- Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors
[作者:HOU YAPING; SUN JUAN; PANG ZHONGHUA; LV PENGCHENG; LI DONGDONG; YAN LI; ZHANG HONGJIA; ZHENG EMILY XI; ZHAO JING; ZHU HAILIANG,期刊:Bioorganic & Medicinal Chemistry, 页码:5948-5954 , 文章类型: Article,,卷期:2011年19-20]
- A series of 1,2,4-triazole derivatives containing 1,4-benzodioxan (5a-5q) have been designed, synthesized, structurally determined, and their biological activities were evaluated as potential MetAP2 inhibitors. All the s...
- Pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines and their tricyclic derivatives as corticotropin-releasing factor 1 (CRF(1)) receptor antagonists
[作者:SAITO TETSUJI; OBITSU TETSUO; MINAMOTO CHIAKI; SUGIURA TSUNEYUKI; MATSUMURA NAOYA; UENO SONOKO; KISHI AKIHIRO; KATSUMATA SEISHI; NAKAI HISAO; TODA MASAAKI,期刊:Bioorganic & Medicinal Chemistry, 页码:5955-5966 , 文章类型: Article,,卷期:2011年19-20]
- To identify structurally novel CRF1 receptor antagonists, a series of bicyclic core antagonists, pyrazolo [1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines, imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a][1,3,5]triazines were...
- Design, synthesis and biological evaluation of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as aminopeptidase N/CD13 inhibitors
[作者:ZHANG XIAOPAN; ZHANG JIAN; ZHANG LEI; FENG JINGHONG; XU YINGYING; YUAN YUMEI; FANG HAO; XU WENFANG,期刊:Bioorganic & Medicinal Chemistry, 页码:6015-6025 , 文章类型: Article,,卷期:2011年19-20]
- A series of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives were designed, synthesized and assayed for their activities against aminopeptidase N (APN/CD13) and MMP-2. The results showed that most compo...
- Synthesis and biological evaluation of phenstatin metabolites
[作者:GHINET ALINA; RIGO BENOIT; HENICHART JEANPIERRE; LE BROCRYCKEWAERT DELPHINE; POMMERY JEAN; POMMERY NICOLE; THURU XAVIER; QUESNEL BRUNO; GAUTRET PHILIPPE,期刊:Bioorganic & Medicinal Chemistry, 页码:6042-6054 , 文章类型: Article,,卷期:2011年19-20]
- Previous investigations on the incubation of phenstatin with rat and human microsomal fractions revealed the formation of nine main metabolites. The structures of eight of these metabolites have been now confirmed by syn...
- Metronidazole acid acyl sulfonamide: A novel class of anticancer agents and potential EGFR tyrosine kinase inhibitors
[作者:LUO YIN; LI YAO; QIU KEMING; LU XIANG; FU JIE; ZHU HAILIANG,期刊:Bioorganic & Medicinal Chemistry, 页码:6069-6076 , 文章类型: Article,,卷期:2011年19-20]
- A series of novel metronidazole derivatives were recently reported as potent anticancer agents targeting EGFR and HER-2 by our group [Qian, Y.; Zhang, H. J.; Zhang, H.; Xu, C.; Zhao, J.; Zhu, H. L Bioorg. Med. Chem. 2010...
|