- Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector
[作者:Nirthanan, S; Garcia, G; Chiara, DC; Husain, SS; Cohen, JB,期刊:Journal of Biological Chemistry, 页码:22051-22062 , 文章类型: Article,,卷期:2008年283-32]
- Etomidate, one of the most potent general anesthetics used clinically, acts at micromolar concentrations as an anesthetic and positive allosteric modulator of gamma-aminobutyric acid responses, whereas it inhibits muscle...
- Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast
[作者:Udagawa, T; Nemoto, N; Wilkinson, CRM; Narashimhan, J; Jiang, L; Watt, S; Zook, A; Jones, N; Wek, RC; Bahler, J; Asano, K,期刊:Journal of Biological Chemistry, 页码:22063-22075 , 文章类型: Article,,卷期:2008年283-32]
- int-6 is one of the frequent integration sites for mouse mammary tumor viruses. Although its product is the e-subunit of translation initiation factor eIF3, other evidence indicates that it interacts with proteasomes or ...
- Interaction and functional interference of glucocorticoid receptor and SOCS1
[作者:Haffner, MC; Jurgeit, A; Berlato, C; Geley, S; Parajuli, N; Yoshimura, A; Doppler, W,期刊:Journal of Biological Chemistry, 页码:22089-22096 , 文章类型: Article,,卷期:2008年283-32]
- Cytokine and glucocorticoid (GC) hormone signaling act in an integrated fashion to control inflammation and immune response. Here we establish a new mode of interaction of these two pathways and propose Suppressor of Cyt...
- Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization
[作者:Fenske, SA; Yesilaltay, A; Pal, R; Daniels, K; Rigotti, A; Krieger, M; Kocher, O,期刊:Journal of Biological Chemistry, 页码:22097-22104 , 文章类型: Article,,卷期:2008年283-32]
- PDZK1 is a four-PDZ domain-containing scaffold protein that, via its first PDZ domain (PDZ1), binds to the C terminus of the high density lipoprotein (HDL) receptor scavenger receptor, class B, type I (SR-BI). Abolishing...
- Inhibition of apoptosome activation protects injured motor neurons from cell death
[作者:Kanungo, AK; Hao, ZY; Elia, AJ; Mak, TW; Henderson, JT,期刊:Journal of Biological Chemistry, 页码:22105-22112 , 文章类型: Article,,卷期:2008年283-32]
- Within the mammalian central nervous system many forms of neurodegenerative injury are regulated via programmed cell death, a highly conserved program of cellular suicide. Programmed cell death is regulated by multiple s...
- Structural and functional characterization of transmembrane segment IX of the NHE1 isoform of the Na+/H+ exchanger
[作者:Reddy, T; Ding, J; Li, XJ; Sykes, BD; Rainey, JK; Fliegel, L,期刊:Journal of Biological Chemistry, 页码:22018-22030 , 文章类型: Article,,卷期:2008年283-32]
- The Na+/H+ exchanger isoform 1 (NHE1) is an integral membrane protein that regulates intracellular pH by removing one intracellular H+ in exchange for one extracellular Na+. It has a large N-terminal membrane domain of 1...
- Structure-function analysis of the C3 binding region of Staphylococcus aureus immune subversion protein Sbi
[作者:Upadhyay, A; Burman, JD; Clark, EA; Leung, E; Isenman, DE; van den Elsen, JMH; Bagby, S,期刊:Journal of Biological Chemistry, 页码:22113-22120 , 文章类型: Article,,卷期:2008年283-32]
- Among the recently discovered Staphylococcus aureus immune evasion proteins, Sbi is unique in its ability to interact with components of both the adaptive and innate immune systems of the host. Sbi domains I and II (Sbi-...
- The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase - An essential enzyme in the gamma-glutamyl cycle
[作者:Oakley, AJ; Yamada, T; Liu, D; Coggan, M; Clark, AG; Board, PG,期刊:Journal of Biological Chemistry, 页码:22031-22042 , 文章类型: Article,,卷期:2008年283-32]
- The hypothetical protein C7orf24 has been implicated as a cancer marker with a potential role in cell proliferation. We have identified C7orf24 as gamma-glutamyl cyclotransferase (GGCT) that catalyzes the formation of 5-...
- Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle - II. Heterogeneity of metabolite labeling pattern
[作者:Yang, LL; Kasumov, T; Kombu, RS; Zhu, SH; Cendrowski, AV; David, F; Anderson, VE; Kelleher, JK; Brunengraber, H,期刊:Journal of Biological Chemistry, 页码:21988-21996 , 文章类型: Article,,卷期:2008年283-32]
In this second of two companion articles, we compare the mass isotopomer distribution of metabolites of liver gluconeogenesis and citric acid cycle labeled from (NaHCO3)-C-13 or dimethyl [1,4-C-13(2)] succinate. The m...
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