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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共26条记录   Reprogramming of pancreatic exocrine cells towards a beta (beta) cell character using Pdx1, Ngn3 and MafA [作者：Akinci, E; Banga, A; Greder, LV; Dutton, JR; Slack, JMW,期刊：Biochemical Journal, 页码：539-550 , 文章类型： Article，,卷期：2012年442-3] Pdx1 (pancreatic and duodenal homeobox 1), Ngn3 (neurogenin 3) and MafA (v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A) have been reported to bring about the transdifferentiation of pancreatic exocrine... A Golgi-localized MATE transporter mediates iron homoeostasis under osmotic stress in Arabidopsis [作者：Seo, PJ; Park, J; Park, MJ; Kim, YS; Kim, SG; Jung, JH; Park, CM,期刊：Biochemical Journal, 页码：551-561 , 文章类型： Article，,卷期：2012年442-3] Iron is an essential micronutrient that acts as a cofactor in a wide variety of pivotal metabolic processes, such as the electron transport chain of respiration, photosynthesis and redox reactions, in plants. However, it... A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin [作者：Tseng, TS; Cheng, CS; Chen, DJ; Shih, MF; Liu, YN; Hsu, STD; Lyu, PC,期刊：Biochemical Journal, 页码：563-572 , 文章类型： Article，,卷期：2012年442-3] Drosophila melanogaster crammer is a novel cathepsin inhibitor that is involved in LTM (long-term memory) formation. The mechanism by which the inhibitory activity is regulated remains unclear. In the present paper we ha... RCD1-DREB2A interaction in leaf senescence and stress responses in Arabidopsis thaliana [作者：Vainonen, JP; Jaspers, P; Wrzaczek, M; Lamminmaki, A; Reddy, RA; Vaahtera, L; Brosche, M; Kangasjarvi, J,期刊：Biochemical Journal, 页码：573-581 , 文章类型： Article，,卷期：2012年442-3] Transcriptional regulation of gene expression is one major determinant of developmental control and stress adaptation in virtually all living organisms. In recent years numerous transcription factors controlling various ... Plastoquinone-9 biosynthesis in cyanobacteria differs from that in plants and involves a novel 4-hydroxybenzoate solanesyltransferase [作者：Sadre, R; Pfaff, C; Buchkremer, S,期刊：Biochemical Journal, 页码：621-629 , 文章类型： Article，,卷期：2012年442-3] PQ-9 (plastoquinone-9) has a central role in energy transformation processes in cyanobacteria by mediating electron transfer in both the photosynthetic as well as the respiratory electron transport chain. The present stu... Functional analysis of membranous F-0-a subunit of F1F0-ATP synthase by in vitro protein synthesis [作者：Kuruma, Y; Suzuki, T; Ono, S; Yoshida, M; Ueda, T,期刊：Biochemical Journal, 页码：631-638 , 文章类型： Article，,卷期：2012年442-3] The a subunit of F1F0 (F1F0-ATP synthase) is a highly hydrophobic protein with five putative transmembrane helices which plays a central role in H+-translocation coupled with ATP synthesis/hydrolysis. In the present pape... Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response [作者：McKibbin, C; Mares, A; Piacenti, M; Williams, H; Roboti, P; Puumalainen, M; Callan, AC; Lesiak-Mieczkowska, K; Linder, S; Harant, H; High, S; Flitsch, SL; Whitehead, RC; Swanton, E,期刊：Biochemical Journal, 页码：639-648 , 文章类型： Article，,卷期：2012年442-3] Selective small-molecule inhibitors represent powerful tools for the dissection of complex biological processes. ES1 (eeyarestatin 1) is a novel modulator of ER (endoplasmic reticulum) function. In the present study, we ... Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells [作者：Navarro, MN; Sinclair, LV; Feijoo-Carnero, C; Clarke, R; Matthews, SA; Cantrell, DA,期刊：Biochemical Journal, 页码：649-659 , 文章类型： Article，,卷期：2012年442-3] PKD (protein kinase D) 2 is a serine/threonine kinase activated by diacylglycerol in response to engagement of antigen receptors in lymphocytes. To explore PKD2 regulation and function in TCR (T-cell antigen receptor) si... Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes [作者：Wu, Y; Steinbergs, N; Murray-Stewart, T; Marton, LJ; Casero, RA,期刊：Biochemical Journal, 页码：693-701 , 文章类型： Article，,卷期：2012年442-3] Epigenetic gene silencing is an important mechanism in the initiation and progression of cancer. Abnormal DNA CpG island hypermethylation and histone modifications are involved in aberrant silencing of tumour-suppressor ... Folded functional lipid-poor apolipoprotein A-I obtained by heating of high-density lipoproteins: relevance to high-density lipoprotein biogenesis [作者：Jayaraman, S; Cavigiolio, G; Gursky, O,期刊：Biochemical Journal, 页码：703-712 , 文章类型： Article，,卷期：2012年442-3] HDL (high-density lipoproteins) remove cell cholesterol and protect from atherosclerosis. The major HDL protein is apoA-I (apolipoprotein A-I). Most plasma apoA-I circulates in lipoproteins, yet similar to 5% forms monom... Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease [作者：Bhatia, S; Knoch, B; Wong, J; Kim, WS; Else, PL; Oakley, AJ; Garner, B,期刊：Biochemical Journal, 页码：713-721 , 文章类型： Article，,卷期：2012年442-3] ApoD (apolipoprotein D) is up-regulated in AD (Alzheimer's disease) and upon oxidative stress. ApoD inhibits brain lipid peroxidation in vivo, but the mechanism is unknown. Specific methionine residues may inhibit lipid ... Cell signalling by reactive lipid species: new concepts and molecular mechanisms [作者：Higdon, A; Diers, AR; Oh, JY; Landar, A; Darley-Usmar, VM,期刊：Biochemical Journal, 页码：453-464 , 文章类型： Review，,卷期：2012年442-3] The process of lipid peroxidation is widespread in biology and is mediated through both enzymatic and non-enzymatic pathways. A significant proportion of the oxidized lipid products are electrophilic in nature, the RLS (... PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances [作者：So, L; Fruman, DA,期刊：Biochemical Journal, 页码：465-481 , 文章类型： Review，,卷期：2012年442-3] Activation of PI3K (phosphoinositide 3-kinase) is a shared response to engagement of diverse types of transmembrane receptors. Depending on the cell type and stimulus, PI3K activation can promote different fates includin... Allosteric antibody inhibition of human hepsin protease [作者：Koschubs, T; Dengl, S; Durr, H; Kaluza, K; Georges, G; Hartl, C; Jennewein, S; Lanzendorfer, M; Auer, J; Stern, A; Huang, KS; Packman, K; Gubler, U; Kostrewa, D; Ries, S; Hansen, S; Kohnert, U; Cramer, P; Mundigl, O,期刊：Biochemical Journal, 页码：483-494 , 文章类型： Article，,卷期：2012年442-3] Hepsin is a type II transmembrane senile protease that is expressed in several human tissues. Overexpression of hepsin has been found to correlate with tumour progression and metastasis, which is so far best studied for ... The chromatin-binding protein HMGN3 stimulates histone acetylation and transcription across the Glyt1 gene [作者：Barkess, G; Postnikov, Y; Campos, CD; Mishra, S; Mohan, G; Verma, S; Bustin, M; West, KL,期刊：Biochemical Journal, 页码：495-505 , 文章类型： Article，,卷期：2012年442-3] HMGNs are nucleosome-binding proteins that alter the pattern of histone modifications and modulate the binding of linker histones to chromatin. The HMGN3 family member exists as two splice forms. HMGN3a which is full-len... Macromolecular and small-molecule modulation of intracellular A beta(42) aggregation and associated toxicity [作者：Chakrabortee, S; Liu, Y; Zhang, L; Matthews, HR; Zhang, HR; Pan, N; Cheng, CR; Guan, SH; Guo, DA; Huang, ZB; Zheng, YZ; Tunnacliffe, A,期刊：Biochemical Journal, 页码：507-515 , 文章类型： Article，,卷期：2012年442-3] A beta (amyloid beta-peptide) has a central role in AD (Alzheimer's disease) where neuronal toxicity is linked to its extracellular and intracellular accumulation as oligomeric species. Searching for molecules that atten...