N; Hofmann, E,期刊：Biochemical Journal, 页码：257-264 , 文章类型： Article，,卷期：2011年439-2] PEB (phycoerythrobilin) is one of the major open-chain tetrapyrrole molecules found in cyanobacterial light-harvesting phycobiliproteins. In these organisms, two enzymes of the ferredoxin-dependent bilin reductase family... Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser(25) by AMP-activated protein kinase [作者：Roma-Mateo, C; Solaz-Fuster, MD; Gimeno-Alcaniz, JV; Dukhande, VV; Donderis, J; Worby, CA; Marina, A; Criado, O; Koller, A; De Cordoba, SR; Gentry, MS; Sanz, P,期刊：Biochemical Journal, 页码：265-275 , 文章类型： Article，,卷期：2011年439-2] Lafora progressive myoclonus epilepsy [LD (Lafora disease)] is a fatal, autosomal recessive neurodegenerative disorder caused by loss-of-function mutations in either the EPM2A gene, encoding the dual-specificity phosphat... 1(2)01810 is a novel type of glutamate transporter that is responsible for megamitochondrial formation [作者：Shim, MS; Kim, JY; Lee, KH; Jung, HK; Carlson, BA; Xu, XM; Hatfield, DL; Lee, BJ,期刊：Biochemical Journal, 页码：277-286 , 文章类型： Article，,卷期：2011年439-2] 1(2)01810 causes glutamine-,dependent megamitochondrial formation when it is overexpressed in Drosophila cells. In the present study, we elucidated the function of 1(2)01810 during megamitochondrial formation. The overex... mTORC2 targets AGC kinases through Sin1-dependent recruitment [作者：Cameron, AJM; Linch, MD; Saurin, AT; Escribano, C; Parker, PJ,期刊：Biochemical Journal, 页码：287-297 , 文章类型： Article，,卷期：2011年439-2] The protein kinase TOR (target of rapamycin) is a key regulator of cell growth and metabolism with significant clinical relevance. In mammals, TOR signals through two distinct multi-protein complexes, mTORC1 and mTORC2 (... Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins [作者：Rosales, KR; Singh, G; Wu, K; Chen, J; Janes, MR; Lilly, MB; Peralta, ER; Siskind, LJ; Bennett, MJ; Fruman, DA; Edinger, AL,期刊：Biochemical Journal, 页码：299-311 , 文章类型： Article，,卷期：2011年439-2] Cancer cells are hypersensitive to nutrient limitation because oncogenes constitutively drive glycolytic and TCA (tricarboxylic acid) cycle intermediates into biosynthetic pathways. As the anaplerotic reactions that repl... A phospholamban-tethered cardiac Ca(2+) pump reveals stoichiometry and dynamic interactions between the two proteins [作者：Chen, ZH,期刊：Biochemical Journal, 页码：313-319 , 文章类型： Article，,卷期：2011年439-2] To study PLB (phospholamban) inhibition of the cardiac Ca(2+) pump [SERCA2a (sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2a)], a fusion protein (SER-20G-PLB) was engineered by tethering SERCA2a with PLB through a 20... Varying dependency of periplasmic peptidylprolyl cis-trans isomerases in promoting Yersinia pseudotuberculosis stress tolerance and pathogenicity [作者：Obi, IR; Nordfelth, R; Francis, MS,期刊：Biochemical Journal, 页码：321-332 , 文章类型： Article，,卷期：2011年439-2] Periplasmic PPIases (peptidylprolyl cis-trans isomerases) catalyse the cis-trans isomerization of peptidyl-prolyl bonds, which is a rate-limiting step during protein folding. We demonstrate that the surA, ppiA, ppiD, fkp... Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1 [作者：Vandenberg, RJ; Handford, CA; Campbell, EM; Ryan, RM; Yool, AJ,期刊：Biochemical Journal, 页码：333-340 , 文章类型： Article，,卷期：2011年439-2] Glutamate transport is coupled to the co-transport of 3 Na(+) and 1 H(+) followed by the counter-transport of 1 K(+). In addition, glutamate and Na(+) binding to glutamate transporters generates an uncoupled anion conduc... Pathway analysis of NAD(+) metabolism [作者：de Figueiredo, LF; Gossmann, TI; Ziegler, M; Schuster, S,期刊：Biochemical Journal, 页码：341-348 , 文章类型： Article，,卷期：2011年439-2] NAD(+) is well known as a crucial cofactor in the redox balance of metabolism. Moreover, NAD(+) is degraded in ADP-ribosyl transfer reactions, which are important components of multitudinous signalling reactions. These i... Structure and properties of the Ca(2+)-binding CUB domain, a widespread ligand-recognition unit involved in major biological functions [作者：Gaboriaud, C; Gregory-Pauron, L; Teillet, F; Thielens, NM; Bally, I; Arlaud, GJ,期刊：Biochemical Journal, 页码：185-193 , 文章类型： Review，,卷期：2011年439-2] CUB domains are 110-residue protein motifs exhibiting a beta-sandwich fold and mediating protein-protein interactions in various extracellular proteins. Recent X-ray structural and mutagenesis studies have led to the ide...