- Osmotic Stress Resistance Imparts Acquired Anti-apoptotic Mechanisms in Lymphocytes
[作者:Bortner, CD; Scoltock, AB; Sifre, MI; Cidlowski, JA,期刊:Journal of Biological Chemistry, 页码:6284-6295 , 文章类型: Article,,卷期:2012年287-9]
- Apoptosis is a stochastic, physiological form of cell death that is characterized by unique morphological and biochemical properties. A defining feature of apoptosis in all cells is the apoptotic volume decrease or AVD, ...
- Cytochromes P450 CYP94C1 and CYP94B3 Catalyze Two Successive Oxidation Steps of Plant Hormone Jasmonoyl-isoleucine for Catabolic Turnover
[作者:Heitz, T; Widemann, E; Lugan, R; Miesch, L; Ullmann, P; Desaubry, L; Holder, E; Grausem, B; Kandel, S; Miesch, M; Werck-Reichhart, D; Pinot, F,期刊:Journal of Biological Chemistry, 页码:6296-6306 , 文章类型: Article,,卷期:2012年287-9]
- The jasmonate hormonal pathway regulates important defensive and developmental processes in plants. Jasmonoyl-isoleucine (JA-Ile) has been identified as a specific ligand binding the COI1-JAZ co-receptor to relieve repre...
- Amidoxime Reductase System Containing Cytochrome b(5) Type B (CYB5B) and MOSC2 Is of Importance for Lipid Synthesis in Adipocyte Mitochondria
[作者:Neve, EPA; Nordling, A; Andersson, TB; Hellman, U; Diczfalusy, U; Johansson, I; Ingelman-Sundberg, M,期刊:Journal of Biological Chemistry, 页码:6307-6317 , 文章类型: Article,,卷期:2012年287-9]
- Reduction of hydroxylamines and amidoximes is important for drug activation and detoxification of aromatic and heterocyclic amines. Such a reductase system was previously found to be of high activity in adipose tissue an...
- Identification of a Hypochlorite-specific Transcription Factor from Escherichia coli
[作者:Gebendorfer, KM; Drazic, A; Le, Y; Gundlach, J; Bepperling, A; Kastenmuller, A; Ganzinger, KA; Braun, N; Franzmann, TM; Winter, J,期刊:Journal of Biological Chemistry, 页码:6892-6903 , 文章类型: Article,,卷期:2012年287-9]
- Hypochlorite is a powerful oxidant produced by neutrophils to kill invading microorganisms. Despite this important physiological role of HOCl in fighting bacterial infections, no hypochlorite- specific stress response ha...
- In Channelrhodopsin-2 Glu-90 Is Crucial for Ion Selectivity and Is Deprotonated during the Photocycle
[作者:Eisenhauer, K; Kuhne, J; Ritter, E; Berndt, A; Wolf, S; Freier, E; Bartl, F; Hegemann, P; Gerwert, K,期刊:Journal of Biological Chemistry, 页码:6904-6911 , 文章类型: Article,,卷期:2012年287-9]
- The light-activated microbial ion channel channelrhodopsin-2 (ChR2) is a powerful tool to study cellular processes with high spatiotemporal resolution in the emerging field of optogenetics. To customize the channel prope...
- Tannic Acid Is a Natural beta-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice
[作者:Mori, T; Rezai-Zadeh, K; Koyama, N; Arendash, GW; Yamaguchi, H; Kakuda, N; Horikoshi-Sakuraba, Y; Tan, J; Town, T,期刊:Journal of Biological Chemistry, 页码:6912-6927 , 文章类型: Article,,卷期:2012年287-9]
- Amyloid precursor protein (APP) proteolysis is essential for production of amyloid-beta (A beta) peptides that form beta-amyloid plaques in brains of Alzheimer disease (AD) patients. Recent focus has been directed toward...
- G Protein-coupled Receptor Kinase 5 Is Localized to Centrosomes and Regulates Cell Cycle Progression
[作者:Michal, AM; So, CH; Beeharry, N; Shankar, H; Mashayekhi, R; Yen, TJ; Benovic, JL,期刊:Journal of Biological Chemistry, 页码:6928-6940 , 文章类型: Article,,卷期:2012年287-9]
- G protein-coupled receptor kinases (GRKs) are important regulators of G protein-coupled receptor function and mediate receptor desensitization, internalization, and signaling. While GRKs also interact with and/or phospho...
- Mechanism for Release of Alkaline Phosphatase Caused by Glycosylphosphatidylinositol Deficiency in Patients with Hyperphosphatasia Mental Retardation Syndrome
[作者:Murakami, Y; Kanzawa, N; Saito, K; Krawitz, PM; Mundlos, S; Robinson, PN; Karadimitris, A; Maeda, Y; Kinoshita, T,期刊:Journal of Biological Chemistry, 页码:6318-6325 , 文章类型: Article,,卷期:2012年287-9]
- Hyperphosphatasia mental retardation syndrome (HPMR), an autosomal recessive disease characterized by mental retardation and elevated serum alkaline phosphatase (ALP) levels, is caused by mutations in the coding region o...
- Interleukin 33 as a Mechanically Responsive Cytokine Secreted by Living Cells
[作者:Kakkar, R; Hei, H; Dobner, S; Lee, RT,期刊:Journal of Biological Chemistry, 页码:6941-6948 , 文章类型: Article,,卷期:2012年287-9]
- Interleukin 33 (IL-33), a member of the Interleukin 1 cytokine family, is implicated in numerous human inflammatory diseases such as asthma, atherosclerosis, and rheumatoid arthritis. Despite its pathophysiologic importa...
- Divergence of Pumilio/fem-3 mRNA Binding Factor (PUF) Protein Specificity through Variations in an RNA-binding Pocket
[作者:Qiu, C; Kershner, A; Wang, YM; Holley, CP; Wilinski, D; Keles, S; Kimble, J; Wickens, M; Hall, TMT,期刊:Journal of Biological Chemistry, 页码:6949-6957 , 文章类型: Article,,卷期:2012年287-9]
- mRNA control networks depend on recognition of specific RNA sequences. Pumilio-fem-3 mRNA binding factor (PUF) RNA-binding proteins achieve that specificity through variations on a conserved scaffold. Saccharomyces cerev...
- Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway (vol 286, pg 27882, 2011)
[作者:Guo, AJY; Choi, RCY; Cheung, AWH; Chen, VP; Xu, SL; Dong, TTX; Chen, JJ; Tsim, KWK,期刊:Journal of Biological Chemistry, 页码:6958-6958 , 文章类型: Correction,,卷期:2012年287-9]
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- Neurexin-1 alpha Contributes to Insulin-containing Secretory Granule Docking
[作者:Mosedale, M; Egodage, S; Calma, RC; Chi, NW; Chessler, SD,期刊:Journal of Biological Chemistry, 页码:6350-6361 , 文章类型: Article,,卷期:2012年287-9]
- Neurexins are a family of transmembrane, synaptic adhesion molecules. In neurons, neurexins bind to both sub-plasma membrane and synaptic vesicle-associated constituents of the secretory machinery, play a key role in the...
- Cell Contact-dependent Functional Selectivity of beta(2)-Adrenergic Receptor Ligands in Stimulating cAMP Accumulation and Extracellular Signal-regulated Kinase Phosphorylation
[作者:Kaya, AI; Onaran, HO; Ozcan, G; Ambrosio, C; Costa, T; Balli, S; Ugur, O,期刊:Journal of Biological Chemistry, 页码:6362-6374 , 文章类型: Article,,卷期:2012年287-9]
- Activation of beta(2)-adrenegic receptor (beta(2)-AR) leads to an increase in intracellular cAMP and activation of ERK. These two signals are activated by the interaction of the receptor with different transducer partner...
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