- Brodalumab, an Anti-Interleukin-17-Receptor Antibody for Psoriasis
[作者:Papp, KA; Leonardi, C; Menter, A; Ortonne, JP; Krueger, JG; Kricorian, G; Aras, G; Li, J; Russell, CB; Thompson, EHZ; Baumgartner, S,期刊:New England Journal of Medicine, 页码:1181-1189 , 文章类型: Article,,卷期:2012年366-13]
- Background In this phase 2, randomized, double-blind, placebo-controlled, dose-ranging study, we assessed the efficacy and safety of brodalumab (AMG 827), a human anti-interleukin-17-receptor monoclonal antibody, for the...
- Lifestyle Change and Mobility in Obese Adults with Type 2 Diabetes
[作者:Rejeski, WJ; Ip, EH; Bertoni, AG; Bray, GA; Evans, G; Gregg, EW; Zhang, Q,期刊:New England Journal of Medicine, 页码:1209-1217 , 文章类型: Article,,卷期:2012年366-13]
- BACKGROUND Adults with type 2 diabetes mellitus often have limitations in mobility that increase with age. An intensive lifestyle intervention that produces weight loss and improves fitness could slow the loss of mobilit...
- Case 10-2012: A 16-Year-Old Boy with Epigastric Pain and a Mediastinal Mass Esophageal duplication cyst with chronic inflammation, necrosis, and calcification.
[作者:Kelleher, CM; Forcione, DG; Gee, MS; Mino-Kenudson, M,期刊:New England Journal of Medicine, 页码:1242-1250 , 文章类型: Article,,卷期:2012年366-13]
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- Anti-Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis
[作者:Leonardi, C; Matheson, R; Zachariae, C; Cameron, G; Li, L; Edson-Heredia, E; Braun, D; Banerjee, S,期刊:New England Journal of Medicine, 页码:1190-1199 , 文章类型: Article,,卷期:2012年366-13]
- BACKGROUND Type 17 helper T cells have been suggested to play a pathological role in psoriasis. They secrete several proinflammatory cytokines, including interleukin-17A (also known as interleukin-17). We evaluated the s...
- HLA Class II Locus and Susceptibility to Podoconiosis
[作者:Ayele, FT; Adeyemo, A; Finan, C; Hailu, E; Sinnott, P; Burlinson, ND; Aseffa, A; Rotimi, CN; Newport, MJ; Davey, G,期刊:New England Journal of Medicine, 页码:1200-1208 , 文章类型: Article,,卷期:2012年366-13]
- BACKGROUND Podoconiosis is a tropical lymphedema resulting from long-term barefoot exposure to red-clay soil derived from volcanic rock. The World Health Organization recently designated it as a neglected tropical diseas...
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