- Residues in the Hendra Virus Fusion Protein Transmembrane Domain Are Critical for Endocytic Recycling
[作者:Popa, A; Carter, JR; Smith, SE; Hellman, L; Fried, MG; Dutch, RE,期刊:Journal of virology, 页码:3014-3026 , 文章类型: Article,,卷期:2012年86-6]
- Hendra virus is a highly pathogenic paramyxovirus classified as a biosafety level four agent. The fusion (F) protein of Hendra virus is critical for promoting viral entry and cell-to-cell fusion. To be fusogenically acti...
- Wild-Type Measles Virus with the Hemagglutinin Protein of the Edmonston Vaccine Strain Retains Wild-Type Tropism in Macaques
[作者:Takeuchi, K; Nagata, N; Kato, S; Ami, Y; Suzaki, Y; Suzuki, T; Sato, Y; Tsunetsugu-Yokota, Y; Mori, K; Nguyen, NV; Kimura, H; Nagata, K,期刊:Journal of virology, 页码:3027-3037 , 文章类型: Article,,卷期:2012年86-6]
- A major difference between vaccine and wild-type strains of measles virus (MV) in vitro is the wider cell specificity of vaccine strains, resulting from the receptor usage of the hemagglutinin (H) protein. Wild-type H pr...
- Characterization of the RNA Silencing Suppression Activity of the Ebola Virus VP35 Protein in Plants and Mammalian Cells
[作者:Zhu, YL; Cherukuri, NC; Jackel, JN; Wu, ZT; Crary, M; Buckley, KJ; Bisaro, DM; Parris, DS,期刊:Journal of virology, 页码:3038-3049 , 文章类型: Article,,卷期:2012年86-6]
- Ebola virus (EBOV) causes a lethal hemorrhagic fever for which there is no approved effective treatment or prevention strategy. EBOV VP35 is a virulence factor that blocks innate antiviral host responses, including the i...
- Genome-Wide Networks of Amino Acid Covariances Are Common among Viruses
[作者:Donlin, MJ; Szeto, B; Gohara, DW; Aurora, R; Tavis, JE,期刊:Journal of virology, 页码:3050-3063 , 文章类型: Article,,卷期:2012年86-6]
- Coordinated variation among positions in amino acid sequence alignments can reveal genetic dependencies at noncontiguous positions, but methods to assess these interactions are incompletely developed. Previously, we foun...
- Vesicular Stomatitis Virus as an Oncolytic Agent against Pancreatic Ductal Adenocarcinoma
[作者:Murphy, AM; Besmer, DM; Moerdyk-Schauwecker, M; Moestl, N; Ornelles, DA; Mukherjee, P; Grdzelishvili, VZ,期刊:Journal of virology, 页码:3073-3087 , 文章类型: Article,,卷期:2012年86-6]
- Vesicular stomatitis virus (VSV) is a promising oncolytic agent against a variety of cancers. However, it has never been tested in any pancreatic cancer model. Pancreatic ductal adenocarcinoma (PDA) is the most common an...
- Epstein-Barr Virus Downregulates MicroRNA 203 through the Oncoprotein Latent Membrane Protein 1: a Contribution to Increased Tumor Incidence in Epithelial Cells
[作者:Yu, HB; Lu, JH; Zuo, LL; Yan, QJ; Yu, ZY; Li, XY; Huang, J; Zhao, L; Tang, HL; Luo, ZH; Liao, QJ; Zeng, ZY; Zhang, JY; Li, GY,期刊:Journal of virology, 页码:3088-3099 , 文章类型: Article,,卷期:2012年86-6]
- The Epstein-Barr virus (EBV) is highly associated with nasopharyngeal carcinoma (NPC), and it regulates some microRNAs (miRNAs) that are involved in the development of cancer. The role of EBV in the deregulation of cellu...
- Mutating Conserved Cysteines in the Alphavirus E2 Glycoprotein Causes Virus-Specific Assembly Defects
[作者:Snyder, AJ; Sokoloski, KJ; Mukhopadhyay, S,期刊:Journal of virology, 页码:3100-3111 , 文章类型: Article,,卷期:2012年86-6]
- There are 80 trimeric, glycoprotein spikes that cover the surface of an alphavirus particle. The spikes, which are composed of three E2 and E1 glycoprotein heterodimers, are responsible for receptor binding and mediating...
- Mapping of Chikungunya Virus Interactions with Host Proteins Identified nsP2 as a Highly Connected Viral Component
[作者:Bourai, M; Lucas-Hourani, M; Gad, HH; Drosten, C; Jacob, Y; Tafforeau, L; Cassonnet, P; Jones, LM; Judith, D; Couderc, T; Lecuit, M; Andre, P; Kummerer, BM; Lotteau, V; Despres, P; Tangy, F; Vidalain, PO,期刊:Journal of virology, 页码:3121-3134 , 文章类型: Article,,卷期:2012年86-6]
- Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has been responsible for an epidemic outbreak of unprecedented magnitude in recent years. Since then, significant efforts have been made to better under...
- Simian Virus 40 Strains with Novel Properties Generated by Replacing the Viral Enhancer with Synthetic Oligonucleotides
[作者:Gunther, V; Strassen, T; Lindert, U; Dagani, P; Waldvogel, D; Georgiev, O; Schaffner, W; Bethge, T,期刊:Journal of virology, 页码:3135-3142 , 文章类型: Article,,卷期:2012年86-6]
- Typical enhancers of viral or cellular genes are approximately 100 to 400 bp long and contain several transcription factor binding sites. Previously, we have shown that simian virus 40 (SV40) genomic DNA that lacks its o...
- Varicella-Zoster Virus ORF12 Protein Triggers Phosphorylation of ERK1/2 and Inhibits Apoptosis
[作者:Liu, XQ; Li, QX; Dowdell, K; Fischer, ER; Cohen, JI,期刊:Journal of virology, 页码:3143-3151 , 文章类型: Article,,卷期:2012年86-6]
- Mitogen-activated protein kinases (MAPKs) are a family of serine-threonine protein kinases involved in many cellular processes, including cell proliferation, differentiation, inflammation, and cell death. Activation of s...
- Restricted Replication of Xenotropic Murine Leukemia Virus-Related Virus in Pigtailed Macaques
[作者:Del Prete, GQ; Kearney, MF; Spindler, J; Wiegand, A; Chertova, E; Roser, JD; Estes, JD; Hao, XP; Trubey, CM; Lara, A; Lee, K; Chaipan, C; Bess, JW; Nagashima, K; Keele, BF; Macallister, R; Smedley, J; Pathak, VK; KewalRamani, VN; Coffin, JM; Lifson, JD,期刊:Journal of virology, 页码:3152-3166 , 文章类型: Article,,卷期:2012年86-6]
- Although xenotropic murine leukemia virus-related virus (XMRV) has been previously linked to prostate cancer and myalgic encephalomyelitis/chronic fatigue syndrome, recent data indicate that results interpreted as eviden...
- Adenovirus E4orf3 Targets Transcriptional Intermediary Factor 1 gamma for Proteasome-Dependent Degradation during Infection
[作者:Forrester, NA; Patel, RN; Speiseder, T; Groitl, P; Sedgwick, GG; Shimwell, NJ; Seed, RI; Catnaigh, PO; McCabe, CJ; Stewart, GS; Dobner, T; Grand, RJA; Martin, A; Turnell, AS,期刊:Journal of virology, 页码:3167-3179 , 文章类型: Article,,卷期:2012年86-6]
- The ability of adenovirus early region proteins, E1B-55K and E4orf6, to usurp control of cellular ubiquitin ligases and target proteins for proteasome-dependent degradation during infection is well established. Here we s...
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