- Tet family proteins and 5-hydroxymethylcytosine in development and disease
[作者:Tan, L; Shi, YG,期刊:Development, 页码:1895-1902 , 文章类型: Article,,卷期:2012年139-11]
- Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine, 5mC) has emerged as an important epigenetic modification that plays essential roles in development, aging and disease. However, ...
- Rp58 is essential for the growth and patterning of the cerebellum and for glutamatergic and GABAergic neuron development
[作者:Baubet, V; Xiang, CM; Molczan, A; Roccograndi, L; Melamed, S; Dahmane, N,期刊:Development, 页码:1903-1909 , 文章类型: Article,,卷期:2012年139-11]
- Cerebellum development depends on the correct differentiation of progenitors into neurons, a process controlled by a transcriptional program that remains poorly understood. Here we show that neural-specific deletion of t...
- Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis
[作者:Havis, E; Coumailleau, P; Bonnet, A; Bismuth, K; Bonnin, MA; Johnson, R; Fan, CM; Relaix, F; Shi, DL; Duprez, D,期刊:Development, 页码:1910-1920 , 文章类型: Article,,卷期:2012年139-11]
- The basic helix-loop-helix transcription factor MyoD is a central actor that triggers the skeletal myogenic program. Cell-autonomous and non-cell-autonomous regulatory pathways must tightly control MyoD expression to ens...
- Wnt5a and Wnt11 are essential for second heart field progenitor development
[作者:Cohen, ED; Miller, MF; Wang, ZC; Moon, RT; Morrisey, EE,期刊:Development, 页码:1931-1940 , 文章类型: Article,,卷期:2012年139-11]
- Wnt/beta-catenin has a biphasic effect on cardiogenesis, promoting the induction of cardiac progenitors but later inhibiting their differentiation. Second heart field progenitors and expression of the second heart field ...
- Response to the BMP gradient requires highly combinatorial inputs from multiple patterning systems in the Drosophila embryo
[作者:Liang, HL; Xu, M; Chuang, YC; Rushlow, C,期刊:Development, 页码:1956-1964 , 文章类型: Article,,卷期:2012年139-11]
- Pattern formation in the developing embryo relies on key regulatory molecules, many of which are distributed in concentration gradients. For example, a gradient of BMP specifies cell fates along the dorsoventral axis in ...
- The floral homeotic protein APETALA2 recognizes and acts through an AT-rich sequence element
[作者:Dinh, TT; Girke, T; Liu, XG; Yant, L; Schmid, M; Chen, XM,期刊:Development, 页码:1978-1986 , 文章类型: Article,,卷期:2012年139-11]
- Cell fate specification in development requires transcription factors for proper regulation of gene expression. In Arabidopsis, transcription factors encoded by four classes of homeotic genes, A, B, C and E, act in a com...
- Histone recognition and nuclear receptor co-activator functions of Drosophila Cara Mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3
[作者:Chauhan, C; Zraly, CB; Parilla, M; Diaz, MO; Dingwall, AK,期刊:Development, 页码:1997-2008 , 文章类型: Article,,卷期:2012年139-11]
- MLL2 and MLL3 histone lysine methyltransferases are conserved components of COMPASS-like co-activator complexes. In vertebrates, the paralogous MLL2 and MLL3 contain multiple domains required for epigenetic reading and w...
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