- Sazetidine-A, a Selective alpha 4 beta 2 Nicotinic Receptor Desensitizing Agent and Partial Agonist, Reduces Nicotine Self-Administration in Rats
[作者:Levin, ED; Rezvani, AH; Xiao, YX; Slade, S; Cauley, M; Wells, C; Hampton, D; Petro, A; Rose, JE; Brown, ML; Paige, MA; McDowell, BE; Kellar, KJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:933-939 , 文章类型: Article,,卷期:2010年332-3]
- Adequate treatment of tobacco addiction remains problematic. Part of the problem with treatment is a poor understanding of the pharmacologic aspects of nicotine contributing to addiction. In addition to activating nicoti...
- A Silybin-Phospholipid Complex Prevents Mitochondrial Dysfunction in a Rodent Model of Nonalcoholic Steatohepatitis
[作者:Serviddio, G; Bellanti, F; Giudetti, AM; Gnoni, GV; Petrella, A; Tamborra, R; Romano, AD; Rollo, T; Vendemiale, G; Altomare, E,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:922-932 , 文章类型: Article,,卷期:2010年332-3]
- Mitochondrial dysfunction and oxidative stress are determinant events in the pathogenesis of nonalcoholic steatohepatitis. Silybin has shown antioxidant, anti-inflammatory, and antifibrotic effects in chronic liver disea...
- Pharmacogenomic Approach Reveals a Role for the x(c)(-) Cystine/Glutamate Antiporter in Growth and Celastrol Resistance of Glioma Cell Lines
[作者:Pham, AN; Blower, PE; Alvarado, O; Ravula, R; Gout, PW; Huang, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:949-958 , 文章类型: Article,,卷期:2010年332-3]
- The x(c)(-) cystine/glutamate antiporter has been implicated in GSH-based chemoresistance because it mediates cellular uptake of cystine/cysteine for sustenance of intracellular GSH levels. Celastrol, isolated from a Chi...
- Extracellular Signal-Regulated Kinase 1/2 and c-Jun NH2-Terminal Kinase, through Nuclear Factor-kappa B and Activator Protein-1, Contribute to Caerulein-Induced Expression of Substance P and Neurokinin-1 Receptors in Pancreatic Acinar Cells
[作者:Koh, YH; Tamizhselvi, R; Bhatia, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:940-948 , 文章类型: Article,,卷期:2010年332-3]
- The neuropeptide substance P (SP) has emerged to be an important proinflammatory mediator in acute pancreatitis (AP). The presence of substance P and its receptor, neurokinin-1 receptor (NK1R) has been shown in the pancr...
- Attenuation of Cocaine's Reinforcing and Discriminative Stimulus Effects via Muscarinic M-1 Acetylcholine Receptor Stimulation
[作者:Thomsen, M; Conn, PJ; Lindsley, C; Wess, J; Boon, JY; Fulton, BS; Fink-Jensen, A; Caine, SB,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:959-969 , 文章类型: Article,,卷期:2010年332-3]
- Muscarinic cholinergic receptors modulate dopaminergic function in brain pathways thought to mediate cocaine's abuse-related effects. Here, we sought to confirm and extend in the mouse species findings that nonselective ...
- Antillatoxin, a Novel Lipopeptide, Enhances Neurite Outgrowth in Immature Cerebrocortical Neurons through Activation of Voltage-Gated Sodium Channels
[作者:Jabba, SV; Prakash, A; Dravid, SM; Gerwick, WH; Murray, TF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:698-709 , 文章类型: Article,,卷期:2010年332-3]
- Antillatoxin (ATX) is a structurally novel lipopeptide that activates voltage-gated sodium channels (VGSC) leading to sodium influx in cerebellar granule neurons and cerebrocortical neurons 8 to 9 days in vitro (Li et al...
- No Evidence for Functional Selectivity of Proxyfan at the Human Histamine H-3 Receptor Coupled to Defined G(i)/G(o) Protein Heterotrimers
[作者:Schnell, D; Burleigh, K; Trick, J; Seifert, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:996-1005 , 文章类型: Article,,卷期:2010年332-3]
- Numerous structurally diverse ligands were developed to target the human histamine H-3 receptor (hH(3)R), a presynaptic G(i)/G(o)-coupled auto- and heteroreceptor. Proxyfan was identified to be functionally selective, wi...
- Targeting of a Mutant Plasminogen Activator to Circulating Red Blood Cells for Prophylactic Fibrinolysis
[作者:Zaitzev, S; Spitzer, D; Murciano, JC; Ding, BS; Tliba, S; Kowalska, MA; Bdeir, K; Kuo, A; Stepanova, V; Atkinson, JP; Poncz, M; Cines, DB; Muzykantov, VR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1022-1031 , 文章类型: Article,,卷期:2010年332-3]
- Chemical coupling to carrier red blood cells (RBCs) converts tissue type plasminogen activator (tPA) from a problematic therapeutic into a safe agent for thromboprophylaxis. The goal of this study was to develop a more c...
- Metabolic Fate of Lactoferricin-Based Antimicrobial Peptides: Effect of Truncation and Incorporation of Amino Acid Analogs on the In Vitro Metabolic Stability
[作者:Svenson, J; Vergote, V; Karstad, R; Burvenich, C; Svendsen, JS; De Spiegeleer, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1032-1039 , 文章类型: Article,,卷期:2010年332-3]
- A series of promising truncated antibacterial tripeptides derived from lactoferricin has been prepared, and their in vitro metabolic stability in the main metabolic compartments, plasma, liver, kidney, stomach, duodenum,...
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