Expert opinion on investigational drugs————————个性化文献订阅—

JAK2 inhibition for the treatment of hematologic and solid malignancies
[作者：Harry, BL; Eckhardt, SG; Jimeno, A,期刊：Expert opinion on investigational drugs, 页码：637-655 , 文章类型： Review，,卷期：2012年21-5]
Introduction: Mutations in Janus kinase 2 (JAK2), and in particular JAK2 V617F, are common in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). In the past several years, JAK2 inhibitors have been rap...

Investigational ABC transporter inhibitors
[作者：Falasca, M; Linton, KJ,期刊：Expert opinion on investigational drugs, 页码：657-666 , 文章类型： Review，,卷期：2012年21-5]
Introduction: Multidrug resistance (MDR) is the main cause of failure in cancer therapy. One mechanism responsible for MDR is the active efflux of drugs by ATP-binding cassette (ABC) transporters. Several agents have bee...

Inhibition of pre-protein convertase serine kexin-9 (PCSK-9) as a treatment for hyperlipidaemia
[作者：Wierzbicki, AS; Hardman, TC; Viljoen, A,期刊：Expert opinion on investigational drugs, 页码：667-676 , 文章类型： Review，,卷期：2012年21-5]
Introduction: Pre-protein convertase subtilisin kexin (PCSK)-9 is a newly discovered protein involved in intracellular and extracellular regulation of low-density lipoprotein receptor (LDLR) expression. Autosomal dominan...

New frontiers in female contraception (and male condoms): 2012
[作者：Nelson, AL,期刊：Expert opinion on investigational drugs, 页码：677-693 , 文章类型： Review，,卷期：2012年21-5]
Introduction: Contraception made profound contributions to women's health in the twentieth century and has the potential to help achieve each of the eight millennium development goals in the twenty-first. However, contra...

A drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infection
[作者：Gengiah, TN; Baxter, C; Mansoor, LE; Kharsany, ABM; Karim, SSA,期刊：Expert opinion on investigational drugs, 页码：695-715 , 文章类型： Article，,卷期：2012年21-5]
Introduction: More than a million people acquire HIV infection annually. Pre-exposure prophylaxis (PrEP) using antiretrovirals is currently being investigated for HIV prevention. Oral and topical formulations of tenofovi...

ENMD-2076 for hematological malignancies
[作者：How, J; Yee, K,期刊：Expert opinion on investigational drugs, 页码：717-732 , 文章类型： Article，,卷期：2012年21-5]
Introduction: Aurora kinases are key regulators of mitosis and inhibition of Aurora kinase activity is a rational therapeutic strategy in the treatment of solid tumors and hematological malignancies.Areas covered: This p...

Panobinostat for the treatment of multiple myeloma
[作者：Neri, P; Bahlis, NJ; Lonial, S,期刊：Expert opinion on investigational drugs, 页码：733-747 , 文章类型： Article，,卷期：2012年21-5]
Introduction: Multiple myeloma (MM) is a B-cell malignancy characterized by proliferation of monoclonal plasma cells in the bone marrow. Although new therapeutic options have been introduced and response rates have impro...

Glufosfamide: can we improve the process of anticancer agent development?
[作者：Lacombe, D,期刊：Expert opinion on investigational drugs, 页码：749-754 , 文章类型： Article，,卷期：2012年21-5]
Introduction: Drug development is a complex and risky enterprise. Clinical development must be a thoroughly paced process sequenced by clinical and developmental questions logically ordered. Drug development parameters a...

EC145: a novel targeted agent for adenocarcinoma of the lung
[作者：Pribble, P; Edelman, MJ,期刊：Expert opinion on investigational drugs, 页码：755-761 , 文章类型： Article，,卷期：2012年21-5]
Introduction: EC145 is a folate receptor (FR)-targeted vinca alkaloid conjugate currently under development as an anticancer agent. The FR is overexpressed on a number of major malignancies including adenocarcinoma of th...

Sulfasalazine for brain cancer fits
[作者：Sontheimer, H; Bridges, RJ,期刊：Expert opinion on investigational drugs, 页码：575-578 , 文章类型： Editorial Material，,卷期：2012年21-5]
Recent research has identified an important role for a cystine-glutamate antiporter (system Xc) in the biology of malignant brain tumors. This transporter is effectively inhibited by sulfasalazine, a drug widely used to ...

Norgestrel may be a potential therapy for retinal degenerations
[作者：Doonan, F; Cotter, TG,期刊：Expert opinion on investigational drugs, 页码：579-581 , 文章类型： Editorial Material，,卷期：2012年21-5]
Retinal degenerations cover a broad spectrum of diseases, retinitis pigmentosa being the most common inherited retinal degeneration. It remains an untreatable disorder, partly owing to its genetic complexity and variabil...

Targeting of polo-like kinases and their cross talk with Aurora kinases - possible therapeutic strategies in human acute myeloid leukemia?
[作者：Tsykunova, G; Reikvam, H; Ahmed, AB; Nepstad, I; Gjertsen, BT; Bruserud, O,期刊：Expert opinion on investigational drugs, 页码：587-603 , 文章类型： Review，,卷期：2012年21-5]
Introduction: Five human polo-like kinases (PLKs) have been identified, and PLK1 - 4 seem to interact with Aurora kinases and act as cell cycle regulators in both normal and malignant human cells.Areas covered: The prese...

Is there a world beyond bevacizumab in targeting angiogenesis in glioblastoma?
[作者：Seystahl, K; Weller, M,期刊：Expert opinion on investigational drugs, 页码：605-617 , 文章类型： Review，,卷期：2012年21-5]
Introduction: Antiangiogenic approaches are currently the dominating experimental therapeutic strategy in glioblastoma. First enthusiasm was provoked by promising radiological response rates and an apparent clinical bene...

Recent advances on structural modifications of benzothiazoles and their conjugate systems as potential chemotherapeutics
[作者：Ahmed, K; Venkata, SYV; Mohammed, NAK; Sultana, F; Methuku, KR,期刊：Expert opinion on investigational drugs, 页码：619-635 , 文章类型： Review，,卷期：2012年21-5]
Introduction: Benzothiazole scaffold comprises a bicyclic ring system and is known to exhibit a wide range of biological properties including antimicrobial and anticancer activities. Benzothiazole derivatives have long b...