个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Rapalogs in viral cancers [作者：Dittmer, DP; Bhatt, AP; Damania, B,期刊：Expert opinion on investigational drugs, 页码：135-138 , 文章类型： Editorial Material，,卷期：2012年21-2] At present, 150 clinical trials are registered with the National Cancer Institute, which investigate the efficacy of inhibitors of the PI3K/Akt/mTOR pathway against multiple cancers. Efficacy varies not so much with drug... PDGF receptor blocker for pulmonary hypertension: a new agent in therapeutic arsenal [作者：Mathew, R,期刊：Expert opinion on investigational drugs, 页码：139-142 , 文章类型： Editorial Material，,卷期：2012年21-2] Drugs in preclinical and early-stage clinical development for pancreatic cancer [作者：Asuthkar, S; Rao, JS; Gondi, CS,期刊：Expert opinion on investigational drugs, 页码：143-152 , 文章类型： Review，,卷期：2012年21-2] Introduction: Pancreatic cancer (PC) is the fourth leading cause of cancer-related deaths in the US and Europe, and the lethality of this cancer is demonstrated by the fact that the annual incidences are approximately eq... New pharmacological avenues for the treatment of L-DOPA-induced dyskinesias in Parkinson's disease: targeting glutamate and adenosine receptors [作者：Blandini, F; Armentero, MT,期刊：Expert opinion on investigational drugs, 页码：153-168 , 文章类型： Review，,卷期：2012年21-2] Introduction: Parkinson's disease (PD) therapy is still centered on the use of L-3,4-dihydroxyphenylalanine (L-DOPA), which is hampered by numerous side effects, including abnormal involuntary movements known as L-DOPA-i... Glial modulators: a novel pharmacological approach to altering the behavioral effects of abused substances [作者：Cooper, ZD; Jones, JD; Comer, SD,期刊：Expert opinion on investigational drugs, 页码：169-178 , 文章类型： Review，,卷期：2012年21-2] Introduction: Commonly abused drugs including opioids, stimulants and alcohol activate glia cells, an effect that has been identified across species. Glia, specifically astrocytes and microglia, have been shown to contri... New agents for acute myeloid leukemia: is it time for targeted therapies? [作者：Ferrara, F,期刊：Expert opinion on investigational drugs, 页码：179-189 , 文章类型： Review，,卷期：2012年21-2] Introduction: The prognosis of acute myeloid leukemia (AML) is improved in the last two decades, even though induction and consolidation chemotherapy has not involved new drugs. The more effective use of well-known agent... Targeting the subtypes of breast cancer: rethinking investigational drugs [作者：Curigliano, G; Locatelli, M; Fumagalli, L; Brollo, J; Munzone, E; Nole, F; Criscitiello, C; Goldhirsch, A,期刊：Expert opinion on investigational drugs, 页码：191-204 , 文章类型： Review，,卷期：2012年21-2] Introduction: The choice of adjuvant treatments for women with breast cancer is based on several features that take into account the heterogeneity of the disease. Questions raised during the decision process include the ... Brentuximab Vedotin (SGN-35), an antibody-drug conjugate for the treatment of CD30-positive malignancies [作者：Gualberto, A,期刊：Expert opinion on investigational drugs, 页码：205-216 , 文章类型： Review，,卷期：2012年21-2] Introduction: CD30-positive hematological malignancies are potentially curable with frontline combination chemotherapy regimens; however, those patients who relapse or are refractory to initial therapies have less favora... Pazopanib for the treatment of breast cancer [作者：Amiri-Kordestani, L; Tan, AR; Swain, SM,期刊：Expert opinion on investigational drugs, 页码：217-225 , 文章类型： Editorial Material，,卷期：2012年21-2] Introduction: Several clinical trials have shown clinical benefit of angiogenesis inhibitors in the treatment of solid tumors. Pazopanib is a multitargeted tyrosine kinase inhibitor that is currently approved for the tre... MDV3100 for the treatment of prostate cancer [作者：Mukherji, D; Pezaro, CJ; De-Bono, JS,期刊：Expert opinion on investigational drugs, 页码：227-233 , 文章类型： Editorial Material，,卷期：2012年21-2] Introduction: MDV3100 is a rationally designed androgen receptor antagonist, which has recently been shown to improve survival in men with metastatic castration-resistant prostate cancer previously treated with docetaxel... Misoprostol for the prevention and treatment of postpartum hemorrhage [作者：Sheldon, WR; Blum, J; Durocher, J; Winikoff, B,期刊：Expert opinion on investigational drugs, 页码：235-250 , 文章类型： Editorial Material，,卷期：2012年21-2] Introduction: Uterotonic drugs are recommended for the prevention and treatment of postpartum hemorrhage (PPH), and oxytocin is considered the gold standard for both indications due to its established efficacy and safety... Apaziquone as an intravesical therapeutic agent for urothelial non-muscle-invasive bladder cancer [作者：Yutkin, V; Chin, J,期刊：Expert opinion on investigational drugs, 页码：251-260 , 文章类型： Editorial Material，,卷期：2012年21-2] Introduction: Urothelial carcinoma of the bladder is a disease prone to recurrence. A new cytotoxic drug, apaziquone, is an analog of mitomycin C. Given via intravesical instillations it has the ability to specifically t...