- The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation
[作者:Clement, CA; Kristensen, SG; Mollgard, K; Pazour, GJ; Yoder, BK; Larsen, LA; Christensen, ST,期刊:Journal of cell science, 页码:3070-3082 , 文章类型: Article,,卷期:2009年122-17]
- Defects in the assembly or function of primary cilia, which are sensory organelles, are tightly coupled to developmental defects and diseases in mammals. Here, we investigated the function of the primary cilium in regula...
- Developmental-stage-specific regulation of the polyubiquitin receptors in Drosophila melanogaster
[作者:Lipinszki, Z; Kiss, P; Pal, M; Deak, P; Szabo, A; Hunyadi-Gulyas, E; Klement, E; Medzihradszky, KF; Udvardy, A,期刊:Journal of cell science, 页码:3083-3092 , 文章类型: Article,,卷期:2009年122-17]
- Recognition of polyubiquitylated substrates by the proteasome is a highly regulated process that requires polyubiquitin receptors. We show here that the concentrations of the proteasomal and extraproteasomal polyubiquiti...
- BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54
[作者:Srivastava, V; Modi, P; Tripathi, V; Mudgal, R; De, S; Sengupta, S,期刊:Journal of cell science, 页码:3093-3103 , 文章类型: Article,,卷期:2009年122-17]
- Mutation of BLM helicase results in the autosomal recessive disorder Bloom syndrome (BS). Patients with BS exhibit hyper-recombination and are prone to almost all forms of cancer. BLM can exhibit its anti-recombinogenic ...
- MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2
[作者:Carter, EJ; Cosgrove, RA; Gonzalez, I; Eisemann, JH; Lovett, FA; Cobb, LJ; Pell, JM,期刊:Journal of cell science, 页码:3104-3112 , 文章类型: Article,,卷期:2009年122-17]
- During the differentiation of muscle satellite cells, committed myoblasts respond to specific signalling cues by exiting the cell cycle, migrating, aligning, expressing muscle-specific genes and finally fusing to form mu...
- Mechanism underlying activity-dependent insertion of TrkB into the neuronal surface
[作者:Zhao, L; Sheng, AL; Huang, SH; Yin, YX; Chen, B; Li, XZ; Zhang, Y; Chen, ZY,期刊:Journal of cell science, 页码:3123-3136 , 文章类型: Article,,卷期:2009年122-17]
- Activity-dependent insertion of tyrosine kinase receptor type 2 (TrkB receptor) into the plasma membrane can explain, in part, the preferential effect of brain-derived neurotrophic factor (BDNF) on active neurons; howeve...
- Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin
[作者:Coffey, GP; Rajapaksa, R; Liu, R; Sharpe, O; Kuo, CC; Krauss, SW; Sagi, Y; Davis, RE; Staudt, LM; Sharman, JP; Robinson, WH; Levy, S,期刊:Journal of cell science, 页码:3137-3144 , 文章类型: Article,,卷期:2009年122-17]
- CD81 is a tetraspanin family member involved in diverse cellular interactions in the immune and nervous systems and in cell fusion events. However, the mechanism of action of CD81 and of other tetraspanins has not been d...
- GAK, a regulator of clathrin-mediated membrane traffic, also controls centrosome integrity and chromosome congression
[作者:Shimizu, H; Nagamori, I; Yabuta, N; Nojima, H,期刊:Journal of cell science, 页码:3145-3152 , 文章类型: Article,,卷期:2009年122-17]
- Cyclin G-associated kinase (GAK) is an association partner of clathrin heavy chain (CHC) and is essential for clathrin-mediated membrane trafficking. Here, we report two novel functions of GAK: maintenance of proper cent...
- Functional consequences of cleavage, dissociation and exocytotic release of ZP3R, a C4BP-related protein, from the mouse sperm acrosomal matrix
[作者:Buffone, MG; Kim, KS; Doak, BJ; Rodriguez-Miranda, E; Gerton, GL,期刊:Journal of cell science, 页码:3153-3160 , 文章类型: Article,,卷期:2009年122-17]
- The acrosome is an exocytotic vesicle located on the apical tip of the sperm head. In addition to having different morphological regions, two biochemically distinct compartments can be defined within the acrosome: a part...
- An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix
[作者:Arnoult, D; Soares, F; Tattoli, I; Castanier, C; Philpott, DJ; Girardin, SE,期刊:Journal of cell science, 页码:3161-3168 , 文章类型: Article,,卷期:2009年122-17]
- NLRX1 is the only member of the Nod-like receptor (NLR) family that is targeted to the mitochondria, and its overexpression induces the generation of reactive oxygen species (ROS), thus impacting on NF kappa B- and JNK-d...
- In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction
[作者:Osakada, F; Jin, ZB; Hirami, Y; Ikeda, H; Danjyo, T; Watanabe, K; Sasai, Y; Takahashi, M,期刊:Journal of cell science, 页码:3169-3179 , 文章类型: Article,,卷期:2009年122-17]
- The use of stem-cell therapy to treat retinal degeneration holds great promise. However, definitive methods of retinal differentiation that do not depend on recombinant proteins produced in animal or Escherichia coli cel...
- RFX3 governs growth and beating efficiency of motile cilia in mouse and controls the expression of genes involved in human ciliopathies
[作者:El Zein, L; Ait-Lounis, A; Morle, L; Thomas, J; Chhin, B; Spassky, N; Reith, W; Durand, B,期刊:Journal of cell science, 页码:3180-3189 , 文章类型: Article,,卷期:2009年122-17]
- Cilia are cellular organelles that play essential physiological and developmental functions in various organisms. They can be classified into two categories, primary cilia and motile cilia, on the basis of their axonemal...
- Simian virus 40 large T antigen targets the microtubule-stabilizing protein TACC2
[作者:Tei, S; Saitoh, N; Funahara, T; Iida, S; Nakatsu, Y; Kinoshita, K; Kinoshita, Y; Saya, H; Nakao, M,期刊:Journal of cell science, 页码:3190-3198 , 文章类型: Article,,卷期:2009年122-17]
- The large T antigens of polyomaviruses target cellular proteins that control fundamental processes, including p53 and the RB family of tumor suppressors. Mechanisms that underlie T-antigen-induced cell transformation nee...
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