- Glyceollin I, a Novel Antiestrogenic Phytoalexin Isolated from Activated Soy
[作者：Zimmermann, MC; Tilghman, SL; Boue, SM; Salvo, VA; Elliott, S; Williams, KY; Skripnikova, EV; Ashe, H; Payton-Stewart, F; Vanhoy-Rhodes, L; Fonseca, JP; Corbitt, C; Collins-Burow, BM; Howell, MH; Lacey, M; Shih, BY; Carter-Wientjes, C; Cleveland, TE; McLachlan, JA; Wiese, TE; Beckman, BS; Burow, ME,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：35-45 , 文章类型： Article，,卷期：2010年332-1]
- Glyceollins, a group of novel phytoalexins isolated from activated soy, have recently been demonstrated to be novel antiestrogens that bind to the estrogen receptor (ER) and inhibit estrogen-induced tumor progression. Ou...
- Hepatobiliary Disposition of Troglitazone and Metabolites in Rat and Human Sandwich-Cultured Hepatocytes: Use of Monte Carlo Simulations to Assess the Impact of Changes in Biliary Excretion on Troglitazone Sulfate Accumulation
[作者：Lee, JK; Marion, TL; Abe, K; Lim, CW; Pollock, GM; Brouwer, KLR,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：26-34 , 文章类型： Article，,卷期：2010年332-1]
- This study examined the hepatobiliary disposition of troglitazone (TGZ) and metabolites [TGZ sulfate (TS), TGZ glucuronide (TG), and TGZ quinone (TQ)] over time in rat and human sandwich-cultured hepatocytes (SCH). Cells...
- Inhibition of Phosphoinositide 3-Kinase Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice
[作者：Peng, XD; Wu, XH; Chen, LJ; Wang, ZL; Hu, XH; Song, LF; He, CM; Luo, YF; Chen, ZZ; Jin, K; Lin, HG; Li, XL; Wang, YS; Wei, YQ,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：46-56 , 文章类型： Article，,卷期：2010年332-1]
- The critical role of phosphoinositide 3-kinase gamma (PI3K gamma) in inflammatory cell activation and recruitment makes it an attractive target for immunomodulatory therapy. 5-Quinoxilin-6-methylene-1,3-thiazolidine-2,4-...
- 20-Hydroxy-5,8,11,14-eicosatetraenoic Acid Mediates Endothelial Dysfunction via I kappa B Kinase-Dependent Endothelial Nitric-Oxide Synthase Uncoupling
[作者：Cheng, J; Wu, CC; Gotlinger, KH; Zhang, F; Falck, JR; Narsimhaswamy, D; Schwartzman, ML,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：57-65 , 文章类型： Article，,卷期：2010年332-1]
- Endothelial dysfunction and activation occur in the vasculature and are believed to contribute to the pathogenesis of cardiovascular diseases. We have shown that 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), a cy...
- Benzodiazepine Binding Site Occupancy by the Novel GABA(A) Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans
[作者：Atack, JR; Wong, DF; Fryer, TD; Ryan, C; Sanabria, S; Zhou, Y; Dannals, RF; Eng, WS; Gibson, RE; Burns, HD; Vega, JM; Vessy, L; Scott-Stevens, P; Beech, JS; Baron, JC; Sohal, B; Schrag, ML; Aigbirhio, FI; McKernan, RM; Hargreaves, RJ,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：17-25 , 文章类型： Article，,卷期：2010年332-1]
- The GABA(A) receptor alpha 2/alpha 3 subtype-selective compound 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023; also known as MK-0777) is a triaz...
- Reducing Abuse Liability of GABA(A)/Benzodiazepine Ligands via Selective Partial Agonist Efficacy at alpha(1) and alpha(2/3) Subtypes
[作者：Ator, NA; Atack, JR; Hargreaves, RJ; Burns, HD; Dawson, GR,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：4-16 , 文章类型： Article，,卷期：2010年332-1]
- Abuse-liability-related effects of subtype-selective GABA(A) modulators were explored relative to the prototypic benzodiazepine lorazepam. 7-Cyclobutyl-6-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,4-triazolo[4,...
- A Conserved Motif in the Membrane Proximal C-Terminal Tail of Human Muscarinic M-1 Acetylcholine Receptors Affects Plasma Membrane Expression
[作者：Sawyer, GW; Ehlert, FJ; Shults, CA,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：76-86 , 文章类型： Article，,卷期：2010年332-1]
- We investigated the functional role of a conserved motif, F(x)(6)LL, in the membrane proximal C-tail of the human muscarinic M-1 (hM(1)) receptor. By use of site-directed mutagenesis, several different point mutations we...
- Cyanide-Induced Apoptosis of Dopaminergic Cells Is Promoted by BNIP3 and Bax Modulation of Endoplasmic Reticulum-Mitochondrial Ca2+ Levels
[作者：Zhang, L; Li, L; Leavesley, HW; Zhang, X; Borowitz, JL; Isom, GE,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：97-105 , 文章类型： Article，,卷期：2010年332-1]
- Cyanide is a potent neurotoxicant that can produce dopaminergic neuronal death in the substantia nigra and is associated with a Parkinson-like syndrome. In this study involvement of Bcl-2/adenovirus E1B 19-kDa interactin...
- Sublethal Doses of an Anti-erbB2 Antibody Leads to Death by Apoptosis in Cardiomyocytes Sensitized by Low Prosenescent Doses of Epirubicin: The Protective Role of Dexrazoxane
[作者：Spallarossa, P; Altieri, P; Pronzato, P; Aloi, C; Ghigliotti, G; Barsotti, A; Brunelli, C,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：87-96 , 文章类型： Article，,卷期：2010年332-1]
- The cardiotoxic synergism resulting from the sequential treatment with anthracyclines and trastuzumab has been attributed to the trastuzumab-induced loss of the erbB2-related functions that serve as a salvage pathway aga...
- Angiotensin II-Induced Migration of Vascular Smooth Muscle Cells Is Mediated by p38 Mitogen-Activated Protein Kinase-Activated c-Src Through Spleen Tyrosine Kinase and Epidermal Growth Factor Receptor Transactivation
[作者：Mugabe, BE; Yaghini, FA; Song, CY; Buharalioglu, CK; Waters, CM; Malik, KU,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：116-124 , 文章类型： Article，,卷期：2010年332-1]
- Angiotensin II (Ang II) stimulates protein synthesis by activating spleen tyrosine kinase (Syk) and DNA synthesis through epidermal growth factor receptor (EGFR) transactivation in vascular smooth muscle cells (VSMCs). T...
- A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor (CAR) 1 to the Xenobiotic-Sensitive Splicing Variant CAR3
[作者：Chen, T; Tompkins, LM; Li, LH; Li, HS; Kim, G; Zheng, YX; Wang, HB,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：106-115 , 文章类型： Article，,卷期：2010年332-1]
- The constitutive androstane receptor (CAR) is constitutively activated in immortalized cell lines independent of xenobiotic stimuli. This feature of CAR has limited its use as a sensor for xenobiotic-induced expression o...
- Antagonism of Aryl Hydrocarbon Receptor Signaling by 6,2 ',4 '-Trimethoxyflavone
[作者：Murray, IA; Flaveny, CA; DiNatale, BC; Chairo, CR; Schroeder, JC; Kusnadi, A; Perdew, GH,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：135-144 , 文章类型： Article，,卷期：2010年332-1]
- The aryl hydrocarbon receptor (AHR) is regarded as an important homeostatic transcriptional regulator within physiological and pathophysiological processes, including xenobiotic metabolism, endocrine function, immunity, ...
- Early Intervention of Tyrosine Nitration Prevents Vaso-Obliteration and Neovascularization in Ischemic Retinopathy
[作者：Abdelsaid, MA; Pillai, BA; Matragoon, S; Prakash, R; Al-Shabrawey, M; El-Remessy, AB,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：125-134 , 文章类型： Article，,卷期：2010年332-1]
- Diabetic retinopathy and retinopathy of prematurity are blinding disorders that follow a pathological pattern of ischemic retinopathy and affect premature infants and working-age adults. Yet, the treatment options are li...
- Predominance of Adenosine Excitatory over Inhibitory Effects on Transmission at the Neuromuscular Junction of Infant Rats
[作者：Pousinha, PA; Correia, AM; Sebastiao, AM; Ribeiro, JA,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：153-163 , 文章类型： Article，,卷期：2010年332-1]
- Adenosine-induced modulation of neuromuscular transmission in young (3-4-week-old) rats was evaluated. Inhibition of adenosine kinase with iodotubercidin (ITU; 10 mu M), which is known to induce adenosine release, enhanc...
- Nicotinamide Glycolates Antagonize CXCR2 Activity through an Intracellular Mechanism
[作者：Maeda, DY; Quinn, MT; Schepetkin, IA; Kirpotina, LN; Zebala, JA,期刊：Journal of Pharmacology and Experimental Therapeutics, 页码：145-152 , 文章类型： Article，,卷期：2010年332-1]
- The chemokine receptors CXCR1/2 are involved in a variety of inflammatory diseases, including chronic obstructive pulmonary disease. Several classes of allosteric small-molecule CXCR1/2 antagonists have been developed. T...
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