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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Inactivation of ceramide transfer protein during pro-apoptotic stress by Golgi disassembly and caspase cleavage [作者：Chandran, S; Machamer, CE,期刊：Biochemical Journal, 页码：391-401 , 文章类型： Article，,卷期：2012年442-2] The mammalian Golgi apparatus is composed of multiple stacks of cisternal membranes organized laterally into a polarized ribbon. Furthermore, trans-Golgi membranes come in close apposition with ER (endoplasmic reticulum)... Inhibition of glutaminyl cyclase attenuates cell migration modulated by monocyte chemoattractant proteins [作者：Chen, YL; Huang, KF; Kuo, WC; Lo, YC; Lee, YM; Wang, AHJ,期刊：Biochemical Journal, 页码：403-412 , 文章类型： Article，,卷期：2012年442-2] QC (glutaminyl cyclase) catalyses the formation of N-terminal pGlu (pyroglutamate) in peptides and proteins. pGlu formation in chemoattractants may participate in the regulation of macrophage activation and migration. Ho... MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid beta precursor protein and presenilins [作者：Tachi, N; Hashimoto, Y; Matsuoka, M,期刊：Biochemical Journal, 页码：413-422 , 文章类型： Article，,卷期：2012年442-2] The death of cholinergic neurons in the cerebral cortex and certain subcortical regions is linked to irreversible dementia relevant to AD (Alzheimer's disease). Although multiple studies have shown that expression of a F... Oxidation of Met(1606) in von Willebrand factor is a risk factor for thrombotic and septic complications in chronic renal failure [作者：De Filippis, V; Lancellotti, S; Maset, F; Spolaore, B; Pozzi, N; Gambaro, G; Oggianu, L; Calo, LA; De Cristofaro, R,期刊：Biochemical Journal, 页码：423-432 , 文章类型： Article，,卷期：2012年442-2] CKD (chronic kidney disease) is a life-threatening pathology, often requiring HD (haemodialysis) and characterized by high OS (oxidative stress), inflammation and perturbation of vascular endothelium. HD patients have in... Secreted CXCL12 (SDF-1) forms dimers under physiological conditions [作者：Ray, P; Lewin, SA; Mihalko, LA; Lesher-Perez, SC; Takayama, S; Luker, KE; Luker, GD,期刊：Biochemical Journal, 页码：433-442 , 文章类型： Article，,卷期：2012年442-2] Chemokine CXCL12 (CXC chemokine ligand 12) signalling through CXCR (CXC chemokine receptor) 4 and CXCR7 has essential functions in development and underlies diseases including cancer, atherosclerosis and autoimmunity. Ch... Interfacial water molecules in SH3 interactions: a revised paradigm for polyproline recognition [作者：Martin-Garcia, JM; Ruiz-Sanz, J; Luque, I,期刊：Biochemical Journal, 页码：443-451 , 文章类型： Article，,卷期：2012年442-2] In spite of its biomedical relevance, polyproline recognition is still not fully understood. The disagreement between the current description of SH3 (Src homology 3) complexes and their thermodynamic behaviour calls for ... Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence [作者：Panneerselvam, P; Singh, LP; Ho, B; Chen, JZ; Ding, JL,期刊：Biochemical Journal, 页码：263-271 , 文章类型： Article，,卷期：2012年442-2] The fifth and the most well-conserved member of the TLR (Toll-like receptor) adaptor, SARM (sterile alpha- and HEAT/armadillo-motif-containing protein), has been reported to be an important mediator of apoptosis. However... Epidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells [作者：Liu, ZW; Yan, RL; Al-Salman, A; Shen, Y; Bu, YW; Ma, J; Luo, DX; Huang, CF; Jiang, YY; Wilber, A; Mo, YY; Huang, MC; Zhao, YP; Cao, DL,期刊：Biochemical Journal, 页码：273-282 , 文章类型： Article，,卷期：2012年442-2] AKR1B10 (aldo-keto reductase 1B10) is overexpressed in liver and lung cancer, and plays a critical role in tumour development and progression through promoting lipogenesis and eliminating cytotoxic carbonyls. AKR1B10 is ... The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity [作者：Yu, Q; Zheng, XF,期刊：Biochemical Journal, 页码：283-291 , 文章类型： Article，,卷期：2012年442-2] UGPase (UDP-glucose pyrophosphorylase) is highly conserved among eukaryotes. UGPase reversibly catalyses the formation of UDP-glucose and is critical in carbohydrate metabolism. Previous studies have mainly focused on th... An aspartate residue in the external vestibule of GLYT2 (glycine transporter 2) controls cation access and transport coupling [作者：Perez-Siles, G; Nunez, E; Morreale, A; Jimenez, E; Leo-Macias, A; Pita, G; Cherubino, F; Sangaletti, R; Bossi, E; Ortiz, AR; Aragon, C; Lopez-Corcuera, B,期刊：Biochemical Journal, 页码：323-334 , 文章类型： Article，,卷期：2012年442-2] Synaptic glycine levels are controlled by GLYTs (glycine transporters). GLYT1 is the main regulator of synaptic glycine concentrations and catalyses Na+-Cl--glycine co-transport with a 2:1:1 stoichiometry. In contrast, n... Lactococcus lactis HemW (HemN) is a haem-binding protein with a putative role in haem trafficking [作者：Abicht, HK; Martinez, J; Layer, G; Jahn, D; Solioz, M,期刊：Biochemical Journal, 页码：335-343 , 文章类型： Article，,卷期：2012年442-2] Lactococcus lactis cannot synthesize haem, but when supplied with haem, expresses a cytochrome bd oxidase. Apart from the cydAB structural genes for this oxidase, L. lactis features two additional genes, hemH and hemW (h... Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells [作者：Novellasdemunt, L; Obach, M; Millan-Arino, L; Manzano, A; Ventura, F; Rosa, JL; Jordan, A; Navarro-Sabate, A; Bartrons, R,期刊：Biochemical Journal, 页码：345-356 , 文章类型： Article，,卷期：2012年442-2] PFKFB (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P-2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is exten... Plant cell walls to ethanol [作者：Jordan, DB; Bowman, MJ; Braker, JD; Dien, BS; Hector, RE; Lee, CC; Mertens, JA; Wagschal, K,期刊：Biochemical Journal, 页码：241-252 , 文章类型： Review，,卷期：2012年442-2] Conversion of plant cell walls to ethanol constitutes second generation bioethanol production. The process consists of several steps: biomass selection/genetic modification, physiochemical pretreatment, enzymatic sacchar... Role and function of macrophages in the metabolic syndrome [作者：Bhargava, P; Lee, CH,期刊：Biochemical Journal, 页码：253-262 , 文章类型： Review，,卷期：2012年442-2] Macrophages are key innate immune effector cells best known for their role as professional phagocytes, which also include neutrophils and dendritic cells. Recent evidence indicates that Macrophages are also key players i... Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways [作者：Chang, MC; Chen, CA; Chen, PJ; Chiang, YC; Chen, YL; Mao, TL; Lin, HW; Chiang, WHL; Cheng, WF,期刊：Biochemical Journal, 页码：293-302 , 文章类型： Article，,卷期：2012年442-2] Ovarian cancer has one of the highest mortalities in malignancies in women, but little is known of its tumour progression properties and there is still no effective molecule that can monitor its growth or therapeutic res... ALAS1 gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FOXO1 by vanadate in diabetic mice [作者：Oliveri, LM; Davio, C; Batlle, AMD; Gerez, EN,期刊：Biochemical Journal, 页码：303-310 , 文章类型： Article，,卷期：2012年442-2] Porphyrias are diseases caused by partial deficiencies of haem biosynthesis enzymes. Acute porphyrias are characterized by a neuropsychiatric syndrome with intermittent induction of hepatic ALAS1 (delta-aminolaevulinate ...