个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains [作者：Pigott, CR; Mikolajek, H; Moore, CE; Finn, SJ; Phippen, CW; Werner, JM; Proud, CG,期刊：Biochemical Journal, 页码：105-118 , 文章类型： Article，,卷期：2012年442-1] eEF2K (eukaryotic elongation factor 2 kinase) is a Ca2+/CaM (calmodulin)-dependent protein kinase which regulates the translation elongation machinery. eEF2K belongs to the small group of so-called 'alpha-kinases' which ... Escl: a crucial component of the type III secretion system forms the inner rod structure in enteropathogenic Escherichia coli [作者：Sal-Man, N; Deng, WY; Finlay, BB,期刊：Biochemical Journal, 页码：119-125 , 文章类型： Article，,卷期：2012年442-1] The T3SS (type III secretion system) is a multi-protein complex that plays a central role in the virulence of many Gram-negative bacterial pathogens. This apparatus spans both bacterial membranes and transports virulence... Induction of group IVC phospholipase A(2) in allergic asthma: transcriptional regulation by TNF alpha in bronchoepithelial cells [作者：Bickford, JS; Newsom, KJ; Herlihy, JD; Mueller, C; Keeler, B; Qiu, XL; Walters, JN; Su, N; Wallet, SM; Flotte, TR; Nick, HS,期刊：Biochemical Journal, 页码：127-137 , 文章类型： Article，,卷期：2012年442-1] Airway inflammation in allergen-induced asthma is associated with eicosanoid release. These bioactive lipids exhibit anti-and pro-inflammatory activities with relevance to pulmonary pathophysiology. We hypothesized that ... Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration [作者：Schaefer, A; Nethe, M; Hordijk, PL,期刊：Biochemical Journal, 页码：13-25 , 文章类型： Review，,卷期：2012年442-1] Post-translational modifications are used by cells to link additional information to proteins. Most modifications are subtle and concern small moieties such as a phosphate group or a lipid. In contrast, protein ubiquityl... CaMKII-gamma mediates phosphorylation of BAD at Ser(170) to regulate cytokine-dependent survival and proliferation [作者：Hojabrpour, P; Waissbluth, I; Ghaffari, M; Cox, ME; Duronio, V,期刊：Biochemical Journal, 页码：139-149 , 文章类型： Article，,卷期：2012年442-1] Phosphorylation of the BH3 (Bcl-2 homology domain 3)-only protein BAD (Bcl-2/Bcl-X-L-antagonist, causing cell death) can either directly disrupt its association with the pro-survival proteins Bcl-X-L and/or Bcl-2, or cau... Both p110 alpha and p110 beta isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor [作者：Berenjeno, IM; Guillermet-Guibert, J; Pearce, W; Gray, A; Fleming, S; Vanhaesebroeck, B,期刊：Biochemical Journal, 页码：151-159 , 文章类型： Article，,卷期：2012年442-1] The PI3K (phosphoinositide 3-kinase) pathway is commonly activated in cancer as a consequence of inactivation of the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10), a major negative re... Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo [作者：Smith, GC; Ong, WK; Rewcastle, GW; Kendall, JD; Han, WP; Shepherd, PR,期刊：Biochemical Journal, 页码：161-169 , 文章类型： Article，,卷期：2012年442-1] In in vitro studies class-I PI3Ks (phosphoinositide 3-kinases), class-II PI3Ks and mTOR (mammalian target of rapamycin) have all been described as having roles in the regulation of glucose metabolism. The relative role e... Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1 [作者：Kumano-Kuramochi, M; Shimozu, Y; Wakita, C; Ohnishi-Kameyama, M; Shibata, T; Matsunaga, S; Takano-Ishikawa, Y; Watanabe, J; Goto, M; Xie, Q; Komba, S; Uchida, K; Machida, S,期刊：Biochemical Journal, 页码：171-180 , 文章类型： Article，,卷期：2012年442-1] LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) is an endothelial scavenger receptor that is important for the uptake of OxLDL (oxidized low-density lipoprotein) and contributes to the pathogenesis of ath... A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster [作者：Saisawang, C; Wongsantichon, J; Ketterman, AJ,期刊：Biochemical Journal, 页码：181-190 , 文章类型： Article，,卷期：2012年442-1] The cytosolic GST (glutathione transferase) superfamily has been annotated in the Drosophila melanogaster genome database. Of 36 genes, four undergo alternative splicing to yield a total of 41 GST proteins. In the presen... Cytochrome c-mediated formation of S-nitrosothiol in cells [作者：Broniowska, KA; Keszler, A; Basu, S; Kim-Shapiro, DB; Hogg, N,期刊：Biochemical Journal, 页码：191-197 , 文章类型： Article，,卷期：2012年442-1] S-nitrosothiols are products of nitric oxide (NO) metabolism that have been implicated in a plethora of signalling processes. However, mechanisms of S-nitrosothiol formation in biological systems are uncertain, and no ef... Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells [作者：Origanti, S; Nowotarski, SL; Carr, TD; Sass-Kuhn, S; Xiao, L; Wang, JY; Shantz, LM,期刊：Biochemical Journal, 页码：199-207 , 文章类型： Article，,卷期：2012年442-1] Upon Ras activation, ODC (ornithine decarboxylase) is markedly induced, and numerous studies suggest that ODC expression is controlled by Ras effector pathways. ODC is therefore a potential target in the treatment and pr... Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35 [作者：Harbour, ME; Breusegem, SY; Seaman, MNJ,期刊：Biochemical Journal, 页码：209-220 , 文章类型： Article，,卷期：2012年442-1] The retromer complex is a conserved endosomal protein sorting complex that sorts membrane proteins into nascent endosomal tubules. The recognition of membrane proteins is mediated by the cargo-selective retromer complex,... Ellagic acid, a new antiglycating agent: its inhibition of N-epsilon-(carboxymethyl)lysine [作者：Muthenna, P; Akileshwari, C; Reddy, GB,期刊：Biochemical Journal, 页码：221-230 , 文章类型： Article，,卷期：2012年442-1] Non-enzymatic glycation is a complex series of reactions between reducing sugars and amino groups of proteins. Accumulation of AGEs (advanced glycation end-products) due to non-enzymatic glycation has been related to sev... Abnormal actin binding of aberrant beta-tropomyosins is a molecular cause of muscle weakness in TPM2-related nemaline and cap myopathy [作者：Marttila, M; Lemola, E; Wallefeld, W; Memo, M; Donner, K; Laing, NG; Marston, S; Gronholm, M; Wallgren-Pettersson, C,期刊：Biochemical Journal, 页码：231-239 , 文章类型： Article，,卷期：2012年442-1] NM (nemaline myopathy) is a rare genetic muscle disorder defined on the basis of muscle weakness and the presence of structural abnormalities in the muscle fibres, i.e. nemaline bodies. The related disorder cap myopathy ... New insights into the structure of the reaction centre from Blastochloris viridis: evolution in the laboratory [作者：Roszak, AW; Moulisova, V; Reksodipuro, ADP; Gardiner, AT; Fujii, R; Hashimoto, H; Isaacs, NW; Cogdell, RJ,期刊：Biochemical Journal, 页码：27-37 , 文章类型： Article，,卷期：2012年442-1] Newly determined crystal structures of the photosynthetic RC (reaction centre) from two substrains of the non-sulfur purple bacterium Blastochloris viridis strain DSM 133, together with analysis of their gene sequences, ... Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington's disease [作者：Rush, DB; Leon, RT; McCollum, MH; Treu, RW; Wei, JN,期刊：Biochemical Journal, 页码：39-48 , 文章类型： Article，,卷期：2012年442-1] HD (Huntington's disease) is caused by an expanded polyQ (polyglutamine) repeat in the htt (huntingtin protein). GABAergic medium spiny neurons in the striatum are mostly affected in HD. However, mhtt (mutant huntingtin)...