- The three R's of lung health and disease: repair, remodeling, and regeneration
[作者:Beers, MF; Morrisey, EE,期刊:Journal of clinical investigation, 页码:2065-2073 , 文章类型: Article,,卷期:2011年121-6]
- All tissues and organs can be classified according to their ability to repair and regenerate during adult homeostasis and after injury. Some exhibit a high rate of constant cell turnover, while others, such as the lung, ...
- Digging deeper into obesity
[作者:Ahima, RS,期刊:Journal of clinical investigation, 页码:2076-2079 , 文章类型: Review,,卷期:2011年121-6]
- The growing problem of obesity is associated with multiple morbidities, including increased risk of diabetes, hypertension, heart disease, sleep apnea, and cancer. Obesity promotes disability, decreases productivity, and...
- Sixteen years and counting: an update on leptin in energy balance
[作者:Gautron, L; Elmquist, JK,期刊:Journal of clinical investigation, 页码:2087-2093 , 文章类型: Review,,卷期:2011年121-6]
- Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and secreted by white adipose tissue. Since its discovery, leptin has been found to have profound effects on behavior, metabolic rate, end...
- Adipose tissue remodeling and obesity
[作者:Sun, K; Kusminski, CM; Scherer, PE,期刊:Journal of clinical investigation, 页码:2094-2101 , 文章类型: Review,,卷期:2011年121-6]
- To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, ...
- The role of lipid droplets in metabolic disease in rodents and humans
[作者:Greenberg, AS; Coleman, RA; Kraemer, FB; McManaman, JL; Obin, MS; Puri, V; Yan, QW; Miyoshi, H; Mashek, DG,期刊:Journal of clinical investigation, 页码:2102-2110 , 文章类型: Review,,卷期:2011年121-6]
- Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding ...
- Dynamics of insulin secretion and the clinical implications for obesity and diabetes
[作者:Seino, S; Shibasaki, T; Minami, K,期刊:Journal of clinical investigation, 页码:2118-2125 , 文章类型: Review,,卷期:2011年121-6]
- Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single beta cell, p...
- Circadian rhythms, sleep, and metabolism
[作者:Huang, WY; Ramsey, KM; Marcheva, B; Bass, J,期刊:Journal of clinical investigation, 页码:2133-2141 , 文章类型: Review,,卷期:2011年121-6]
- The discovery of the genetic basis for circadian rhythms has expanded our knowledge of the temporal organization of behavior and physiology. The observations that the circadian gene network is present in most living orga...
- The targeted podocyte
[作者:Fogo, AB,期刊:Journal of clinical investigation, 页码:2142-2145 , 文章类型: Editorial Material,,卷期:2011年121-6]
- The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of m...
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